Omeprazole_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 0.113024
FN1 fibronectin 1 0.106572
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100656
FNDC3B fibronectin type III domain containing 3B 0.0978307
CANX calnexin 0.0778873
FAM13A family with sequence similarity 13, member A 0.0761498
LPP LIM domain containing preferred translocation partner in lipoma 0.0721388
DSPP dentin sialophosphoprotein 0.0625297
TMSB4X thymosin beta 4, X-linked 0.0616044
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0615404
BZW1 basic leucine zipper and W2 domains 1 0.0599531
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0562663
IGFBP3 insulin-like growth factor binding protein 3 0.053607
LIMCH1 LIM and calponin homology domains 1 0.0525234
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.049665
LMO7 LIM domain 7 0.0491586
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0490289
TRIO trio Rho guanine nucleotide exchange factor 0.0487239
MYH9 myosin, heavy chain 9, non-muscle 0.0480344
MYO6 myosin VI 0.0476222
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0470022
PTMA prothymosin, alpha 0.0467495
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.044865
FBXO32 F-box protein 32 0.0441995
AHNAK AHNAK nucleoprotein 0.0429878
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0414315
KDM5B lysine (K)-specific demethylase 5B 0.0409244
PGK1 phosphoglycerate kinase 1 0.040897
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0407105
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0399824
TSC22D2 TSC22 domain family, member 2 0.039665
COPA coatomer protein complex, subunit alpha 0.0390562
IQGAP1 IQ motif containing GTPase activating protein 1 0.0389095
KMT2E lysine (K)-specific methyltransferase 2E 0.0388972
ASPH aspartate beta-hydroxylase 0.0386241
FXR1 fragile X mental retardation, autosomal homolog 1 0.0381614
PTK2 protein tyrosine kinase 2 0.0372914
RAI14 retinoic acid induced 14 0.0369318
CD2AP CD2-associated protein 0.0365116
NPEPPS aminopeptidase puromycin sensitive 0.0354727
GPBP1 GC-rich promoter binding protein 1 0.034779
KDM3A lysine (K)-specific demethylase 3A 0.034281
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0342567
TPM3 tropomyosin 3 0.0339453
SPTBN1 spectrin, beta, non-erythrocytic 1 0.033606
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0334656
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0334354
PDLIM5 PDZ and LIM domain 5 0.0332587
MARCHF6 membrane associated ring-CH-type finger 6 0.0329215
CD109 CD109 molecule 0.0329057
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0327652
SEC23A Sec23 homolog A (S. cerevisiae) 0.0322759
TOP1 topoisomerase (DNA) I 0.0320071
F3 coagulation factor III (thromboplastin, tissue factor) 0.0314212
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0308277
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0308187
MSI2 musashi RNA-binding protein 2 0.0303888
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0299981
MACF1 microtubule-actin crosslinking factor 1 0.0298159
PLEC plectin 0.0297845
ANXA2 annexin A2 0.0297342
CCND1 cyclin D1 0.0295553
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0289556
HELZ helicase with zinc finger 0.0277169
SH3KBP1 SH3-domain kinase binding protein 1 0.0269658
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0268178
SQSTM1 sequestosome 1 0.0266257
ZFAND3 zinc finger, AN1-type domain 3 0.0263117
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0262507
WSB1 WD repeat and SOCS box containing 1 0.0258251
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0253454
KRT18 keratin 18, type I 0.0252161
LAMC2 laminin, gamma 2 0.0251298
FLNB filamin B, beta 0.0248855
STAG2 stromal antigen 2 0.0247313
IRF6 interferon regulatory factor 6 0.0247057
TPM4 tropomyosin 4 0.0245982
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0243792
KMT2C lysine (K)-specific methyltransferase 2C 0.0242868
IFI16 interferon, gamma-inducible protein 16 0.0242825
SAMD4A sterile alpha motif domain containing 4A 0.0242612
FAM168A family with sequence similarity 168, member A 0.0241805
MCU mitochondrial calcium uniporter 0.0240989
ZNF292 zinc finger protein 292 0.0240557
CTNND1 catenin (cadherin-associated protein), delta 1 0.0238056
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0237433
MX1 MX dynamin-like GTPase 1 0.0232746
ACBD3 acyl-CoA binding domain containing 3 0.0231946
RBM39 RNA binding motif protein 39 0.0230073
CLTC clathrin, heavy chain (Hc) 0.0229959
PICALM phosphatidylinositol binding clathrin assembly protein 0.022971
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0228902
RNF213 ring finger protein 213 0.0228202
AFF4 AF4/FMR2 family, member 4 0.0228169
SSBP2 single-stranded DNA binding protein 2 0.022622
