Omeprazole_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.174334
GOLGA4 golgin A4 0.0960905
SOD2 superoxide dismutase 2, mitochondrial 0.0939412
NAMPT nicotinamide phosphoribosyltransferase 0.0807349
FNDC3B fibronectin type III domain containing 3B 0.0712561
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0705376
PCBP2 poly(rC) binding protein 2 0.0691249
GPC6 glypican 6 0.0663087
FAM13A family with sequence similarity 13, member A 0.0651282
PRELID2 PRELI domain containing 2 0.0624347
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0597923
CANX calnexin 0.0589076
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0556725
DSCAM Down syndrome cell adhesion molecule 0.0520791
PDIA3 protein disulfide isomerase family A, member 3 0.0500341
RBM39 RNA binding motif protein 39 0.0493399
MYOF myoferlin 0.0456965
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.044614
NCOA7 nuclear receptor coactivator 7 0.0442038
ARF4 ADP-ribosylation factor 4 0.0441156
SEC31A SEC31 homolog A (S. cerevisiae) 0.0439684
DDIT3 DNA-damage-inducible transcript 3 0.043354
ERRFI1 ERBB receptor feedback inhibitor 1 0.0398649
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0395972
DLG1 discs, large homolog 1 (Drosophila) 0.039177
KDM3A lysine (K)-specific demethylase 3A 0.0372433
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0368717
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0366566
OGA O-GlcNAcase 0.0366036
ZNF292 zinc finger protein 292 0.0362928
KMT2C lysine (K)-specific methyltransferase 2C 0.0355287
SRP54 signal recognition particle 54kDa 0.0350075
ELL2 elongation factor, RNA polymerase II, 2 0.0346017
CD109 CD109 molecule 0.0345524
EZR ezrin 0.0340265
AKAP9 A kinase (PRKA) anchor protein 9 0.0337058
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0333741
MORF4L2 mortality factor 4 like 2 0.0327085
RAD51B RAD51 paralog B 0.032495
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0320684
SQSTM1 sequestosome 1 0.0317715
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0315414
SMAD3 SMAD family member 3 0.0312061
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0310845
FBXL13 F-box and leucine-rich repeat protein 13 0.0307269
MYH9 myosin, heavy chain 9, non-muscle 0.0299602
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298257
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0297632
COPB1 coatomer protein complex, subunit beta 1 0.0297251
CTNND1 catenin (cadherin-associated protein), delta 1 0.0295221
NBAS neuroblastoma amplified sequence 0.0291997
MCL1 myeloid cell leukemia 1 0.0291134
TRIO trio Rho guanine nucleotide exchange factor 0.0289776
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0286497
COPA coatomer protein complex, subunit alpha 0.0286449
TTC3 tetratricopeptide repeat domain 3 0.0286136
HDLBP high density lipoprotein binding protein 0.0280275
NAV2 neuron navigator 2 0.0276535
MON2 MON2 homolog (S. cerevisiae) 0.0275071
SUCO SUN domain containing ossification factor 0.0274404
COG5 component of oligomeric golgi complex 5 0.0274084
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0269628
SBF2 SET binding factor 2 0.0269445
NDRG1 N-myc downstream regulated 1 0.026889
ENO1 enolase 1, (alpha) 0.0263398
TNNC1 troponin C type 1 (slow) 0.0261164
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0258378
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0256556
SEC24A SEC24 family member A 0.0253972
HELZ helicase with zinc finger 0.0253107
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0251716
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0248858
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0247762
APLP2 amyloid beta (A4) precursor-like protein 2 0.024776
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024723
SPAG9 sperm associated antigen 9 0.0246474
LMAN1 lectin, mannose-binding, 1 0.0246287
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0244638
KDM2A lysine (K)-specific demethylase 2A 0.0240095
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0239318
ASPH aspartate beta-hydroxylase 0.0238048
ARRDC3 arrestin domain containing 3 0.0237995
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0237479
YME1L1 YME1-like 1 ATPase 0.0237007
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.023599
VCL vinculin 0.0234084
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0233849
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0232896
HDAC9 histone deacetylase 9 0.0231579
GDI2 GDP dissociation inhibitor 2 0.0231486
BIRC6 baculoviral IAP repeat containing 6 0.0231365
TBC1D15 TBC1 domain family, member 15 0.0230374
TP53BP1 tumor protein p53 binding protein 1 0.0224922
VMP1 vacuole membrane protein 1 0.0223627
TBC1D5 TBC1 domain family, member 5 0.0222812
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0221932
CALU calumenin 0.0221761
LDHA lactate dehydrogenase A 0.0221755
