Omeprazole_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.191387
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.153134
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.151693
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.141646
FTL ferritin, light polypeptide 0.11114
FTH1 ferritin, heavy polypeptide 1 0.0947548
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0787432
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0782648
FNDC3B fibronectin type III domain containing 3B 0.0643833
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0603786
ANXA1 annexin A1 0.0583995
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0568103
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0554939
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0551422
PDIA3 protein disulfide isomerase family A, member 3 0.0530059
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0507718
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0503515
PKM pyruvate kinase, muscle 0.0502791
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0501044
IGFBP3 insulin-like growth factor binding protein 3 0.0497577
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0495702
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0481379
SMOC1 SPARC related modular calcium binding 1 0.0480508
FGB fibrinogen beta chain 0.0470081
RBM39 RNA binding motif protein 39 0.0464944
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0464623
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0458123
PYGL phosphorylase, glycogen, liver 0.0447549
BASP1 brain abundant, membrane attached signal protein 1 0.0442799
LDHA lactate dehydrogenase A 0.0438001
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0435407
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0429745
ANXA2 annexin A2 0.0426674
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0421197
DOCK4 dedicator of cytokinesis 4 0.0413675
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0401182
MCL1 myeloid cell leukemia 1 0.039413
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0391312
FMNL2 formin-like 2 0.0383178
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0380562
PARD3 par-3 family cell polarity regulator 0.0376656
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0375432
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0375398
WAC WW domain containing adaptor with coiled-coil 0.0374003
FNBP1L formin binding protein 1-like 0.0368547
RAB7A RAB7A, member RAS oncogene family 0.0355823
VEZT vezatin, adherens junctions transmembrane protein 0.0355802
EIF1 eukaryotic translation initiation factor 1 0.0349058
UGCG UDP-glucose ceramide glucosyltransferase 0.0346216
ELL2 elongation factor, RNA polymerase II, 2 0.0343218
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0335778
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.033283
COPA coatomer protein complex, subunit alpha 0.0332777
SFTPA2 surfactant protein A2 0.0331875
BZW2 basic leucine zipper and W2 domains 2 0.0331695
CALR calreticulin 0.0324018
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0323236
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0321754
TRA2A transformer 2 alpha homolog (Drosophila) 0.0320824
KTN1 kinectin 1 (kinesin receptor) 0.0320727
IQGAP1 IQ motif containing GTPase activating protein 1 0.0320592
PDLIM5 PDZ and LIM domain 5 0.0316113
NDRG1 N-myc downstream regulated 1 0.0314163
UBASH3B ubiquitin associated and SH3 domain containing B 0.0313647
RAB1A RAB1A, member RAS oncogene family 0.0312629
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0307771
FGG fibrinogen gamma chain 0.030756
FGA fibrinogen alpha chain 0.030592
ANKRD11 ankyrin repeat domain 11 0.0304801
KMT2E lysine (K)-specific methyltransferase 2E 0.030123
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0300865
TPI1 triosephosphate isomerase 1 0.0300133
LGALS1 lectin, galactoside-binding, soluble, 1 0.0292907
DDIT4 DNA-damage-inducible transcript 4 0.0292353
RNF145 ring finger protein 145 0.0291065
SIK3 SIK family kinase 3 0.0290165
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0288679
VCL vinculin 0.0287982
MORF4L2 mortality factor 4 like 2 0.0287034
APP amyloid beta (A4) precursor protein 0.0282304
GDNF glial cell derived neurotrophic factor 0.0279177
RSRC2 arginine/serine-rich coiled-coil 2 0.0271391
FLNB filamin B, beta 0.0270537
MSN moesin 0.0267323
KDM5B lysine (K)-specific demethylase 5B 0.0265517
HYOU1 hypoxia up-regulated 1 0.0263392
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0261756
ARF4 ADP-ribosylation factor 4 0.0257638
NEGR1 neuronal growth regulator 1 0.0256072
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0255292
MACF1 microtubule-actin crosslinking factor 1 0.0255226
PRR16 proline rich 16 0.0255164
PCBP2 poly(rC) binding protein 2 0.025453
B2M beta-2-microglobulin 0.0253634
PLS3 plastin 3 0.0252132
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0251486
RPLP0 ribosomal protein, large, P0 0.0247155
