Omeprazole_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.13471
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110939
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0987897
ERRFI1 ERBB receptor feedback inhibitor 1 0.08683
FMNL2 formin-like 2 0.0845228
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0715122
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0657207
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0630952
POTEF POTE ankyrin domain family, member F 0.0586887
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0578344
PSD3 pleckstrin and Sec7 domain containing 3 0.055594
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0553844
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0552899
EZR ezrin 0.0551315
SPAG9 sperm associated antigen 9 0.0541786
ENO1 enolase 1, (alpha) 0.0537682
DOCK11 dedicator of cytokinesis 11 0.051912
DPYD dihydropyrimidine dehydrogenase 0.0517388
MYOF myoferlin 0.0492919
PCBP2 poly(rC) binding protein 2 0.0481399
YEATS2 YEATS domain containing 2 0.0472346
TSC22D1 TSC22 domain family, member 1 0.0465003
ESYT2 extended synaptotagmin-like protein 2 0.0455946
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0446528
CANX calnexin 0.0438045
MACF1 microtubule-actin crosslinking factor 1 0.0433952
XPO1 exportin 1 0.04308
FNIP1 folliculin interacting protein 1 0.0428004
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0415277
ZNF292 zinc finger protein 292 0.041504
PIAS2 protein inhibitor of activated STAT, 2 0.0406568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0405327
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0400748
PKM pyruvate kinase, muscle 0.0397507
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0396825
P4HB prolyl 4-hydroxylase, beta polypeptide 0.039527
APP amyloid beta (A4) precursor protein 0.0394743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0393004
PRELID2 PRELI domain containing 2 0.0389598
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0388644
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0388578
ADGRG6 adhesion G protein-coupled receptor G6 0.0385544
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0385199
CAPRIN2 caprin family member 2 0.0383404
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0376164
MYH9 myosin, heavy chain 9, non-muscle 0.0367272
EXOC4 exocyst complex component 4 0.0366771
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0363736
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0363085
APLP2 amyloid beta (A4) precursor-like protein 2 0.0354204
ADAM10 ADAM metallopeptidase domain 10 0.0353823
RAD51B RAD51 paralog B 0.0350562
KMT2C lysine (K)-specific methyltransferase 2C 0.0350554
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0349343
ARRDC3 arrestin domain containing 3 0.0348127
CENPF centromere protein F, 350/400kDa 0.0348038
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0340669
PLK2 polo-like kinase 2 0.0337665
KDM2A lysine (K)-specific demethylase 2A 0.0335318
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0335287
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0331164
KTN1 kinectin 1 (kinesin receptor) 0.0327613
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0322805
MSN moesin 0.0322348
MBNL2 muscleblind-like splicing regulator 2 0.0319669
PTK2 protein tyrosine kinase 2 0.0318322
CSNK1A1 casein kinase 1, alpha 1 0.0318127
HELZ helicase with zinc finger 0.0316324
DLG1 discs, large homolog 1 (Drosophila) 0.031466
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0311247
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0309782
SLK STE20-like kinase 0.0308119
MYO10 myosin X 0.0302784
FNDC3B fibronectin type III domain containing 3B 0.0300961
AKAP9 A kinase (PRKA) anchor protein 9 0.029953
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.029913
ZNF148 zinc finger protein 148 0.029892
EEF2 eukaryotic translation elongation factor 2 0.0298727
RERE arginine-glutamic acid dipeptide (RE) repeats 0.028997
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0288787
TXNIP thioredoxin interacting protein 0.0287964
CDK19 cyclin-dependent kinase 19 0.0286254
ANXA1 annexin A1 0.0279966
EFNA5 ephrin-A5 0.0277322
GOLGA4 golgin A4 0.0276864
BIRC6 baculoviral IAP repeat containing 6 0.0272999
IQGAP1 IQ motif containing GTPase activating protein 1 0.0270686
KDM4C lysine (K)-specific demethylase 4C 0.0270191
CADM2 cell adhesion molecule 2 0.0268003
MATR3 matrin 3 0.0266499
CD109 CD109 molecule 0.0265786
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0262431
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0261507
ADAM17 ADAM metallopeptidase domain 17 0.0261121
PTPRJ protein tyrosine phosphatase, receptor type, J 0.026067
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0258983
