Omeprazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.114395
NDRG1 N-myc downstream regulated 1 0.106236
DSCAM Down syndrome cell adhesion molecule 0.0984089
NEBL nebulette 0.0877194
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0861663
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.085926
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0829916
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0828308
ERRFI1 ERBB receptor feedback inhibitor 1 0.0754803
ANXA2 annexin A2 0.0744964
MBD5 methyl-CpG binding domain protein 5 0.0739079
NIPBL Nipped-B homolog (Drosophila) 0.0736175
KYNU kynureninase 0.073335
PRKG1 protein kinase, cGMP-dependent, type I 0.0717955
NF1 neurofibromin 1 0.0700916
ANKRD17 ankyrin repeat domain 17 0.0677451
MARCHF7 membrane associated ring-CH-type finger 7 0.0674309
TXNIP thioredoxin interacting protein 0.0635338
LOC102724023 ES1 protein homolog, mitochondrial 0.0625443
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0613422
NPEPPS aminopeptidase puromycin sensitive 0.060685
ENO1 enolase 1, (alpha) 0.0600475
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0596679
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0579618
SQSTM1 sequestosome 1 0.0573993
CEP350 centrosomal protein 350kDa 0.0555927
KDM2A lysine (K)-specific demethylase 2A 0.0550584
CUL3 cullin 3 0.0539333
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.053441
MYOF myoferlin 0.0533221
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0526799
VCL vinculin 0.0519621
ANXA1 annexin A1 0.0512441
AKAP9 A kinase (PRKA) anchor protein 9 0.0500707
PTK2 protein tyrosine kinase 2 0.0493059
ATXN1 ataxin 1 0.0490241
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0488399
MAPK6 mitogen-activated protein kinase 6 0.0485566
USP53 ubiquitin specific peptidase 53 0.0476974
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0462753
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0451977
SEC24D SEC24 family member D 0.0446318
DSG2 desmoglein 2 0.0446041
HMGA2 high mobility group AT-hook 2 0.0443331
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0438534
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0428886
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0428671
XRN1 5'-3' exoribonuclease 1 0.0425921
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0424403
DTNA dystrobrevin, alpha 0.0424212
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0411108
PHF21A PHD finger protein 21A 0.0408047
SP100 SP100 nuclear antigen 0.0404056
NCOR1 nuclear receptor corepressor 1 0.0400794
EXOC4 exocyst complex component 4 0.0400542
AFF4 AF4/FMR2 family, member 4 0.0400421
FAT1 FAT atypical cadherin 1 0.0397651
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0390114
BTBD9 BTB (POZ) domain containing 9 0.0387163
GPBP1 GC-rich promoter binding protein 1 0.038712
SOS1 son of sevenless homolog 1 (Drosophila) 0.0381381
ARB2A ARB2 cotranscriptional regulator A 0.0379861
EP300 E1A binding protein p300 0.0376337
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.037051
RNF213 ring finger protein 213 0.0360969
LOC112694756 uncharaterized LOC112694756 0.0359412
BTG1 B-cell translocation gene 1, anti-proliferative 0.0352379
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0352349
MON2 MON2 homolog (S. cerevisiae) 0.0351054
SRPK2 SRSF protein kinase 2 0.0350932
BZW1 basic leucine zipper and W2 domains 1 0.0349587
RSAD2 radical S-adenosyl methionine domain containing 2 0.0347316
AUTS2 autism susceptibility candidate 2 0.0345138
KIF1B kinesin family member 1B 0.0345122
RPL5 ribosomal protein L5 0.0343833
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0339089
YAP1 Yes-associated protein 1 0.0337615
EPS8 epidermal growth factor receptor pathway substrate 8 0.0335542
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0335048
PERP PERP, TP53 apoptosis effector 0.0334577
WWC1 WW and C2 domain containing 1 0.0334165
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0333336
ANO6 anoctamin 6 0.0333181
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.033218
EFNA5 ephrin-A5 0.0331579
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0330297
RUFY1 RUN and FYVE domain containing 1 0.0327023
STEAP4 STEAP family member 4 0.0325819
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0325808
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0325801
GLG1 golgi glycoprotein 1 0.0324688
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.032449
SIK3 SIK family kinase 3 0.0321487
PLS3 plastin 3 0.0320554
FLNB filamin B, beta 0.0317022
PDLIM5 PDZ and LIM domain 5 0.0313231
ZNF638 zinc finger protein 638 0.0311628
CDK12 cyclin-dependent kinase 12 0.0310192
CTNND1 catenin (cadherin-associated protein), delta 1 0.0306751
PTGES2 prostaglandin E synthase 2 0.030668

decreased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding -0.145949
TRIO trio Rho guanine nucleotide exchange factor -0.109427
PDE4D phosphodiesterase 4D, cAMP-specific -0.0940188
