Omeprazole_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.193991
ITGA6 integrin, alpha 6 0.149551
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.144195
FAT1 FAT atypical cadherin 1 0.141528
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.140043
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.130094
PABPC1 poly(A) binding protein, cytoplasmic 1 0.127551
SPTBN1 spectrin, beta, non-erythrocytic 1 0.124824
PTMA prothymosin, alpha 0.107904
EZR ezrin 0.106431
CEMIP cell migration inducing protein, hyaluronan binding 0.105487
LDHA lactate dehydrogenase A 0.103642
DSPP dentin sialophosphoprotein 0.101523
KRT18 keratin 18, type I 0.100374
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0993869
ENO1 enolase 1, (alpha) 0.0885197
TXNIP thioredoxin interacting protein 0.0859184
ANXA2 annexin A2 0.0838705
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0802899
LMO7 LIM domain 7 0.0760523
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0729777
MLEC malectin 0.0706964
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0703799
NPSR1 neuropeptide S receptor 1 0.0683271
PGK1 phosphoglycerate kinase 1 0.0679443
FAM13A family with sequence similarity 13, member A 0.0655592
CCNY cyclin Y 0.0651967
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0643553
GPHN gephyrin 0.0632458
ASPH aspartate beta-hydroxylase 0.0626727
GMDS GDP-mannose 4,6-dehydratase 0.0621424
CANX calnexin 0.0620331
EEF2 eukaryotic translation elongation factor 2 0.0616698
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0611468
MED13L mediator complex subunit 13-like 0.0603673
NDRG1 N-myc downstream regulated 1 0.0596609
NALF1 NALCN channel auxiliary factor 1 0.057732
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0574466
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.057239
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0556982
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0531417
CALR calreticulin 0.052912
PDIA3 protein disulfide isomerase family A, member 3 0.0521206
PKM pyruvate kinase, muscle 0.0516278
ANXA1 annexin A1 0.0503846
FLNB filamin B, beta 0.0501767
KIF5B kinesin family member 5B 0.0496915
EMP1 epithelial membrane protein 1 0.049416
GOLGA4 golgin A4 0.0489052
CD46 CD46 molecule, complement regulatory protein 0.0470924
PCBP2 poly(rC) binding protein 2 0.0468722
EPS8 epidermal growth factor receptor pathway substrate 8 0.0459125
UBA6 ubiquitin-like modifier activating enzyme 6 0.0453637
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0452763
ESYT2 extended synaptotagmin-like protein 2 0.0448024
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0444328
ITPRID2 ITPR interacting domain containing 2 0.0442542
IQGAP1 IQ motif containing GTPase activating protein 1 0.0440143
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0438518
MACF1 microtubule-actin crosslinking factor 1 0.0436231
KRT19 keratin 19, type I 0.0435865
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0430395
KRT8 keratin 8, type II 0.0430306
TRIM2 tripartite motif containing 2 0.0420777
AHNAK AHNAK nucleoprotein 0.0413321
PIGR polymeric immunoglobulin receptor 0.0404143
RNF145 ring finger protein 145 0.0403576
MBNL2 muscleblind-like splicing regulator 2 0.0399656
VEGFA vascular endothelial growth factor A 0.0395819
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0393707
VMP1 vacuole membrane protein 1 0.0388012
PDIA6 protein disulfide isomerase family A, member 6 0.0377495
AFF1 AF4/FMR2 family, member 1 0.0376353
FNDC3B fibronectin type III domain containing 3B 0.0369509
SETD5 SET domain containing 5 0.0364839
NCOR1 nuclear receptor corepressor 1 0.0364647
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0364276
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0363
EPCAM epithelial cell adhesion molecule 0.0357702
WAC WW domain containing adaptor with coiled-coil 0.0357059
CSNK1A1 casein kinase 1, alpha 1 0.0355256
ZNF292 zinc finger protein 292 0.0353752
PPARG peroxisome proliferator-activated receptor gamma 0.0349111
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0347754
UBE2H ubiquitin-conjugating enzyme E2H 0.0346871
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0343342
PTBP3 polypyrimidine tract binding protein 3 0.0339392
FNBP1L formin binding protein 1-like 0.033493
TTC3 tetratricopeptide repeat domain 3 0.0332482
CLTC clathrin, heavy chain (Hc) 0.0331825
TPM3 tropomyosin 3 0.0327708
ANKRD17 ankyrin repeat domain 17 0.0324646
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0323717
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0323603
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0323334
MBNL1 muscleblind-like splicing regulator 1 0.0320947
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0318808
