Omeprazole_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.310127
FN1 fibronectin 1 0.245856
FRMD4A FERM domain containing 4A 0.120704
MYH9 myosin, heavy chain 9, non-muscle 0.116249
PDE10A phosphodiesterase 10A 0.0995995
CADM1 cell adhesion molecule 1 0.0913909
COL6A3 collagen, type VI, alpha 3 0.0913139
VCAN versican 0.0848088
DST dystonin 0.083634
FNDC3B fibronectin type III domain containing 3B 0.0815717
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0777327
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0743471
PGK1 phosphoglycerate kinase 1 0.0729206
SFTPA2 surfactant protein A2 0.0635739
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0629071
MYOF myoferlin 0.0623551
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0619639
ELL2 elongation factor, RNA polymerase II, 2 0.0596242
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0591477
TRIO trio Rho guanine nucleotide exchange factor 0.0581478
IGFBP3 insulin-like growth factor binding protein 3 0.058111
ADM adrenomedullin 0.0554964
CANX calnexin 0.0544597
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0536486
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0534021
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0524811
ZMYND8 zinc finger, MYND-type containing 8 0.0523853
AKAP12 A kinase (PRKA) anchor protein 12 0.0496975
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0493191
ZNF292 zinc finger protein 292 0.0491229
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0490401
NAMPT nicotinamide phosphoribosyltransferase 0.0473767
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0470344
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0463395
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.044006
TNS3 tensin 3 0.0431619
LDHA lactate dehydrogenase A 0.0424327
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0416417
CLIC4 chloride intracellular channel 4 0.0415998
HLA-E major histocompatibility complex, class I, E 0.0415634
VIM vimentin 0.0407468
PLIN2 perilipin 2 0.0393939
VCL vinculin 0.0386128
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0384175
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0378255
SQSTM1 sequestosome 1 0.0376131
UGCG UDP-glucose ceramide glucosyltransferase 0.0376016
KDM3A lysine (K)-specific demethylase 3A 0.0374574
APLP2 amyloid beta (A4) precursor-like protein 2 0.037227
RIGI RNA sensor RIG-I 0.0369808
PHF21A PHD finger protein 21A 0.0365794
MXI1 MAX interactor 1, dimerization protein 0.0362563
AHNAK AHNAK nucleoprotein 0.035502
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0354081
SPAG9 sperm associated antigen 9 0.0346486
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0336039
STAG2 stromal antigen 2 0.033424
ATP13A3 ATPase type 13A3 0.0329229
RNF213 ring finger protein 213 0.0328287
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0326218
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0316653
OPTN optineurin 0.0312964
QKI QKI, KH domain containing, RNA binding 0.031265
RAI14 retinoic acid induced 14 0.0311864
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0311087
LAMP2 lysosomal-associated membrane protein 2 0.0307829
AFF4 AF4/FMR2 family, member 4 0.0304751
OGA O-GlcNAcase 0.030147
RTN4 reticulon 4 0.0301248
ARRDC3 arrestin domain containing 3 0.0299514
ENO1 enolase 1, (alpha) 0.0296398
RND3 Rho family GTPase 3 0.029635
WDFY1 WD repeat and FYVE domain containing 1 0.0296252
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0296028
RBM39 RNA binding motif protein 39 0.0294188
KIF13A kinesin family member 13A 0.0291606
MSN moesin 0.0290171
JMJD1C jumonji domain containing 1C 0.0289219
DIAPH2 diaphanous-related formin 2 0.0288211
LRRC7 leucine rich repeat containing 7 0.0287651
TNIP1 TNFAIP3 interacting protein 1 0.0287396
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0286089
APP amyloid beta (A4) precursor protein 0.0285445
ICAM1 intercellular adhesion molecule 1 0.0283727
C3 complement component 3 0.0277722
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0276853
JUN jun proto-oncogene 0.027595
ANXA2 annexin A2 0.0274962
EXT1 exostosin glycosyltransferase 1 0.0274207
ARF4 ADP-ribosylation factor 4 0.0273474
RB1CC1 RB1-inducible coiled-coil 1 0.0271989
VEGFA vascular endothelial growth factor A 0.0270559
MMP12 matrix metallopeptidase 12 0.0268672
MX1 MX dynamin-like GTPase 1 0.0266632
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0265766
USP9X ubiquitin specific peptidase 9, X-linked 0.0263166
NDRG1 N-myc downstream regulated 1 0.0260964
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0260054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0259431