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0221283
RAB8B RAB8B, member RAS oncogene family 0.0220672

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.214744
VIM vimentin -0.144163
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.106809
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.106536
NRG1 neuregulin 1 -0.0991676
MTSS1 metastasis suppressor 1 -0.0961268
HMGA2 high mobility group AT-hook 2 -0.0909619
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0908814
FTL ferritin, light polypeptide -0.0877677
TFPI2 tissue factor pathway inhibitor 2 -0.0877627
DPYD dihydropyrimidine dehydrogenase -0.0860233
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0851768
ANTXR2 anthrax toxin receptor 2 -0.0819847
CDH13 cadherin 13 -0.081359
GLCCI1 glucocorticoid induced 1 -0.0798473
SDK1 sidekick cell adhesion molecule 1 -0.0797512
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0790707
STC1 stanniocalcin 1 -0.0789804
MT2A metallothionein 2A -0.0785987
NRP1 neuropilin 1 -0.0767059
RPLP1 ribosomal protein, large, P1 -0.0731051
RPS19 ribosomal protein S19 -0.0710984
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0673034
ARHGAP5 Rho GTPase activating protein 5 -0.0635314
S100A6 S100 calcium binding protein A6 -0.0614153
RPL36 ribosomal protein L36 -0.0595083
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0573588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0556259
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0555734
AKAP12 A kinase (PRKA) anchor protein 12 -0.0548729
VRK2 vaccinia related kinase 2 -0.054439
CLMP CXADR-like membrane protein -0.0543643
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0536796
AKAP13 A kinase (PRKA) anchor protein 13 -0.0519095
RPS12 ribosomal protein S12 -0.0517876
RPS6 ribosomal protein S6 -0.0515767
PTMA prothymosin, alpha -0.0501285
SNX9 sorting nexin 9 -0.0478848
PTK2 protein tyrosine kinase 2 -0.0470324
IL1B interleukin 1, beta -0.0461288
IGFBP3 insulin-like growth factor binding protein 3 -0.0461042
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0444177
RPLP2 ribosomal protein, large, P2 -0.0436264
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0430772
RPL34 ribosomal protein L34 -0.0422016
NUMB numb homolog (Drosophila) -0.0414312
B2M beta-2-microglobulin -0.0411898
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0410974
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0406625
TRPS1 trichorhinophalangeal syndrome I -0.0403904
PRRX1 paired related homeobox 1 -0.0398406
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0388945
RPS21 ribosomal protein S21 -0.0387568
WSB1 WD repeat and SOCS box containing 1 -0.038017
ZEB2 zinc finger E-box binding homeobox 2 -0.0380153
ANXA10 annexin A10 -0.0375848
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0373537
CDK14 cyclin-dependent kinase 14 -0.0368796
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0365963
OSMR oncostatin M receptor -0.0363797
RPL37A ribosomal protein L37a -0.0362804
RPL18 ribosomal protein L18 -0.0355601
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0352958
FTH1 ferritin, heavy polypeptide 1 -0.0351416
TPT1 tumor protein, translationally-controlled 1 -0.0344545
PNRC1 proline-rich nuclear receptor coactivator 1 -0.034361
RPL23 ribosomal protein L23 -0.0343062
BMERB1 bMERB domain containing 1 -0.0342542
MSRB3 methionine sulfoxide reductase B3 -0.0341331
SOX4 SRY (sex determining region Y)-box 4 -0.0334587
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0333796
RPS27 ribosomal protein S27 -0.0332976
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0330608
FRMD4A FERM domain containing 4A -0.0330013
TMEM165 transmembrane protein 165 -0.0329808
RPS8 ribosomal protein S8 -0.0329507
RPL35A ribosomal protein L35a -0.0325257
WWC2 WW and C2 domain containing 2 -0.0324622
LGALS1 lectin, galactoside-binding, soluble, 1 -0.032257
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0318504
RPS3 ribosomal protein S3 -0.0318477
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0316984
RPL12 ribosomal protein L12 -0.0316332
IFI44L interferon-induced protein 44-like -0.0312374
C15ORF48 chromosome 15 open reading frame 48 -0.0302176
SIK3 SIK family kinase 3 -0.0300998
NAV3 neuron navigator 3 -0.0299825
RPL28 ribosomal protein L28 -0.0298309
LTBP1 latent transforming growth factor beta binding protein 1 -0.0297684
KTN1 kinectin 1 (kinesin receptor) -0.029755
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0297363
RPS29 ribosomal protein S29 -0.0295367
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0295151
MAML3 mastermind-like 3 (Drosophila) -0.0294445
FNBP1 formin binding protein 1 -0.0294395
GLIS3 GLIS family zinc finger 3 -0.0289747
TM4SF1 transmembrane 4 L six family member 1 -0.0289616
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0287829
NPAS2 neuronal PAS domain protein 2 -0.0282256
RPL31 ribosomal protein L31 -0.02791