MYH9 myosin, heavy chain 9, non-muscle 0.0318667
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0318473
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0315269

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0808699
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0416131
TMSB10 thymosin beta 10 -0.0403131
RPLP1 ribosomal protein, large, P1 -0.0356721
RPL35A ribosomal protein L35a -0.0336089
RPS12 ribosomal protein S12 -0.0312428
RPL36 ribosomal protein L36 -0.0303135
RPL9 ribosomal protein L9 -0.0294295
RPLP2 ribosomal protein, large, P2 -0.029337
RPL26 ribosomal protein L26 -0.0292868
RPS6 ribosomal protein S6 -0.0278261
RPL34 ribosomal protein L34 -0.0258235
RPS24 ribosomal protein S24 -0.0257449
RPS8 ribosomal protein S8 -0.0249115
RPS19 ribosomal protein S19 -0.0234001
RPL37A ribosomal protein L37a -0.0218678
ISG15 ISG15 ubiquitin-like modifier -0.0205696
MT2A metallothionein 2A -0.0190559
S100P S100 calcium binding protein P -0.018495
ACTG1 actin gamma 1 -0.0183043
RPL23 ribosomal protein L23 -0.0174926
RPL30 ribosomal protein L30 -0.0166401
FTL ferritin, light polypeptide -0.0159071
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0158773
HMGB1 high mobility group box 1 -0.0154713
RPS25 ribosomal protein S25 -0.0154621
RPS27 ribosomal protein S27 -0.0153973
RPL28 ribosomal protein L28 -0.0151627
PRSS3 protease, serine, 3 -0.0149523
RPS17 ribosomal protein S17 -0.0139615
RPS29 ribosomal protein S29 -0.013713
RIGI RNA sensor RIG-I -0.0133293
RPL27 ribosomal protein L27 -0.0129852
RPL38 ribosomal protein L38 -0.0123645
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0119578
RPS20 ribosomal protein S20 -0.011845
RPL37 ribosomal protein L37 -0.0117697
RPS3 ribosomal protein S3 -0.0115771
RPL5 ribosomal protein L5 -0.0114539
RPL35 ribosomal protein L35 -0.0113825
IER3 immediate early response 3 -0.0108662
RPS27A ribosomal protein S27a -0.0106564
RPS16 ribosomal protein S16 -0.0104319
ONECUT3 one cut homeobox 3 -0.010145
RPL13A ribosomal protein L13a -0.0100071
RPL36AL ribosomal protein L36a-like -0.00988688
RPL36A ribosomal protein L36a -0.00961589
TFF1 trefoil factor 1 -0.00916886
PCED1B PC-esterase domain containing 1B -0.00892564
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.00879751
RPS21 ribosomal protein S21 -0.00879354
TRAPPC12 trafficking protein particle complex 12 -0.00874632
RPL7A ribosomal protein L7a -0.00872755
RPL31 ribosomal protein L31 -0.00822418
RPS26 ribosomal protein S26 -0.0080038
FAF1 Fas (TNFRSF6) associated factor 1 -0.00773035
LRRK1 leucine-rich repeat kinase 1 -0.00772219
ZNF254 zinc finger protein 254 -0.00772143
RPL18 ribosomal protein L18 -0.00771795
PRMT2 protein arginine methyltransferase 2 -0.00770112
SAMD4A sterile alpha motif domain containing 4A -0.00762415
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00748338
AHI1 Abelson helper integration site 1 -0.00740484
POF1B premature ovarian failure, 1B -0.00737317
GPC6 glypican 6 -0.00726163
ZBTB7A zinc finger and BTB domain containing 7A -0.00721905
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -0.00721468
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.00718811
PPARA peroxisome proliferator-activated receptor alpha -0.00714101
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.00708596
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.00706615
BMAL2 basic helix-loop-helix ARNT like 2 -0.00699131
AOPEP aminopeptidase O (putative) -0.0069858
MRPL33 mitochondrial ribosomal protein L33 -0.00691405
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.00682798
TMEM45B transmembrane protein 45B -0.00681763
HMGXB4 HMG box domain containing 4 -0.0066134
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0065817
ENOSF1 enolase superfamily member 1 -0.00657789
RPS28 ribosomal protein S28 -0.00650485
NSRP1 nuclear speckle splicing regulatory protein 1 -0.00649988
ANTXR2 anthrax toxin receptor 2 -0.00647429
MIDN midnolin -0.00637241
TEP1 telomerase-associated protein 1 -0.00636587
GNAS GNAS complex locus -0.00635148
KIAA1217 KIAA1217 -0.00634964
MMP24OS MMP24 opposite strand -0.00617901
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00613447
RPS13 ribosomal protein S13 -0.00612929
LURAP1L leucine rich adaptor protein 1-like -0.0061079
RPL41 ribosomal protein L41 -0.00605438
RPS14 ribosomal protein S14 -0.00603778
RPL6 ribosomal protein L6 -0.00599066
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.00593235
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.00589938
H1-4 H1.4 linker histone, cluster member -0.00589088
FAAH2 fatty acid amide hydrolase 2 -0.0058522
CHAF1A chromatin assembly factor 1, subunit A (p150) -0.00581845
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.00576366
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.00572808