RAB1A RAB1A, member RAS oncogene family 0.0225252
AHNAK2 AHNAK nucleoprotein 2 0.0222678
UBA6 ubiquitin-like modifier activating enzyme 6 0.0222105
CDC73 cell division cycle 73 0.0220942
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220702

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.379968
FTL ferritin, light polypeptide -0.198184
NDRG1 N-myc downstream regulated 1 -0.159253
MT2A metallothionein 2A -0.129038
TMSB10 thymosin beta 10 -0.124251
HMGA1 high mobility group AT-hook 1 -0.0958124
ACTG1 actin gamma 1 -0.0904963
RPS19 ribosomal protein S19 -0.0834719
RPLP1 ribosomal protein, large, P1 -0.0782466
RPL35A ribosomal protein L35a -0.0668012
POTEF POTE ankyrin domain family, member F -0.0658183
RPS23 ribosomal protein S23 -0.0649367
RPLP2 ribosomal protein, large, P2 -0.064762
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0646527
RPL34 ribosomal protein L34 -0.0641645
RPL8 ribosomal protein L8 -0.0552609
RPS29 ribosomal protein S29 -0.0506554
RPS13 ribosomal protein S13 -0.0504403
RPL32 ribosomal protein L32 -0.0475535
RPS8 ribosomal protein S8 -0.0448549
RPL9 ribosomal protein L9 -0.0433751
TUBB4B tubulin, beta 4B class IVb -0.0415529
RPL23 ribosomal protein L23 -0.0403779
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391607
RPL28 ribosomal protein L28 -0.0386561
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0379952
RPS6 ribosomal protein S6 -0.0374573
EIF1 eukaryotic translation initiation factor 1 -0.036735
RPS21 ribosomal protein S21 -0.0365108
RPS14 ribosomal protein S14 -0.0351273
TPT1 tumor protein, translationally-controlled 1 -0.0351169
LOC112694756 uncharaterized LOC112694756 -0.0349681
RPL37A ribosomal protein L37a -0.034564
RPL30 ribosomal protein L30 -0.034096
RPS5 ribosomal protein S5 -0.0335624
S100A9 S100 calcium binding protein A9 -0.032971
RPS27 ribosomal protein S27 -0.0326502
RPL31 ribosomal protein L31 -0.0325924
RPL19 ribosomal protein L19 -0.0324832
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0320927
RPL12 ribosomal protein L12 -0.0314387
CLDN4 claudin 4 -0.03094
IFI27 interferon, alpha-inducible protein 27 -0.0308296
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0307751
RPL36 ribosomal protein L36 -0.0307511
RPL5 ribosomal protein L5 -0.0305504
S100A6 S100 calcium binding protein A6 -0.0300607
RPS25 ribosomal protein S25 -0.0291408
RPL37 ribosomal protein L37 -0.0288865
CCNI cyclin I -0.0282579
RPS15 ribosomal protein S15 -0.0274833
RPS10 ribosomal protein S10 -0.0272306
S100A10 S100 calcium binding protein A10 -0.0272201
RPS3 ribosomal protein S3 -0.0271309
CDCP1 CUB domain containing protein 1 -0.0270941
TACSTD2 tumor-associated calcium signal transducer 2 -0.0267189
UPP1 uridine phosphorylase 1 -0.0258638
BRD2 bromodomain containing 2 -0.0257617
RPS16 ribosomal protein S16 -0.0254479
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0252317
SDC4 syndecan 4 -0.0252055
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0251317
RPS11 ribosomal protein S11 -0.0245869
SMC4 structural maintenance of chromosomes 4 -0.0242564
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.02399
RPL35 ribosomal protein L35 -0.0239537
FTH1 ferritin, heavy polypeptide 1 -0.0234364
RPLP0 ribosomal protein, large, P0 -0.0233893
RACK1 receptor for activated C kinase 1 -0.0233648
TAPBP TAP binding protein (tapasin) -0.0230631
ANKRD37 ankyrin repeat domain 37 -0.0228805
MUC1 mucin 1, cell surface associated -0.022336
ATP5F1E ATP synthase F1 subunit epsilon -0.0223102
ISG15 ISG15 ubiquitin-like modifier -0.0222579
RPL38 ribosomal protein L38 -0.0220806
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0218943
COX7C cytochrome c oxidase subunit VIIc -0.0216474
TXNRD1 thioredoxin reductase 1 -0.0216396
TUBA1C tubulin, alpha 1c -0.0216214
SLC38A1 solute carrier family 38, member 1 -0.0216129
RPL27 ribosomal protein L27 -0.0215912
RPS12 ribosomal protein S12 -0.0214748
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0212858
RPL27A ribosomal protein L27a -0.0205905
LOC102724023 ES1 protein homolog, mitochondrial -0.020433
GOLGA4 golgin A4 -0.020342
RPL15 ribosomal protein L15 -0.0202051
GPX4 glutathione peroxidase 4 -0.0198102
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.019733
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0196788
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0196386
TXNIP thioredoxin interacting protein -0.0196289
EGR1 early growth response 1 -0.0195072
OSMR oncostatin M receptor -0.0192911
RPL7A ribosomal protein L7a -0.0188477
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0187226
NPC2 Niemann-Pick disease, type C2 -0.0186302
AREG amphiregulin -0.018621
HLA-B major histocompatibility complex, class I, B -0.0185621
EFNA5 ephrin-A5 -0.0183038