CTSB cathepsin B 0.0258895

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0913241
TMSB10 thymosin beta 10 -0.0797423
RPS6 ribosomal protein S6 -0.0696612
RPS12 ribosomal protein S12 -0.0628175
FTL ferritin, light polypeptide -0.0611189
RPS3 ribosomal protein S3 -0.0569019
RPL23 ribosomal protein L23 -0.0515128
RPS8 ribosomal protein S8 -0.0514735
RPLP2 ribosomal protein, large, P2 -0.0509406
RPLP1 ribosomal protein, large, P1 -0.0506404
RPL12 ribosomal protein L12 -0.0451525
RPL37A ribosomal protein L37a -0.0448363
RPL26 ribosomal protein L26 -0.0443333
RPS19 ribosomal protein S19 -0.0434013
RPL9 ribosomal protein L9 -0.0416086
TPT1 tumor protein, translationally-controlled 1 -0.0415466
RPL35A ribosomal protein L35a -0.0410028
RPL36 ribosomal protein L36 -0.0380791
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0365383
RPS24 ribosomal protein S24 -0.036105
RPL19 ribosomal protein L19 -0.035351
RPS4X ribosomal protein S4, X-linked -0.0341143
RPL5 ribosomal protein L5 -0.0331068
RPL7A ribosomal protein L7a -0.0317226
RPS25 ribosomal protein S25 -0.0299964
RPL35 ribosomal protein L35 -0.0292437
RPL11 ribosomal protein L11 -0.0289934
HLA-B major histocompatibility complex, class I, B -0.028389
RPS14 ribosomal protein S14 -0.0276833
RPL28 ribosomal protein L28 -0.0256677
RPL36A ribosomal protein L36a -0.0251424
RPS10 ribosomal protein S10 -0.0249386
RPS16 ribosomal protein S16 -0.0247042
RPL31 ribosomal protein L31 -0.0243412
RPS17 ribosomal protein S17 -0.0243236
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0242961
RPS27A ribosomal protein S27a -0.0241301
RPL7 ribosomal protein L7 -0.0237552
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0236868
RPL27 ribosomal protein L27 -0.0232217
RPL32 ribosomal protein L32 -0.0227834
ACTG1 actin gamma 1 -0.0225598
RPS29 ribosomal protein S29 -0.0221742
RACK1 receptor for activated C kinase 1 -0.0212916
RPS13 ribosomal protein S13 -0.0210841
RPL37 ribosomal protein L37 -0.0206077
HMGA2 high mobility group AT-hook 2 -0.0205688
RPL18 ribosomal protein L18 -0.0205538
RPS23 ribosomal protein S23 -0.0200837
RPL27A ribosomal protein L27a -0.0196681
RPS5 ribosomal protein S5 -0.0183295
RPS21 ribosomal protein S21 -0.0182407
RPL34 ribosomal protein L34 -0.0177114
RPL30 ribosomal protein L30 -0.0176234
RPS20 ribosomal protein S20 -0.01753
RPS27 ribosomal protein S27 -0.0174719
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.017015
ATP5F1E ATP synthase F1 subunit epsilon -0.0168194
RPS2 ribosomal protein S2 -0.0163123
RPL10A ribosomal protein L10a -0.0162253
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0162161
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0161976
RPLP0 ribosomal protein, large, P0 -0.0158034
INTS6 integrator complex subunit 6 -0.0156303
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0154601
RPS15 ribosomal protein S15 -0.0149911
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0148492
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0147438
PNISR PNN-interacting serine/arginine-rich protein -0.0147387
PFN1 profilin 1 -0.0146207
RPL21 ribosomal protein L21 -0.0135751
RPL13A ribosomal protein L13a -0.0135523
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0132332
UBB ubiquitin B -0.0129611
PTMA prothymosin, alpha -0.0129533
RPL15 ribosomal protein L15 -0.0128447
RPL38 ribosomal protein L38 -0.0127454
RPL8 ribosomal protein L8 -0.0123291
S100A9 S100 calcium binding protein A9 -0.0122259
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.012154
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0119184
RPL39 ribosomal protein L39 -0.0119044
IFITM3 interferon induced transmembrane protein 3 -0.0117724
RPS11 ribosomal protein S11 -0.0116425
POTEF POTE ankyrin domain family, member F -0.0116262
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.011607
HMGB1 high mobility group box 1 -0.0111785
ASTN2 astrotactin 2 -0.0111479
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0109429
RPL23A ribosomal protein L23a -0.010849
HMGA1 high mobility group AT-hook 1 -0.0105978
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0104547
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0103057
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.01023
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0101069
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.00977227
EIF5B eukaryotic translation initiation factor 5B -0.00966911
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.00955796
GPX4 glutathione peroxidase 4 -0.0092344
MT1X metallothionein 1X -0.00922195