Omeprazole_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.189705
ASPH aspartate beta-hydroxylase 0.153395
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.142992
EFNA5 ephrin-A5 0.125785
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.119129
NAMPT nicotinamide phosphoribosyltransferase 0.115349
MYOF myoferlin 0.11049
CANX calnexin 0.0815175
CXCL8 chemokine (C-X-C motif) ligand 8 0.0812606
TXNRD1 thioredoxin reductase 1 0.0798494
ELL2 elongation factor, RNA polymerase II, 2 0.0783328
PM20D1 peptidase M20 domain containing 1 0.0759232
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0741267
TRIO trio Rho guanine nucleotide exchange factor 0.0728575
IGFBP3 insulin-like growth factor binding protein 3 0.0716798
LIMCH1 LIM and calponin homology domains 1 0.07054
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0683161
NEK7 NIMA-related kinase 7 0.0666026
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0651438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.065063
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0573883
GDA guanine deaminase 0.0561761
FNDC3B fibronectin type III domain containing 3B 0.0556482
NRCAM neuronal cell adhesion molecule 0.0532711
PSD3 pleckstrin and Sec7 domain containing 3 0.0503155
TGFBR1 transforming growth factor, beta receptor 1 0.0494571
KYNU kynureninase 0.0480078
BZW1 basic leucine zipper and W2 domains 1 0.0479193
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0479022
PGK1 phosphoglycerate kinase 1 0.0474856
ERRFI1 ERBB receptor feedback inhibitor 1 0.0474414
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.046363
MCL1 myeloid cell leukemia 1 0.04633
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0457222
LDHA lactate dehydrogenase A 0.0441753
COL5A2 collagen, type V, alpha 2 0.0436981
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0427961
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0425534
PCBP3 poly(rC) binding protein 3 0.0404549
CTSC cathepsin C 0.040304
CENPF centromere protein F, 350/400kDa 0.0399913
SPAG9 sperm associated antigen 9 0.0393655
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0392416
ESYT2 extended synaptotagmin-like protein 2 0.0391781
TMX4 thioredoxin-related transmembrane protein 4 0.0389386
SAMD4A sterile alpha motif domain containing 4A 0.0384705
COL8A1 collagen, type VIII, alpha 1 0.038246
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0380919
ANXA1 annexin A1 0.0378533
LAMA1 laminin, alpha 1 0.0369631
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0368766
BIRC6 baculoviral IAP repeat containing 6 0.0368028
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0364986
OGA O-GlcNAcase 0.0364915
DST dystonin 0.0361872
EZR ezrin 0.0360241
PDIA3 protein disulfide isomerase family A, member 3 0.0357155
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0340315
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0325792
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0322246
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0321442
SOD2 superoxide dismutase 2, mitochondrial 0.03191
FAM13A family with sequence similarity 13, member A 0.0316171
USP9X ubiquitin specific peptidase 9, X-linked 0.0310039
ZEB2 zinc finger E-box binding homeobox 2 0.0308647
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0301778
DGKD diacylglycerol kinase, delta 130kDa 0.0297549
CD109 CD109 molecule 0.0295276
PCBP2 poly(rC) binding protein 2 0.0287549
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0287511
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0285615
ITPRID2 ITPR interacting domain containing 2 0.0281483
HELZ helicase with zinc finger 0.028033
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0278676
APLP2 amyloid beta (A4) precursor-like protein 2 0.0271326
ANXA2 annexin A2 0.0270554
RTN4 reticulon 4 0.0270084
COPA coatomer protein complex, subunit alpha 0.0268144
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.026692
ENO1 enolase 1, (alpha) 0.0264244
PDIA6 protein disulfide isomerase family A, member 6 0.0259363
NUP58 nucleoporin 58 0.0257148
BRWD3 bromodomain and WD repeat domain containing 3 0.0256054
NCOA7 nuclear receptor coactivator 7 0.0250711
MKI67 marker of proliferation Ki-67 0.025014
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0246952
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0246619
SUCO SUN domain containing ossification factor 0.0246451
TFPI2 tissue factor pathway inhibitor 2 0.0244688
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0243528
CUL4B cullin 4B 0.0242186
NBAS neuroblastoma amplified sequence 0.0241161
GRAMD1B GRAM domain containing 1B 0.024048
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0240016
NPAS2 neuronal PAS domain protein 2 0.0237067
