Omeprazole_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.380703
NPSR1 neuropeptide S receptor 1 0.144102
ITGA6 integrin, alpha 6 0.126623
GMDS GDP-mannose 4,6-dehydratase 0.120995
MAML2 mastermind-like 2 (Drosophila) 0.120842
EMP1 epithelial membrane protein 1 0.109049
PDIA3 protein disulfide isomerase family A, member 3 0.104871
CEMIP cell migration inducing protein, hyaluronan binding 0.104597
EZR ezrin 0.102981
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0784869
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.077841
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0758441
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0726773
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0707413
KRT18 keratin 18, type I 0.0689199
FAT1 FAT atypical cadherin 1 0.0646293
APLP2 amyloid beta (A4) precursor-like protein 2 0.0632059
PGK1 phosphoglycerate kinase 1 0.0596981
VEGFA vascular endothelial growth factor A 0.0593022
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0579138
MBNL2 muscleblind-like splicing regulator 2 0.0569621
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0566484
ENO1 enolase 1, (alpha) 0.0548278
PKM pyruvate kinase, muscle 0.0544574
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0537701
AHR aryl hydrocarbon receptor 0.0511335
PDIA6 protein disulfide isomerase family A, member 6 0.050165
EHBP1 EH domain binding protein 1 0.0496142
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0492753
FLNB filamin B, beta 0.0489256
MYH9 myosin, heavy chain 9, non-muscle 0.0489021
ANXA2 annexin A2 0.0464027
ANXA1 annexin A1 0.0461842
TNIK TRAF2 and NCK interacting kinase 0.0444215
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0442578
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0431234
POTEF POTE ankyrin domain family, member F 0.0424154
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0410233
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0401933
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0396767
DSPP dentin sialophosphoprotein 0.039625
ANLN anillin, actin binding protein 0.0392497
FNDC3B fibronectin type III domain containing 3B 0.0385602
NCOR2 nuclear receptor corepressor 2 0.0379655
CALR calreticulin 0.0377519
AGR3 anterior gradient 3 0.0364599
COBL cordon-bleu WH2 repeat protein 0.0362388
ARHGAP32 Rho GTPase activating protein 32 0.0358385
PCBP2 poly(rC) binding protein 2 0.034929
KRT19 keratin 19, type I 0.0348244
CDK6 cyclin-dependent kinase 6 0.0347289
ASPH aspartate beta-hydroxylase 0.0337503
DSTN destrin (actin depolymerizing factor) 0.0334914
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0333695
CANX calnexin 0.0332768
ESYT2 extended synaptotagmin-like protein 2 0.033186
TRAK1 trafficking protein, kinesin binding 1 0.0320715
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0319856
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0319303
CCNY cyclin Y 0.0318891
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0318593
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0316592
MACF1 microtubule-actin crosslinking factor 1 0.0316231
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0314155
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.031287
ATXN1 ataxin 1 0.0312072
IQGAP1 IQ motif containing GTPase activating protein 1 0.0310867
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.030946
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0308341
AHNAK AHNAK nucleoprotein 0.0307622
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0299054
ADAM9 ADAM metallopeptidase domain 9 0.0295875
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0291648
ADD3 adducin 3 (gamma) 0.0291437
B2M beta-2-microglobulin 0.0288641
ARHGAP26 Rho GTPase activating protein 26 0.028592
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0285057
HYOU1 hypoxia up-regulated 1 0.0279713
SIK3 SIK family kinase 3 0.027925
TPM3 tropomyosin 3 0.0273394
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0271553
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0267157
RNF213 ring finger protein 213 0.0263306
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0260138
CD46 CD46 molecule, complement regulatory protein 0.0259595
KRT8 keratin 8, type II 0.0259398
TES testin LIM domain protein 0.025481
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.0254744
LDHA lactate dehydrogenase A 0.0253837
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0253292
INSIG1 insulin induced gene 1 0.0251186
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0248606
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0247488
WWC1 WW and C2 domain containing 1 0.0244202
NFE2L1 nuclear factor, erythroid 2-like 1 0.0243686
TMEM123 transmembrane protein 123 0.0242365
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0240666