SHB Src homology 2 domain containing adaptor protein B -0.0872375
TPT1 tumor protein, translationally-controlled 1 -0.0802983
EGFR epidermal growth factor receptor -0.0718395
NAMPT nicotinamide phosphoribosyltransferase -0.0686359
RUNX1 runt-related transcription factor 1 -0.0680156
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0655512
CD44 CD44 molecule (Indian blood group) -0.0609648
RNF145 ring finger protein 145 -0.0597873
ADGRB3 adhesion G protein-coupled receptor B3 -0.0588426
BRWD1 bromodomain and WD repeat domain containing 1 -0.0587792
SAMD4A sterile alpha motif domain containing 4A -0.0580942
TXNRD1 thioredoxin reductase 1 -0.0576436
PLAUR plasminogen activator, urokinase receptor -0.0571199
GLS2 glutaminase 2 (liver, mitochondrial) -0.0560671
PTPRM protein tyrosine phosphatase, receptor type, M -0.0560445
FBXO11 F-box protein 11 -0.052887
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0528078
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0523394
TPM4 tropomyosin 4 -0.051372
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0510251
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0495041
LIMCH1 LIM and calponin homology domains 1 -0.0492023
ZNF395 zinc finger protein 395 -0.0480434
HOMER1 homer scaffolding protein 1 -0.0449652
RPS6 ribosomal protein S6 -0.0442616
HIPK2 homeodomain interacting protein kinase 2 -0.0439911
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0439443
STC1 stanniocalcin 1 -0.0436694
RSRC2 arginine/serine-rich coiled-coil 2 -0.0434338
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0424818
LSAMP limbic system-associated membrane protein -0.0423907
TUFT1 tuftelin 1 -0.0421825
AGFG1 ArfGAP with FG repeats 1 -0.0420061
CLINT1 clathrin interactor 1 -0.0415946
MACF1 microtubule-actin crosslinking factor 1 -0.0410191
MXD1 MAX dimerization protein 1 -0.0409311
ESYT2 extended synaptotagmin-like protein 2 -0.0407852
CA12 carbonic anhydrase XII -0.0407658
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0407584
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0407298
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0405852
SOD2 superoxide dismutase 2, mitochondrial -0.0405605
KIF13B kinesin family member 13B -0.0405055
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0404978
ABI3BP ABI family, member 3 (NESH) binding protein -0.0403983
RABGAP1L RAB GTPase activating protein 1-like -0.0398857
ATOSA atos homolog A -0.039636
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0393024
FRMD5 FERM domain containing 5 -0.0389796
VIM vimentin -0.0389551
AK1 adenylate kinase 1 -0.038723
CHD1 chromodomain helicase DNA binding protein 1 -0.0386787
KDM4C lysine (K)-specific demethylase 4C -0.038552
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0385091
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0382552
USP3 ubiquitin specific peptidase 3 -0.037842
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0374941
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0374745
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0373543
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0370887
ANTXR2 anthrax toxin receptor 2 -0.0370326
MYO1E myosin IE -0.0369738
RBM47 RNA binding motif protein 47 -0.0369478
CALU calumenin -0.0367807
SRP54 signal recognition particle 54kDa -0.0367386
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0367162
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0366824
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0364352
VMP1 vacuole membrane protein 1 -0.0362347
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0359242
ARHGAP32 Rho GTPase activating protein 32 -0.0358263
ENO2 enolase 2 (gamma, neuronal) -0.0356727
SPAG9 sperm associated antigen 9 -0.0350435
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0349433
S100A10 S100 calcium binding protein A10 -0.0348844
PCBP2 poly(rC) binding protein 2 -0.0347989
FTH1 ferritin, heavy polypeptide 1 -0.0346857
NEK7 NIMA-related kinase 7 -0.0346235
THOC2 THO complex 2 -0.0343096
PIBF1 progesterone immunomodulatory binding factor 1 -0.0342696
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0342446
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0342223
RNF24 ring finger protein 24 -0.0342042
OSBP oxysterol binding protein -0.0340172
CMIP c-Maf inducing protein -0.0339887
INTS6 integrator complex subunit 6 -0.0339416
MYO10 myosin X -0.033652
CCDC88A coiled-coil domain containing 88A -0.0336433
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0335576
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0331916
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0330108
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0330056
VEGFA vascular endothelial growth factor A -0.0329681
KTN1 kinectin 1 (kinesin receptor) -0.0327671
SBF2 SET binding factor 2 -0.0327507
TMOD3 tropomodulin 3 (ubiquitous) -0.0326006
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0325909