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0234809
LMAN1 lectin, mannose-binding, 1 0.0234646
FLNB filamin B, beta 0.023183
PTGR1 prostaglandin reductase 1 0.0225254
ATP13A3 ATPase type 13A3 0.0225234

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.153781
TMSB10 thymosin beta 10 -0.149099
RPS6 ribosomal protein S6 -0.125791
VIM vimentin -0.118482
TPT1 tumor protein, translationally-controlled 1 -0.105382
RPLP1 ribosomal protein, large, P1 -0.104585
RPL37A ribosomal protein L37a -0.0923321
RPS19 ribosomal protein S19 -0.0921056
RPL26 ribosomal protein L26 -0.0886932
RPS12 ribosomal protein S12 -0.0870498
FTL ferritin, light polypeptide -0.0856975
PTMA prothymosin, alpha -0.085497
RPS8 ribosomal protein S8 -0.084399
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0820748
RPL31 ribosomal protein L31 -0.0803487
RPL35A ribosomal protein L35a -0.0784097
PDE4D phosphodiesterase 4D, cAMP-specific -0.0737682
CDH13 cadherin 13 -0.0706879
RPL12 ribosomal protein L12 -0.0676912
RPL23 ribosomal protein L23 -0.0634874
RPS3 ribosomal protein S3 -0.0616309
RPS24 ribosomal protein S24 -0.0593843
RPS27 ribosomal protein S27 -0.0587418
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0586817
RPLP2 ribosomal protein, large, P2 -0.0584203
RPL19 ribosomal protein L19 -0.0579195
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0577264
RPL36 ribosomal protein L36 -0.0568938
RPL9 ribosomal protein L9 -0.0564168
RPS23 ribosomal protein S23 -0.0561968
RPL36A ribosomal protein L36a -0.0558191
RPL34 ribosomal protein L34 -0.0544903
RPS14 ribosomal protein S14 -0.0526282
RPL37 ribosomal protein L37 -0.0522883
RPS29 ribosomal protein S29 -0.0508333
RPL7A ribosomal protein L7a -0.047786
RPS27A ribosomal protein S27a -0.0477063
RPS17 ribosomal protein S17 -0.046671
RPS25 ribosomal protein S25 -0.0466522
RPL35 ribosomal protein L35 -0.0462851
RPS16 ribosomal protein S16 -0.0461279
NALF1 NALCN channel auxiliary factor 1 -0.0429793
RPS21 ribosomal protein S21 -0.0401054
SOX4 SRY (sex determining region Y)-box 4 -0.0396513
RPL11 ribosomal protein L11 -0.0383229
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0380548
HLA-B major histocompatibility complex, class I, B -0.0358491
RPL5 ribosomal protein L5 -0.0357484
RPS13 ribosomal protein S13 -0.0344772
RPL18 ribosomal protein L18 -0.0343159
RPL38 ribosomal protein L38 -0.0340442
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0339498
RPL27 ribosomal protein L27 -0.0337523
TTC28 tetratricopeptide repeat domain 28 -0.0332991
PTPRM protein tyrosine phosphatase, receptor type, M -0.0331743
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0330415
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0328602
ADGRD1 adhesion G protein-coupled receptor D1 -0.0327957
ASTN2 astrotactin 2 -0.0321731
RACK1 receptor for activated C kinase 1 -0.031122
RPL28 ribosomal protein L28 -0.0310642
MAML3 mastermind-like 3 (Drosophila) -0.0308589
WARS1 tryptophanyl-tRNA synthetase 1 -0.0305303
RPS4X ribosomal protein S4, X-linked -0.0304063
RPLP0 ribosomal protein, large, P0 -0.0302589
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0300672
RPL32 ribosomal protein L32 -0.0293541
S100A6 S100 calcium binding protein A6 -0.0292115
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0291794
AUTS2 autism susceptibility candidate 2 -0.0288431
LSAMP limbic system-associated membrane protein -0.0284501
P3H2 prolyl 3-hydroxylase 2 -0.0284341
RPS5 ribosomal protein S5 -0.0275963
RPS11 ribosomal protein S11 -0.0269639
TENM3 teneurin transmembrane protein 3 -0.0268929
RPL13A ribosomal protein L13a -0.025985
RPS10 ribosomal protein S10 -0.0251032
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0246959
MT2A metallothionein 2A -0.0239928
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0239629
RPL30 ribosomal protein L30 -0.0238542
CUX1 cut-like homeobox 1 -0.023817
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0230752
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0229717
ACTG1 actin gamma 1 -0.0228651
RPL27A ribosomal protein L27a -0.0226299
ATP5F1E ATP synthase F1 subunit epsilon -0.0224751
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0218355
RPS28 ribosomal protein S28 -0.0218098
RAD51B RAD51 paralog B -0.0214072
SVIL supervillin -0.0213301
RANBP17 RAN binding protein 17 -0.0213156
PCDH9 protocadherin 9 -0.0212964
PRKN parkin RBR E3 ubiquitin protein ligase -0.0212198
ISG15 ISG15 ubiquitin-like modifier -0.0208179
MGST1 microsomal glutathione S-transferase 1 -0.0205866
RPL8 ribosomal protein L8 -0.0204882
SOX6 SRY (sex determining region Y)-box 6 -0.0204036
HLA-A major histocompatibility complex, class I, A -0.0201076
RPS15 ribosomal protein S15 -0.0199993