Omeprazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Omeprazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Omeprazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.446561
CANX calnexin 0.146762
ASPH aspartate beta-hydroxylase 0.138434
SQSTM1 sequestosome 1 0.115291
NRG1 neuregulin 1 0.110798
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.106887
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0873712
NAMPT nicotinamide phosphoribosyltransferase 0.0862168
ITGA1 integrin, alpha 1 0.0786788
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0757751
FNDC3B fibronectin type III domain containing 3B 0.0749143
RAI14 retinoic acid induced 14 0.0727619
SFTPA2 surfactant protein A2 0.0686448
TRIO trio Rho guanine nucleotide exchange factor 0.064487
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0616309
NDRG1 N-myc downstream regulated 1 0.0611076
MYH9 myosin, heavy chain 9, non-muscle 0.0583156
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0582638
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0572232
GRB10 growth factor receptor-bound protein 10 0.0563828
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0563438
ERRFI1 ERBB receptor feedback inhibitor 1 0.0548126
GLIS3 GLIS family zinc finger 3 0.0525448
AHR aryl hydrocarbon receptor 0.0524847
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0498378
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.049747
TMSB4X thymosin beta 4, X-linked 0.0493636
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0490681
EXT1 exostosin glycosyltransferase 1 0.0486611
CALR calreticulin 0.0460804
ENO1 enolase 1, (alpha) 0.0457121
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.045432
HIPK2 homeodomain interacting protein kinase 2 0.0451069
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0446183
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.044104
APLP2 amyloid beta (A4) precursor-like protein 2 0.0439379
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0432953
PLIN2 perilipin 2 0.0422304
DST dystonin 0.0412406
STC2 stanniocalcin 2 0.041105
IFI27 interferon, alpha-inducible protein 27 0.040323
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0402105
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0399138
GLUL glutamate-ammonia ligase 0.0392002
CXCL8 chemokine (C-X-C motif) ligand 8 0.038354
PGK1 phosphoglycerate kinase 1 0.0383453
PKM pyruvate kinase, muscle 0.0373181
SPAG9 sperm associated antigen 9 0.0367645
ELL2 elongation factor, RNA polymerase II, 2 0.0363037
VCL vinculin 0.0361644
HILPDA hypoxia inducible lipid droplet-associated 0.0359401
AKAP12 A kinase (PRKA) anchor protein 12 0.0359361
TPR translocated promoter region, nuclear basket protein 0.0356254
LMNA lamin A/C 0.0355641
BZW1 basic leucine zipper and W2 domains 1 0.0348031
CTBP2 C-terminal binding protein 2 0.0347755
MBNL1 muscleblind-like splicing regulator 1 0.0342683
MACF1 microtubule-actin crosslinking factor 1 0.0336721
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0336644
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0335038
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0334747
RICTOR RPTOR independent companion of MTOR, complex 2 0.033315
ARHGAP35 Rho GTPase activating protein 35 0.0331803
SUCO SUN domain containing ossification factor 0.0328121
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326826
HMGA2 high mobility group AT-hook 2 0.0324804
EZR ezrin 0.0320336
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0320223
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0316541
KDM3A lysine (K)-specific demethylase 3A 0.0315449
SOD2 superoxide dismutase 2, mitochondrial 0.0315113
TTC3 tetratricopeptide repeat domain 3 0.0308022
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.030706
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0303747
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0303411
EFNA5 ephrin-A5 0.0299655
LIMCH1 LIM and calponin homology domains 1 0.029869
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0295716
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0293504
HMGB3 high mobility group box 3 0.029342
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0291859
LOXL2 lysyl oxidase-like 2 0.0290569
FAM13A family with sequence similarity 13, member A 0.0289188
VEGFA vascular endothelial growth factor A 0.0283249
CD109 CD109 molecule 0.0279057
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0277151
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0275351
RAB1A RAB1A, member RAS oncogene family 0.0273427
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0271447
RNF213 ring finger protein 213 0.0270683
TXNIP thioredoxin interacting protein 0.0269051
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0262589
KDM5B lysine (K)-specific demethylase 5B 0.0261738
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0261445
CALU calumenin 0.0260913
