Omeprazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.146667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0841232
CD44 CD44 molecule (Indian blood group) 0.0670452
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0635136
MACF1 microtubule-actin crosslinking factor 1 0.0623727
AHNAK AHNAK nucleoprotein 0.0498436
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0490902
DST dystonin 0.0487412
TXNRD1 thioredoxin reductase 1 0.0480859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0479734
VIM vimentin 0.047843
FNDC3B fibronectin type III domain containing 3B 0.0458187
LOC112694756 uncharaterized LOC112694756 0.0456272
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0452588
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0428757
ZNF292 zinc finger protein 292 0.0422661
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0421719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0417896
CDCP1 CUB domain containing protein 1 0.041134
CENPF centromere protein F, 350/400kDa 0.0402709
KIF5B kinesin family member 5B 0.0400994
AKAP13 A kinase (PRKA) anchor protein 13 0.0385268
CLTC clathrin, heavy chain (Hc) 0.0384586
DPYD dihydropyrimidine dehydrogenase 0.0377327
SMYD3 SET and MYND domain containing 3 0.036592
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0362098
ELL2 elongation factor, RNA polymerase II, 2 0.0359515
MBNL1 muscleblind-like splicing regulator 1 0.0351277
SET SET nuclear proto-oncogene 0.0340097
ZBTB20 zinc finger and BTB domain containing 20 0.033843
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0332226
IQGAP1 IQ motif containing GTPase activating protein 1 0.0331523
AKAP9 A kinase (PRKA) anchor protein 9 0.0329429
ATM ATM serine/threonine kinase 0.0326075
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0324938
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0316527
CSNK1A1 casein kinase 1, alpha 1 0.031172
PHF3 PHD finger protein 3 0.0310103
SMC4 structural maintenance of chromosomes 4 0.0309009
RTN4 reticulon 4 0.0308746
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0308635
ANKRD28 ankyrin repeat domain 28 0.0307928
SLC38A2 solute carrier family 38, member 2 0.0307098
ITCH itchy E3 ubiquitin protein ligase 0.0300689
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0299876
RSF1 remodeling and spacing factor 1 0.0298686
PBX3 pre-B-cell leukemia homeobox 3 0.0295193
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0292068
IL6ST interleukin 6 signal transducer 0.0287389
ITGA6 integrin, alpha 6 0.0278813
BABAM2 BRISC and BRCA1 A complex member 2 0.0278651
TPM4 tropomyosin 4 0.0278244
CANX calnexin 0.0277139
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0270272
SCAPER S-phase cyclin A-associated protein in the ER 0.0270059
TAOK1 TAO kinase 1 0.0268548
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0268058
MBNL2 muscleblind-like splicing regulator 2 0.0256215
PKM pyruvate kinase, muscle 0.02561
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0253976
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0252034
CCDC88A coiled-coil domain containing 88A 0.0251117
RECQL RecQ helicase-like 0.0250585
IGFBP3 insulin-like growth factor binding protein 3 0.0247501
ATXN1 ataxin 1 0.0244521
SMAD3 SMAD family member 3 0.0239349
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0238427
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0237011
EHBP1 EH domain binding protein 1 0.0236999
ASXL1 additional sex combs like transcriptional regulator 1 0.0236354
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0231984
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0231962
RNF145 ring finger protein 145 0.0231578
MAP1B microtubule-associated protein 1B 0.0230604
PGK1 phosphoglycerate kinase 1 0.0229508
ANXA2 annexin A2 0.022893
EXOC4 exocyst complex component 4 0.0228095
CKAP5 cytoskeleton associated protein 5 0.0227013
RORA RAR-related orphan receptor A 0.0226411
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0225533
RSRC1 arginine/serine-rich coiled-coil 1 0.0225112
LDHA lactate dehydrogenase A 0.0224551
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0224422
RAD50 RAD50 homolog (S. cerevisiae) 0.0223243
BIRC6 baculoviral IAP repeat containing 6 0.0222297
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0222209
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0221317
GOLGB1 golgin B1 0.0220888
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0220857
BICD1 bicaudal D homolog 1 (Drosophila) 0.021852
FBXL17 F-box and leucine-rich repeat protein 17 0.0217925
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0217851
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0217637
PDE4D phosphodiesterase 4D, cAMP-specific 0.0217629
CENPE centromere protein E, 312kDa 0.021709
RB1CC1 RB1-inducible coiled-coil 1 0.0216302
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0215355
INVS inversin 0.0214939
