Omeprazole_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.361153
THSD4 thrombospondin, type I, domain containing 4 0.160333
ASPH aspartate beta-hydroxylase 0.142503
PTPRM protein tyrosine phosphatase, receptor type, M 0.123957
LMO7 LIM domain 7 0.121587
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0799806
CXCL8 chemokine (C-X-C motif) ligand 8 0.0760538
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0757037
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0744123
FNDC3B fibronectin type III domain containing 3B 0.0730742
PDE4D phosphodiesterase 4D, cAMP-specific 0.0725885
SLTM SAFB-like, transcription modulator 0.0643217
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0636709
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0595137
DSPP dentin sialophosphoprotein 0.0584779
MYOF myoferlin 0.0582028
IGFBP5 insulin-like growth factor binding protein 5 0.057281
LDHA lactate dehydrogenase A 0.0571876
CAV1 caveolin 1, caveolae protein, 22kDa 0.054961
PDLIM5 PDZ and LIM domain 5 0.0536534
ERRFI1 ERBB receptor feedback inhibitor 1 0.0526423
GRAMD1B GRAM domain containing 1B 0.0525608
LAMC2 laminin, gamma 2 0.052556
ANXA2 annexin A2 0.0525336
LAMA4 laminin, alpha 4 0.0517364
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0514035
BZW1 basic leucine zipper and W2 domains 1 0.0501313
KRT18 keratin 18, type I 0.0498376
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0486735
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0478707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0467568
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0461835
ACTG1 actin gamma 1 0.0451013
MACF1 microtubule-actin crosslinking factor 1 0.0445576
SCEL sciellin 0.0440075
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0440038
MYO1E myosin IE 0.0430965
PM20D1 peptidase M20 domain containing 1 0.0419926
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0416602
TES testin LIM domain protein 0.0408356
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0407731
EFNA5 ephrin-A5 0.0404897
VCL vinculin 0.0401948
NPAS2 neuronal PAS domain protein 2 0.038539
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0380071
AKAP12 A kinase (PRKA) anchor protein 12 0.0371277
INTS6 integrator complex subunit 6 0.0365787
MAML3 mastermind-like 3 (Drosophila) 0.0350059
LPP LIM domain containing preferred translocation partner in lipoma 0.0349722
IGFBP3 insulin-like growth factor binding protein 3 0.034678
RIMS2 regulating synaptic membrane exocytosis 2 0.0342986
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0342081
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0340253
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0339457
OSMR oncostatin M receptor 0.03384
PKM pyruvate kinase, muscle 0.033757
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0333959
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0332601
BCAR3 breast cancer anti-estrogen resistance 3 0.0329717
KRT7 keratin 7, type II 0.0313387
RAB27B RAB27B, member RAS oncogene family 0.030708
TPM4 tropomyosin 4 0.0303999
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.029967
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0297709
AKAP13 A kinase (PRKA) anchor protein 13 0.029711
PYGL phosphorylase, glycogen, liver 0.0294995
LGALS12 lectin, galactoside-binding, soluble, 12 0.0293906
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0293393
CAV2 caveolin 2 0.0293254
SVIL supervillin 0.0288756
CUX1 cut-like homeobox 1 0.0281336
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0279134
S100A10 S100 calcium binding protein A10 0.0277188
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.027413
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027355
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0272326
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0269062
SIK3 SIK family kinase 3 0.0268111
EGR1 early growth response 1 0.0268077
DOCK5 dedicator of cytokinesis 5 0.0264293
FOXP1 forkhead box P1 0.0263733
CCND1 cyclin D1 0.0263642
IGF1R insulin-like growth factor 1 receptor 0.0257652
CEMIP cell migration inducing protein, hyaluronan binding 0.0257226
PRKCA protein kinase C, alpha 0.0256926
SAMD4A sterile alpha motif domain containing 4A 0.0251072
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0249363
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0248534
GSK3B glycogen synthase kinase 3 beta 0.0248168
EHBP1 EH domain binding protein 1 0.0243908
RAD51B RAD51 paralog B 0.0239999
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.023942
TBC1D5 TBC1 domain family, member 5 0.0238088
TRIO trio Rho guanine nucleotide exchange factor 0.0237862
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0236219
NTSR1 neurotensin receptor 1 (high affinity) 0.0235732
MCL1 myeloid cell leukemia 1 0.0232572