SLK STE20-like kinase 0.0239796
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0239712
PDIA4 protein disulfide isomerase family A, member 4 0.0237915

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.071982
TMSB10 thymosin beta 10 -0.0683183
RPL23 ribosomal protein L23 -0.0486434
RPS25 ribosomal protein S25 -0.0420145
RPS19 ribosomal protein S19 -0.0407569
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0397946
RPL35A ribosomal protein L35a -0.0397125
RPL26 ribosomal protein L26 -0.0395459
S100P S100 calcium binding protein P -0.0354962
FTL ferritin, light polypeptide -0.0346728
RPLP1 ribosomal protein, large, P1 -0.0318638
RPL12 ribosomal protein L12 -0.0303429
RPL37A ribosomal protein L37a -0.0267978
RPS24 ribosomal protein S24 -0.0253854
RPS3 ribosomal protein S3 -0.0250651
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0250109
RPL34 ribosomal protein L34 -0.0249245
EIF1 eukaryotic translation initiation factor 1 -0.0235535
RPL19 ribosomal protein L19 -0.0230894
RPL30 ribosomal protein L30 -0.0229135
RPL18 ribosomal protein L18 -0.0226872
RPS8 ribosomal protein S8 -0.0223964
GPX2 glutathione peroxidase 2 -0.0222261
RPS6 ribosomal protein S6 -0.0214645
H1-0 H1.0 linker histone -0.0211004
RPL36 ribosomal protein L36 -0.020796
RPL36A ribosomal protein L36a -0.0207637
RPL35 ribosomal protein L35 -0.020497
RPLP2 ribosomal protein, large, P2 -0.0196088
HLA-C major histocompatibility complex, class I, C -0.0193947
RPL28 ribosomal protein L28 -0.0191998
RPS17 ribosomal protein S17 -0.018926
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0184594
RPS27 ribosomal protein S27 -0.0178447
RPS21 ribosomal protein S21 -0.0174251
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.017239
IER3 immediate early response 3 -0.0169525
LOC102724023 ES1 protein homolog, mitochondrial -0.0169198
RPL37 ribosomal protein L37 -0.0167268
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.016615
RPS16 ribosomal protein S16 -0.016432
RPL38 ribosomal protein L38 -0.0163311
RPS12 ribosomal protein S12 -0.0163173
RPL9 ribosomal protein L9 -0.0154823
PNISR PNN-interacting serine/arginine-rich protein -0.0154661
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0149285
RPS29 ribosomal protein S29 -0.0149181
RRBP1 ribosome binding protein 1 -0.0148087
RPS20 ribosomal protein S20 -0.0144101
RPS27A ribosomal protein S27a -0.0128664
SERF2 small EDRK-rich factor 2 -0.0124887
ATP5F1E ATP synthase F1 subunit epsilon -0.0122899
RPS5 ribosomal protein S5 -0.0122765
RPS14 ribosomal protein S14 -0.0122154
GNAS GNAS complex locus -0.0121961
RPL4 ribosomal protein L4 -0.0121644
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0121186
UBB ubiquitin B -0.0121064
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0120299
GSTP1 glutathione S-transferase pi 1 -0.0118727
RPL32 ribosomal protein L32 -0.0118535
RPL31 ribosomal protein L31 -0.0118019
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0115786
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.0115258
HLA-B major histocompatibility complex, class I, B -0.0114336
FAAH2 fatty acid amide hydrolase 2 -0.0113285
NT5C2 5'-nucleotidase, cytosolic II -0.011175
NDUFA4 NDUFA4, mitochondrial complex associated -0.0110458
RPS11 ribosomal protein S11 -0.0110244
EDF1 endothelial differentiation-related factor 1 -0.0108599
RPS4X ribosomal protein S4, X-linked -0.0108579
ROMO1 reactive oxygen species modulator 1 -0.010738
RPL27 ribosomal protein L27 -0.0107043
RPL5 ribosomal protein L5 -0.010689
ACTG1 actin gamma 1 -0.0106341
PRKN parkin RBR E3 ubiquitin protein ligase -0.0105968
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0105953
ALDOC aldolase C, fructose-bisphosphate -0.0105692
RB1CC1 RB1-inducible coiled-coil 1 -0.0105585
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0104748
SELENOK selenoprotein K -0.0104132
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0103267
RPL36AL ribosomal protein L36a-like -0.0102817
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0101687
COX5A cytochrome c oxidase subunit Va -0.0101046
PRRC2C proline-rich coiled-coil 2C -0.0100833
ERLEC1 endoplasmic reticulum lectin 1 -0.00980155
SENP5 SUMO1/sentrin specific peptidase 5 -0.00979778
AGR2 anterior gradient 2 -0.00970455
RAB1A RAB1A, member RAS oncogene family -0.00966613
S100A10 S100 calcium binding protein A10 -0.00965887
HMGB1 high mobility group box 1 -0.009645
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0096291
RPL8 ribosomal protein L8 -0.00959596
UBE2B ubiquitin-conjugating enzyme E2B -0.00954046
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.00945096
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.00939804
KLHL24 kelch-like family member 24 -0.0093042
ARF1 ADP-ribosylation factor 1 -0.00930091
RPLP0 ribosomal protein, large, P0 -0.00926431