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0214019
RDX radixin 0.0212793

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.125612
TPT1 tumor protein, translationally-controlled 1 -0.125475
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.085407
TMSB10 thymosin beta 10 -0.059599
RPLP1 ribosomal protein, large, P1 -0.0556417
OASL 2'-5'-oligoadenylate synthetase-like -0.0542701
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0452244
RIGI RNA sensor RIG-I -0.0449877
RPL35A ribosomal protein L35a -0.0412722
EGR1 early growth response 1 -0.0394899
ENO2 enolase 2 (gamma, neuronal) -0.0390835
MT2A metallothionein 2A -0.0385939
GNAS GNAS complex locus -0.038509
IGF2 insulin-like growth factor 2 -0.0380169
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0369366
IER3 immediate early response 3 -0.036201
NDRG1 N-myc downstream regulated 1 -0.0354301
FTH1 ferritin, heavy polypeptide 1 -0.0350017
RPL36 ribosomal protein L36 -0.0329632
S100A9 S100 calcium binding protein A9 -0.0325085
RPL37 ribosomal protein L37 -0.0324267
FOXO3 forkhead box O3 -0.032247
FN1 fibronectin 1 -0.0316906
DLG1 discs, large homolog 1 (Drosophila) -0.0310312
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0305743
RPL31 ribosomal protein L31 -0.0301118
GPC5 glypican 5 -0.0295436
B2M beta-2-microglobulin -0.0289447
RPL37A ribosomal protein L37a -0.0286461
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0284582
RPS6 ribosomal protein S6 -0.0277375
BRD4 bromodomain containing 4 -0.027283
HLA-A major histocompatibility complex, class I, A -0.0270819
RPS13 ribosomal protein S13 -0.0268394
WARS1 tryptophanyl-tRNA synthetase 1 -0.0265049
RPS17 ribosomal protein S17 -0.0255785
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0254984
ANKRD12 ankyrin repeat domain 12 -0.0254264
RPL19 ribosomal protein L19 -0.0252192
RPS21 ribosomal protein S21 -0.0250408
S100A10 S100 calcium binding protein A10 -0.0248674
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0246639
RPS8 ribosomal protein S8 -0.0244974
LOC102724023 ES1 protein homolog, mitochondrial -0.0244236
ANGPTL4 angiopoietin-like 4 -0.0243095
RPS29 ribosomal protein S29 -0.024216
HLA-B major histocompatibility complex, class I, B -0.023963
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.023639
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0234245
SETD5 SET domain containing 5 -0.023308
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0230633
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0228942
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0228842
RPS23 ribosomal protein S23 -0.0228562
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0227439
PANX1 pannexin 1 -0.0222885
RPL27A ribosomal protein L27a -0.0222767
RPS27A ribosomal protein S27a -0.0221982
H3-3B H3.3 histone B -0.022173
EXT1 exostosin glycosyltransferase 1 -0.0221715
SCFD1 sec1 family domain containing 1 -0.0220085
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0219974
NPEPPS aminopeptidase puromycin sensitive -0.0219894
MCTP1 multiple C2 domains, transmembrane 1 -0.0217417
IFI44 interferon-induced protein 44 -0.0217262
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0215474
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0213904
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0212895
SPAG9 sperm associated antigen 9 -0.0212705
RPL23 ribosomal protein L23 -0.0210852
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0210578
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0210106
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0208213
ISG20 interferon stimulated exonuclease gene 20kDa -0.0207447
ISG15 ISG15 ubiquitin-like modifier -0.020742
RALY RALY heterogeneous nuclear ribonucleoprotein -0.020704
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0202978
CDK7 cyclin-dependent kinase 7 -0.0202117
ADM adrenomedullin -0.0201819
MYO9B myosin IXB -0.0198346
SETX senataxin -0.0197731
ARMH4 armadillo like helical domain containing 4 -0.0195863
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0192094
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0191814
HOOK2 hook microtubule-tethering protein 2 -0.0190733
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0190554
INTS6 integrator complex subunit 6 -0.019053
FTL ferritin, light polypeptide -0.0190224
RPS16 ribosomal protein S16 -0.0189711
CHSY1 chondroitin sulfate synthase 1 -0.0189529
IFIH1 interferon induced with helicase C domain 1 -0.0189262
AOPEP aminopeptidase O (putative) -0.0189227
TRAF3 TNF receptor-associated factor 3 -0.0188604
SRSF9 serine/arginine-rich splicing factor 9 -0.0183914
SP100 SP100 nuclear antigen -0.0183371
CREB5 cAMP responsive element binding protein 5 -0.0182939
RPS24 ribosomal protein S24 -0.0181726
JAK1 Janus kinase 1 -0.0181342
CAMK4 calcium/calmodulin-dependent protein kinase IV -0.018126
CAMTA1 calmodulin binding transcription activator 1 -0.0181162