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0257203
PGK1 phosphoglycerate kinase 1 0.0257201
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0252093
TPM3 tropomyosin 3 0.0251701

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.188792
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168286
MT2A metallothionein 2A -0.162855
VIM vimentin -0.107223
TPT1 tumor protein, translationally-controlled 1 -0.0788888
PTMA prothymosin, alpha -0.0782486
RPL35A ribosomal protein L35a -0.0715652
TM4SF1 transmembrane 4 L six family member 1 -0.0682019
RPS8 ribosomal protein S8 -0.0643861
FTL ferritin, light polypeptide -0.0622057
RPL12 ribosomal protein L12 -0.0566135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529114
RPS19 ribosomal protein S19 -0.0523663
RPL23 ribosomal protein L23 -0.0519443
RPL36 ribosomal protein L36 -0.0519262
ACTG1 actin gamma 1 -0.0488697
RPL26 ribosomal protein L26 -0.0487068
RPLP1 ribosomal protein, large, P1 -0.046834
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0455377
RPL37A ribosomal protein L37a -0.0447378
RPS6 ribosomal protein S6 -0.0444453
MT1E metallothionein 1E -0.0442644
MT1X metallothionein 1X -0.0427446
RPLP2 ribosomal protein, large, P2 -0.0427445
TXNRD1 thioredoxin reductase 1 -0.0416699
RPL31 ribosomal protein L31 -0.0399405
RPL19 ribosomal protein L19 -0.0370905
LOC112694756 uncharaterized LOC112694756 -0.03541
HLA-B major histocompatibility complex, class I, B -0.0348606
RACK1 receptor for activated C kinase 1 -0.0337167
RPS24 ribosomal protein S24 -0.0332145
RPS3 ribosomal protein S3 -0.0330158
RPS12 ribosomal protein S12 -0.0326539
RPS27A ribosomal protein S27a -0.032623
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0324594
EIF1 eukaryotic translation initiation factor 1 -0.0322572
RPL36A ribosomal protein L36a -0.0317902
RPL34 ribosomal protein L34 -0.0312268
EGR1 early growth response 1 -0.0304917
RPL5 ribosomal protein L5 -0.0303767
RPL35 ribosomal protein L35 -0.0295183
RPL37 ribosomal protein L37 -0.0289968
RPS29 ribosomal protein S29 -0.0284887
RPL18 ribosomal protein L18 -0.0266299
RPS25 ribosomal protein S25 -0.0262041
RPL28 ribosomal protein L28 -0.0261012
RPS20 ribosomal protein S20 -0.0250367
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0249701
RPS14 ribosomal protein S14 -0.024461
RPS16 ribosomal protein S16 -0.0243868
RPL9 ribosomal protein L9 -0.023913
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0228429
FTH1 ferritin, heavy polypeptide 1 -0.0220941
RPS23 ribosomal protein S23 -0.0219359
RPL7A ribosomal protein L7a -0.0217575
RPL38 ribosomal protein L38 -0.0216773
RPS28 ribosomal protein S28 -0.0209227
S100A6 S100 calcium binding protein A6 -0.0206202
RPL32 ribosomal protein L32 -0.0203793
RPS27 ribosomal protein S27 -0.0202466
RPL27 ribosomal protein L27 -0.0196561
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0192729
RPS5 ribosomal protein S5 -0.0184484
RPL11 ribosomal protein L11 -0.0183423
RPLP0 ribosomal protein, large, P0 -0.0181818
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0181604
KLF6 Kruppel-like factor 6 -0.0180409
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0178986
RPS17 ribosomal protein S17 -0.0178537
RPS4X ribosomal protein S4, X-linked -0.017166
RPS13 ribosomal protein S13 -0.0168052
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0164092
RPL8 ribosomal protein L8 -0.0163208
EIF5B eukaryotic translation initiation factor 5B -0.01611
RPS10 ribosomal protein S10 -0.0159859
RPL39 ribosomal protein L39 -0.0157568
NAP1L1 nucleosome assembly protein 1-like 1 -0.0156753
RPL13A ribosomal protein L13a -0.0156409
ZBTB38 zinc finger and BTB domain containing 38 -0.0155866
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0153906
RPS15 ribosomal protein S15 -0.0153554
OSMR oncostatin M receptor -0.0152827
RPL4 ribosomal protein L4 -0.0145699
SRGN serglycin -0.0144783
RPL30 ribosomal protein L30 -0.01445
HMGB1 high mobility group box 1 -0.014364
HMGA1 high mobility group AT-hook 1 -0.0143214
IFITM3 interferon induced transmembrane protein 3 -0.0143021
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0142749
RPS21 ribosomal protein S21 -0.0140995
PRDX1 peroxiredoxin 1 -0.0140023
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0139716
S100A9 S100 calcium binding protein A9 -0.0136269
ARF1 ADP-ribosylation factor 1 -0.0135271
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0134509
LOC102724023 ES1 protein homolog, mitochondrial -0.013294
MRPL13 mitochondrial ribosomal protein L13 -0.01329
NACA nascent polypeptide-associated complex alpha subunit -0.0132171
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0131445
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0129529