Omeprazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.219878
LMO7 LIM domain 7 0.186524
TIMP3 TIMP metallopeptidase inhibitor 3 0.18197
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.144447
DPYD dihydropyrimidine dehydrogenase 0.124489
ITGA6 integrin, alpha 6 0.120259
FLNB filamin B, beta 0.114524
PDLIM5 PDZ and LIM domain 5 0.106159
PALM2AKAP2 PALM2 and AKAP2 fusion 0.101091
RASAL2 RAS protein activator like 2 0.0876198
MSN moesin 0.0871464
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0865441
PDE4D phosphodiesterase 4D, cAMP-specific 0.0837539
SLC35F3 solute carrier family 35, member F3 0.0791079
ALCAM activated leukocyte cell adhesion molecule 0.0766895
CD44 CD44 molecule (Indian blood group) 0.0728657
LDHA lactate dehydrogenase A 0.0724052
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0697833
PLS3 plastin 3 0.0684027
MACF1 microtubule-actin crosslinking factor 1 0.0678791
MYOF myoferlin 0.0676289
DOCK5 dedicator of cytokinesis 5 0.0669849
APLP2 amyloid beta (A4) precursor-like protein 2 0.0618665
RABGAP1L RAB GTPase activating protein 1-like 0.0590325
SULF1 sulfatase 1 0.0590263
CDK6 cyclin-dependent kinase 6 0.0585352
PICALM phosphatidylinositol binding clathrin assembly protein 0.0570181
JMJD1C jumonji domain containing 1C 0.0562055
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0560456
TSC22D1 TSC22 domain family, member 1 0.0551452
MYO10 myosin X 0.0550206
EXT1 exostosin glycosyltransferase 1 0.0543004
SAMD9 sterile alpha motif domain containing 9 0.0542368
ANO1 anoctamin 1, calcium activated chloride channel 0.0538495
AKAP13 A kinase (PRKA) anchor protein 13 0.0534092
EMP1 epithelial membrane protein 1 0.0533367
ENO1 enolase 1, (alpha) 0.0526279
MYH9 myosin, heavy chain 9, non-muscle 0.0513168
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0512807
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0503811
MBNL1 muscleblind-like splicing regulator 1 0.0498175
PSD3 pleckstrin and Sec7 domain containing 3 0.0494209
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0492653
NDRG1 N-myc downstream regulated 1 0.047763
PODXL podocalyxin-like 0.0477247
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0477212
ASPH aspartate beta-hydroxylase 0.0476357
MTSS1 metastasis suppressor 1 0.0475492
RCOR1 REST corepressor 1 0.0475045
ZSWIM6 zinc finger, SWIM-type containing 6 0.0473146
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0469246
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0463877
FOXO1 forkhead box O1 0.0463302
PALLD palladin, cytoskeletal associated protein 0.0458363
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0457768
DST dystonin 0.044698
AMOTL1 angiomotin like 1 0.0446589
VCL vinculin 0.0443799
EZR ezrin 0.044012
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0438307
ZEB1 zinc finger E-box binding homeobox 1 0.0433228
INTS6 integrator complex subunit 6 0.0415625
UTRN utrophin 0.040888
FN1 fibronectin 1 0.0408328
MECOM MDS1 and EVI1 complex locus 0.0406258
ANXA1 annexin A1 0.0406199
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0402899
TGM2 transglutaminase 2 0.0401031
EGFR epidermal growth factor receptor 0.0400616
RAI14 retinoic acid induced 14 0.0395518
IQGAP1 IQ motif containing GTPase activating protein 1 0.0394109
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0386209
LAMC2 laminin, gamma 2 0.0380131
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0378625
GRB10 growth factor receptor-bound protein 10 0.0373826
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0372966
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.037184
TRIO trio Rho guanine nucleotide exchange factor 0.0367578
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0364986
ESYT2 extended synaptotagmin-like protein 2 0.0361432
RNF217 ring finger protein 217 0.0359587
MCL1 myeloid cell leukemia 1 0.0359262
MPRIP myosin phosphatase Rho interacting protein 0.0358327
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0357767
SULF2 sulfatase 2 0.0357661
EFNA5 ephrin-A5 0.0355507
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0354111
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0353186
DGKH diacylglycerol kinase, eta 0.0347893
CALB1 calbindin 1, 28kDa 0.0347317
F3 coagulation factor III (thromboplastin, tissue factor) 0.0346279
TPM3 tropomyosin 3 0.0345908
HMGA2 high mobility group AT-hook 2 0.0345397
ITPRID2 ITPR interacting domain containing 2 0.0341616
FAM107B family with sequence similarity 107, member B 0.0339867
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0337398
RIGI RNA sensor RIG-I 0.0337107
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0337095
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033607
POTEF POTE ankyrin domain family, member F 0.0334202

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0867875
