Omeprazole_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.204238
AKAP12 A kinase (PRKA) anchor protein 12 0.189943
RAD51B RAD51 paralog B 0.107109
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.103041
PDE4D phosphodiesterase 4D, cAMP-specific 0.090676
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0837363
THSD4 thrombospondin, type I, domain containing 4 0.0817009
MCL1 myeloid cell leukemia 1 0.0776873
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0767621
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0762959
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0683436
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0669328
GRAMD1B GRAM domain containing 1B 0.0660686
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0649001
TPM3 tropomyosin 3 0.0601152
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0599203
LRPPRC leucine-rich pentatricopeptide repeat containing 0.057738
IGF1R insulin-like growth factor 1 receptor 0.0569548
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0542837
ADAR adenosine deaminase, RNA-specific 0.053846
ERRFI1 ERBB receptor feedback inhibitor 1 0.0534008
CSDE1 cold shock domain containing E1, RNA-binding 0.0527511
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0522725
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0522218
EXOC4 exocyst complex component 4 0.0510905
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0503053
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0491534
TXNRD1 thioredoxin reductase 1 0.0480381
VCL vinculin 0.0474425
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0466091
TRIP12 thyroid hormone receptor interactor 12 0.0465886
TRIO trio Rho guanine nucleotide exchange factor 0.045614
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0452198
EEF2 eukaryotic translation elongation factor 2 0.0435922
AHNAK AHNAK nucleoprotein 0.0415873
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0407736
MACF1 microtubule-actin crosslinking factor 1 0.0406499
XPO1 exportin 1 0.0405852
RIMS2 regulating synaptic membrane exocytosis 2 0.0401663
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0397159
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0395079
MYH9 myosin, heavy chain 9, non-muscle 0.0389267
PRKCE protein kinase C, epsilon 0.0387143
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0377442
BBX bobby sox homolog (Drosophila) 0.037591
CANX calnexin 0.0372369
SMAD3 SMAD family member 3 0.0369758
HMGA2 high mobility group AT-hook 2 0.0357692
PARP14 poly (ADP-ribose) polymerase family, member 14 0.034424
LDHA lactate dehydrogenase A 0.0340723
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0339841
ELL2 elongation factor, RNA polymerase II, 2 0.0337299
MSH6 mutS homolog 6 0.0337208
TAS2R14 taste receptor, type 2, member 14 0.0334494
ZBTB20 zinc finger and BTB domain containing 20 0.0332758
YBX3 Y box binding protein 3 0.0330908
FMNL2 formin-like 2 0.0328851
RICTOR RPTOR independent companion of MTOR, complex 2 0.0327926
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0326513
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326359
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.032285
PCBP2 poly(rC) binding protein 2 0.0322548
RRM2 ribonucleotide reductase M2 0.0318805
USP34 ubiquitin specific peptidase 34 0.0317804
TBC1D5 TBC1 domain family, member 5 0.0317553
YAP1 Yes-associated protein 1 0.0316835
ZFAND3 zinc finger, AN1-type domain 3 0.0315165
PDE10A phosphodiesterase 10A 0.0314149
ANO6 anoctamin 6 0.0311832
BZW1 basic leucine zipper and W2 domains 1 0.0308245
PGK1 phosphoglycerate kinase 1 0.0306991
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0306913
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0304811
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0302359
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0300166
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0297532
PRELID2 PRELI domain containing 2 0.0296279
EXT1 exostosin glycosyltransferase 1 0.0292445
SFPQ splicing factor proline/glutamine-rich 0.0292098
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.029187
MED13L mediator complex subunit 13-like 0.0291551
CEP250 centrosomal protein 250kDa 0.0291431
NCAPG2 non-SMC condensin II complex, subunit G2 0.0291078
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0290656
MKI67 marker of proliferation Ki-67 0.0286538
CLTC clathrin, heavy chain (Hc) 0.0285945
NF1 neurofibromin 1 0.0285548
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0284775
TLN1 talin 1 0.0284411
CHD4 chromodomain helicase DNA binding protein 4 0.0283916
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0283539
NCAPD2 non-SMC condensin I complex, subunit D2 0.0281643
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0281239
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0280162