ANKRD28 ankyrin repeat domain 28 0.0258717
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0257898
INSIG2 insulin induced gene 2 0.0257786
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256071
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.025502

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0832393
RPS6 ribosomal protein S6 -0.0477466
RPL26 ribosomal protein L26 -0.0442718
RPS12 ribosomal protein S12 -0.0400637
FTL ferritin, light polypeptide -0.039737
RPL9 ribosomal protein L9 -0.0370548
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0364775
RPL37A ribosomal protein L37a -0.036332
RPL35A ribosomal protein L35a -0.0327882
RPL23 ribosomal protein L23 -0.0309324
RPS19 ribosomal protein S19 -0.0304662
RPLP1 ribosomal protein, large, P1 -0.0297613
RPS8 ribosomal protein S8 -0.0280763
RPL12 ribosomal protein L12 -0.0272336
RPS29 ribosomal protein S29 -0.0271645
RPL36 ribosomal protein L36 -0.0250169
RPS27 ribosomal protein S27 -0.0247801
RPS25 ribosomal protein S25 -0.0241772
RPL37 ribosomal protein L37 -0.0240967
RPL28 ribosomal protein L28 -0.0240394
RPL34 ribosomal protein L34 -0.0233871
RPS3 ribosomal protein S3 -0.0231366
RPL31 ribosomal protein L31 -0.0223645
RPS16 ribosomal protein S16 -0.0221397
RPLP2 ribosomal protein, large, P2 -0.02195
RPS24 ribosomal protein S24 -0.0217782
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0215821
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0202157
RPLP0 ribosomal protein, large, P0 -0.0200986
TPT1 tumor protein, translationally-controlled 1 -0.0199586
FTH1 ferritin, heavy polypeptide 1 -0.0193336
RPS17 ribosomal protein S17 -0.0186102
TMSB10 thymosin beta 10 -0.0183406
RPL19 ribosomal protein L19 -0.0183268
RPS20 ribosomal protein S20 -0.0173679
RPS14 ribosomal protein S14 -0.0168092
RPS27A ribosomal protein S27a -0.0166964
RPS21 ribosomal protein S21 -0.0159268
RACK1 receptor for activated C kinase 1 -0.0157426
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0155301
ATP5F1E ATP synthase F1 subunit epsilon -0.0146912
SRSF11 serine/arginine-rich splicing factor 11 -0.014644
RPL7 ribosomal protein L7 -0.0143222
NDUFA4 NDUFA4, mitochondrial complex associated -0.0139365
PNISR PNN-interacting serine/arginine-rich protein -0.0133992
RPL18 ribosomal protein L18 -0.0131983
RPL30 ribosomal protein L30 -0.0130027
RPS23 ribosomal protein S23 -0.012853
RPL21 ribosomal protein L21 -0.0126671
RPL36AL ribosomal protein L36a-like -0.0126181
HMGA1 high mobility group AT-hook 1 -0.0124741
RPL5 ribosomal protein L5 -0.0124356
RPL36A ribosomal protein L36a -0.0123226
RPL32 ribosomal protein L32 -0.0119446
HMGB1 high mobility group box 1 -0.0119154
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0117786
RPL7A ribosomal protein L7a -0.011614
RPL11 ribosomal protein L11 -0.0116044
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0115908
EIF5B eukaryotic translation initiation factor 5B -0.0114486
MGST1 microsomal glutathione S-transferase 1 -0.0114303
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0113614
RPL35 ribosomal protein L35 -0.0113225
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0110553
RPS26 ribosomal protein S26 -0.0109244
RPS5 ribosomal protein S5 -0.0108461
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0108341
COX7C cytochrome c oxidase subunit VIIc -0.0107803
AREG amphiregulin -0.0102366
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0101968
RPL27 ribosomal protein L27 -0.010125
PFN1 profilin 1 -0.0100611
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00998756
RPL13A ribosomal protein L13a -0.00963906
UGCG UDP-glucose ceramide glucosyltransferase -0.00955581
SEC61G Sec61 gamma subunit -0.00950433
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.00945908
CAB39 calcium binding protein 39 -0.00942122
S100A9 S100 calcium binding protein A9 -0.00921008
GPR107 G protein-coupled receptor 107 -0.00916707
YBX1 Y box binding protein 1 -0.00909128
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0090606
S100A10 S100 calcium binding protein A10 -0.00904527
FBXL5 F-box and leucine-rich repeat protein 5 -0.00891001
RPS13 ribosomal protein S13 -0.00884339
FOSL1 FOS-like antigen 1 -0.0086908
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.00852205
SMC4 structural maintenance of chromosomes 4 -0.0083963
RPS11 ribosomal protein S11 -0.00833586
DIAPH3 diaphanous-related formin 3 -0.0082888
BTG1 B-cell translocation gene 1, anti-proliferative -0.00818699
TNPO3 transportin 3 -0.00816219
PDCD5 programmed cell death 5 -0.00811567
ATP5MG ATP synthase membrane subunit g -0.00811527
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.00806471
RBPMS RNA binding protein with multiple splicing -0.0079808
SOS1 son of sevenless homolog 1 (Drosophila) -0.00797927
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00796265
RBM25 RNA binding motif protein 25 -0.00794855
CBX3 chromobox homolog 3 -0.00786411