POTEF POTE ankyrin domain family, member F 0.0226975
ZSWIM6 zinc finger, SWIM-type containing 6 0.0226266
CCSER1 coiled-coil serine-rich protein 1 0.0226063

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.0967807
MT2A metallothionein 2A -0.0735136
RPS3 ribosomal protein S3 -0.0665698
TPT1 tumor protein, translationally-controlled 1 -0.062552
RPS27A ribosomal protein S27a -0.0528894
FTL ferritin, light polypeptide -0.0516694
TXNRD1 thioredoxin reductase 1 -0.046093
NAMPT nicotinamide phosphoribosyltransferase -0.045259
RPLP1 ribosomal protein, large, P1 -0.0394059
RPL37A ribosomal protein L37a -0.0389681
TMEM165 transmembrane protein 165 -0.0384646
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0355643
PRRC2C proline-rich coiled-coil 2C -0.0345452
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0331054
RPS8 ribosomal protein S8 -0.0328589
NDRG1 N-myc downstream regulated 1 -0.0317534
RPS12 ribosomal protein S12 -0.029119
EEF2 eukaryotic translation elongation factor 2 -0.0286224
EIF1 eukaryotic translation initiation factor 1 -0.0281159
FTH1 ferritin, heavy polypeptide 1 -0.0280668
RPS25 ribosomal protein S25 -0.0276075
OGA O-GlcNAcase -0.0272483
AKR1C1 aldo-keto reductase family 1, member C1 -0.0268667
RPS24 ribosomal protein S24 -0.0267891
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0267002
RPL34 ribosomal protein L34 -0.0266166
TMSB10 thymosin beta 10 -0.0263425
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0245416
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0244688
AGO2 argonaute RISC catalytic component 2 -0.0242776
PTMA prothymosin, alpha -0.023978
WDR45B WD repeat domain 45B -0.0237969
RUNX1 runt-related transcription factor 1 -0.0233898
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0232225
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0231116
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0228785
RPL31 ribosomal protein L31 -0.0224348
RPL35A ribosomal protein L35a -0.0223922
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0223919
PNISR PNN-interacting serine/arginine-rich protein -0.0221392
PCBP2 poly(rC) binding protein 2 -0.0216003
RPL23 ribosomal protein L23 -0.0211662
ANKRD10 ankyrin repeat domain 10 -0.0208636
RPL5 ribosomal protein L5 -0.0206755
B2M beta-2-microglobulin -0.0205975
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0202031
RPL12 ribosomal protein L12 -0.0198728
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0196979
RPL37 ribosomal protein L37 -0.0196735
MT1X metallothionein 1X -0.019539
RPL8 ribosomal protein L8 -0.0187751
RPS19 ribosomal protein S19 -0.0186807
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0185956
SEC61G Sec61 gamma subunit -0.0181028
CCNI cyclin I -0.0177262
RPLP2 ribosomal protein, large, P2 -0.0175198
CSNK1E casein kinase 1, epsilon -0.0170935
RPL19 ribosomal protein L19 -0.017053
RPL26 ribosomal protein L26 -0.017049
S100P S100 calcium binding protein P -0.0170399
RPS29 ribosomal protein S29 -0.0170335
RPS17 ribosomal protein S17 -0.0169648
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0168899
RPLP0 ribosomal protein, large, P0 -0.0167198
SLC38A1 solute carrier family 38, member 1 -0.016675
CAMTA1 calmodulin binding transcription activator 1 -0.0163793
RNMT RNA (guanine-7-) methyltransferase -0.0161436
RPL30 ribosomal protein L30 -0.0159588
RPS27 ribosomal protein S27 -0.0159501
ZFC3H1 zinc finger, C3H1-type containing -0.0159125
ARGLU1 arginine and glutamate rich 1 -0.0157979
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0157532
RPL9 ribosomal protein L9 -0.0154528
RPS16 ribosomal protein S16 -0.0154181
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0153043
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0152756
WSB1 WD repeat and SOCS box containing 1 -0.0150959
FOSL1 FOS-like antigen 1 -0.0147935
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.014705
RPL36 ribosomal protein L36 -0.0144167
RPS6 ribosomal protein S6 -0.0142432
RACK1 receptor for activated C kinase 1 -0.0140188
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0137656
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0135917
RPL36A ribosomal protein L36a -0.0135685
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0131123
EEF1G eukaryotic translation elongation factor 1 gamma -0.0130867
RPS23 ribosomal protein S23 -0.0130715
RNF24 ring finger protein 24 -0.0130668
WDR26 WD repeat domain 26 -0.0129164
MKI67 marker of proliferation Ki-67 -0.012913
RTN4 reticulon 4 -0.0128542
ZC3H15 zinc finger CCCH-type containing 15 -0.0128478
UVRAG UV radiation resistance associated -0.0128039
RPS13 ribosomal protein S13 -0.0127679
KDM3A lysine (K)-specific demethylase 3A -0.0127063
TKT transketolase -0.0126998
UBE2B ubiquitin-conjugating enzyme E2B -0.0126481
F11R F11 receptor -0.012633
RBM39 RNA binding motif protein 39 -0.0125444