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0279493
DST dystonin 0.0278754
OSMR oncostatin M receptor 0.0277555
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0274812
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0272414
PHF3 PHD finger protein 3 0.0270617

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103823
TMSB10 thymosin beta 10 -0.0888963
RPL35A ribosomal protein L35a -0.0611642
RPL37A ribosomal protein L37a -0.053891
RPS8 ribosomal protein S8 -0.0533193
RPLP1 ribosomal protein, large, P1 -0.0444241
RPS19 ribosomal protein S19 -0.0444015
MT2A metallothionein 2A -0.0410044
RPL37 ribosomal protein L37 -0.0390517
RPS3 ribosomal protein S3 -0.0380774
RPL26 ribosomal protein L26 -0.0380205
PTMA prothymosin, alpha -0.0379048
RPL36 ribosomal protein L36 -0.0375245
RPS12 ribosomal protein S12 -0.0360324
TPT1 tumor protein, translationally-controlled 1 -0.0351748
RPLP2 ribosomal protein, large, P2 -0.0349442
RPL34 ribosomal protein L34 -0.0315167
RPS27 ribosomal protein S27 -0.0312593
HLA-B major histocompatibility complex, class I, B -0.0311003
RPL23 ribosomal protein L23 -0.0303174
RPL5 ribosomal protein L5 -0.0298851
RPL9 ribosomal protein L9 -0.0291074
RPS21 ribosomal protein S21 -0.0274746
RPS29 ribosomal protein S29 -0.0265837
FTL ferritin, light polypeptide -0.026242
FTH1 ferritin, heavy polypeptide 1 -0.0255133
RPL31 ribosomal protein L31 -0.0251734
RPS6 ribosomal protein S6 -0.0244249
RPS10 ribosomal protein S10 -0.0236606
RPL35 ribosomal protein L35 -0.0235591
RPS27A ribosomal protein S27a -0.0234767
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0229845
EIF5B eukaryotic translation initiation factor 5B -0.0228235
RPL12 ribosomal protein L12 -0.0227662
RPS15 ribosomal protein S15 -0.022749
RPL38 ribosomal protein L38 -0.0224737
RPL28 ribosomal protein L28 -0.0217709
SEPTIN7 septin 7 -0.0217527
RPL36A ribosomal protein L36a -0.0216853
WSB1 WD repeat and SOCS box containing 1 -0.0216441
RPS25 ribosomal protein S25 -0.0214483
EGR1 early growth response 1 -0.0212836
RPL8 ribosomal protein L8 -0.021201
RPL27 ribosomal protein L27 -0.0202191
RPS17 ribosomal protein S17 -0.0202189
RPL19 ribosomal protein L19 -0.0201131
LOC102724023 ES1 protein homolog, mitochondrial -0.0199976
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0191864
PFN1 profilin 1 -0.0191654
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.018295
RPL7A ribosomal protein L7a -0.0180698
ATP5F1E ATP synthase F1 subunit epsilon -0.0175592
RPL30 ribosomal protein L30 -0.0175438
AKAP9 A kinase (PRKA) anchor protein 9 -0.0172281
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0171258
RPS20 ribosomal protein S20 -0.0168317
ANKRD12 ankyrin repeat domain 12 -0.0168026
RPL32 ribosomal protein L32 -0.016288
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0155743
RPS13 ribosomal protein S13 -0.0154321
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0153992
S100A6 S100 calcium binding protein A6 -0.0151843
RPL18 ribosomal protein L18 -0.0147618
HLA-A major histocompatibility complex, class I, A -0.0145708
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0144168
RPS14 ribosomal protein S14 -0.0142042
SRSF11 serine/arginine-rich splicing factor 11 -0.0141062
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0137228
RPS16 ribosomal protein S16 -0.0133022
IER3 immediate early response 3 -0.0131211
RPS24 ribosomal protein S24 -0.0127858
GOLGA4 golgin A4 -0.0126955
IKBIP IKBKB interacting protein -0.0125146
IGF2 insulin-like growth factor 2 -0.0124536
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0122296
RPL39 ribosomal protein L39 -0.0121604
RACK1 receptor for activated C kinase 1 -0.0120586
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0120258
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0119499
RPS23 ribosomal protein S23 -0.0118696
S100A11 S100 calcium binding protein A11 -0.0115512
ROMO1 reactive oxygen species modulator 1 -0.0114854
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0114653
MT1X metallothionein 1X -0.0113933
MYL12B myosin, light chain 12B, regulatory -0.0113153
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0112856
SEC61G Sec61 gamma subunit -0.0108406
RPS26 ribosomal protein S26 -0.0107888
SEC24A SEC24 family member A -0.0107539
IFITM3 interferon induced transmembrane protein 3 -0.0106901
RBM25 RNA binding motif protein 25 -0.010572
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.0104729
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0103582
RAB7A RAB7A, member RAS oncogene family -0.0102607
DCAF7 DDB1 and CUL4 associated factor 7 -0.00996092
RPL13A ribosomal protein L13a -0.00995968
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0098962
RPS4X ribosomal protein S4, X-linked -0.00972015
RPS2 ribosomal protein S2 -0.00963054
ATP5MG ATP synthase membrane subunit g -0.00953479