LPP LIM domain containing preferred translocation partner in lipoma 0.0247049
HLA-A major histocompatibility complex, class I, A 0.0246985
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0246266

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.259253
MT2A metallothionein 2A -0.160208
TM4SF1 transmembrane 4 L six family member 1 -0.141556
RPS27A ribosomal protein S27a -0.140447
TMSB10 thymosin beta 10 -0.125629
RPL23 ribosomal protein L23 -0.104568
TXNRD1 thioredoxin reductase 1 -0.0963749
PTMA prothymosin, alpha -0.0784717
UBC ubiquitin C -0.0657222
SLC38A2 solute carrier family 38, member 2 -0.0623054
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0571737
RPS12 ribosomal protein S12 -0.0560962
CFLAR CASP8 and FADD-like apoptosis regulator -0.0509627
RPL37A ribosomal protein L37a -0.0476119
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0433937
EEF2 eukaryotic translation elongation factor 2 -0.0393719
RPS29 ribosomal protein S29 -0.0393706
KLF6 Kruppel-like factor 6 -0.0382156
IER3 immediate early response 3 -0.0370809
RPL36 ribosomal protein L36 -0.0368652
RPL26 ribosomal protein L26 -0.0366542
RPS8 ribosomal protein S8 -0.0361914
ACTG1 actin gamma 1 -0.0352747
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0351283
NRG1 neuregulin 1 -0.0342781
RPL4 ribosomal protein L4 -0.0341866
RPL31 ribosomal protein L31 -0.0341766
PM20D1 peptidase M20 domain containing 1 -0.0328294
WWOX WW domain containing oxidoreductase -0.03159
RPS21 ribosomal protein S21 -0.0312868
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.030486
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0300992
MKI67 marker of proliferation Ki-67 -0.0300823
RPS3 ribosomal protein S3 -0.0299627
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.029455
RPL9 ribosomal protein L9 -0.0291706
RPL5 ribosomal protein L5 -0.0284008
RPL37 ribosomal protein L37 -0.0276867
TPT1 tumor protein, translationally-controlled 1 -0.0275375
RPS17 ribosomal protein S17 -0.0272673
AHNAK AHNAK nucleoprotein -0.0269427
AREG amphiregulin -0.0266072
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0262742
NCEH1 neutral cholesterol ester hydrolase 1 -0.0262484
BIRC3 baculoviral IAP repeat containing 3 -0.026113
ATP5F1E ATP synthase F1 subunit epsilon -0.0260396
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0258775
FAF1 Fas (TNFRSF6) associated factor 1 -0.0255582
OSMR oncostatin M receptor -0.0253032
RPS25 ribosomal protein S25 -0.0251741
TBCA tubulin folding cofactor A -0.0249935
RPLP1 ribosomal protein, large, P1 -0.0245275
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0244049
HDAC9 histone deacetylase 9 -0.0240054
RPLP2 ribosomal protein, large, P2 -0.0234923
RPL30 ribosomal protein L30 -0.0232892
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0230972
RPS24 ribosomal protein S24 -0.0229839
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0229568
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0224906
NTN4 netrin 4 -0.0220641
RFWD3 ring finger and WD repeat domain 3 -0.0216324
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0215702
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0213505
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0211066
TOP2A topoisomerase (DNA) II alpha 170kDa -0.021025
EIF5B eukaryotic translation initiation factor 5B -0.0209306
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0208131
TNPO1 transportin 1 -0.0207381
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.02068
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0204758
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0203055
RPL15 ribosomal protein L15 -0.0201008
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.019899
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0195541
RPL36AL ribosomal protein L36a-like -0.0193912
ANKRD12 ankyrin repeat domain 12 -0.0193489
NIPBL Nipped-B homolog (Drosophila) -0.0193266
RPTOR regulatory associated protein of MTOR, complex 1 -0.0193052
PABPN1 poly(A) binding protein, nuclear 1 -0.0190652
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0190028
RPL12 ribosomal protein L12 -0.0185775
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -0.0185213
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.018486
NAV3 neuron navigator 3 -0.0183761
SLC38A1 solute carrier family 38, member 1 -0.0183636
RPL13A ribosomal protein L13a -0.018318
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.01822
VMP1 vacuole membrane protein 1 -0.0181771
SET SET nuclear proto-oncogene -0.0181763
RTN4 reticulon 4 -0.0180779
RPL19 ribosomal protein L19 -0.0180752
RPL18 ribosomal protein L18 -0.0180442
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.017912
KYNU kynureninase -0.0176844
CMIP c-Maf inducing protein -0.0175496
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0175048
DGKD diacylglycerol kinase, delta 130kDa -0.0174596
NAP1L1 nucleosome assembly protein 1-like 1 -0.0174022
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0172965