TPT1 tumor protein, translationally-controlled 1 -0.0599589
KIAA1217 KIAA1217 -0.053107
MT2A metallothionein 2A -0.0471966
RPLP2 ribosomal protein, large, P2 -0.044527
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0445149
GNAS GNAS complex locus -0.0417636
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0411372
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0409318
RPS21 ribosomal protein S21 -0.0368065
RPS3 ribosomal protein S3 -0.036491
PTMA prothymosin, alpha -0.0358706
RPS19 ribosomal protein S19 -0.0347406
OGA O-GlcNAcase -0.0345517
NAMPT nicotinamide phosphoribosyltransferase -0.0321215
RPLP1 ribosomal protein, large, P1 -0.031192
RPS24 ribosomal protein S24 -0.0311669
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0290064
S100A2 S100 calcium binding protein A2 -0.0287988
RPL11 ribosomal protein L11 -0.0278223
RPL37A ribosomal protein L37a -0.027751
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0274285
LMNA lamin A/C -0.0269462
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0260592
ANKRD10 ankyrin repeat domain 10 -0.0260192
KDM3A lysine (K)-specific demethylase 3A -0.0259799
PNISR PNN-interacting serine/arginine-rich protein -0.0258828
RPS8 ribosomal protein S8 -0.0254503
RPL12 ribosomal protein L12 -0.0250356
H1-0 H1.0 linker histone -0.0248143
RPS6 ribosomal protein S6 -0.0244397
RPL19 ribosomal protein L19 -0.0244073
FSCN1 fascin actin-bundling protein 1 -0.0241506
ATP5F1E ATP synthase F1 subunit epsilon -0.0240689
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0240534
RPS12 ribosomal protein S12 -0.0239348
RPL23 ribosomal protein L23 -0.0237301
RPL30 ribosomal protein L30 -0.0236017
RPL34 ribosomal protein L34 -0.0231925
HLA-B major histocompatibility complex, class I, B -0.0227311
RPL35A ribosomal protein L35a -0.0219981
S100A4 S100 calcium binding protein A4 -0.0216731
IER3 immediate early response 3 -0.0216483
RPL26 ribosomal protein L26 -0.0215778
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0215372
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0212419
RPS27 ribosomal protein S27 -0.0209201
GARS1 glycyl-tRNA synthetase 1 -0.0208627
S100A6 S100 calcium binding protein A6 -0.0206122
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0205805
RPL37 ribosomal protein L37 -0.0205704
SLC38A1 solute carrier family 38, member 1 -0.020379
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0201875
IFITM3 interferon induced transmembrane protein 3 -0.0196885
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0196481
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0194471
WSB1 WD repeat and SOCS box containing 1 -0.0193091
DLG1 discs, large homolog 1 (Drosophila) -0.0191744
RPS29 ribosomal protein S29 -0.0191634
RPL36 ribosomal protein L36 -0.0190074
PRELID2 PRELI domain containing 2 -0.018998
SQLE squalene epoxidase -0.0189507
CAVIN1 caveolae associated protein 1 -0.0188722
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0185894
RPL35 ribosomal protein L35 -0.0184976
EIF1 eukaryotic translation initiation factor 1 -0.0183815
RPS27A ribosomal protein S27a -0.0182013
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0175286
RLF rearranged L-myc fusion -0.0173185
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0172552
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0171672
MATR3 matrin 3 -0.017056
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.016833
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0167396
BHLHE40 basic helix-loop-helix family, member e40 -0.0167327
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0163576
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0163222
HMGB1 high mobility group box 1 -0.0162897
RPL13A ribosomal protein L13a -0.0161475
LIFR leukemia inhibitory factor receptor alpha -0.0160081
RBM39 RNA binding motif protein 39 -0.015762
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0155189
RB1CC1 RB1-inducible coiled-coil 1 -0.0153839
RPL31 ribosomal protein L31 -0.0153711
RPS20 ribosomal protein S20 -0.0150863
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0150828
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0147708
ZFR zinc finger RNA binding protein -0.0146492
PDGFB platelet-derived growth factor beta polypeptide -0.0145413
RPL18 ribosomal protein L18 -0.0144906
RPS16 ribosomal protein S16 -0.0144297
NDFIP1 Nedd4 family interacting protein 1 -0.0142549
HIP1 huntingtin interacting protein 1 -0.0141467
MT1X metallothionein 1X -0.014131
CEMIP cell migration inducing protein, hyaluronan binding -0.0140665
BZW2 basic leucine zipper and W2 domains 2 -0.0140066
SMAD3 SMAD family member 3 -0.0139269
RPS25 ribosomal protein S25 -0.0139096
GM2A GM2 ganglioside activator -0.0138813
CNRIP1 cannabinoid receptor interacting protein 1 -0.0137733