Omphalocele Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A physical disorder characterized by a defect in the development of the abdominal wall muscles, resulting in the intestines, liver and other organs to remain outside of the abdomen in a sac. (Human Disease Ontology, DOID_0060327)
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Genes

222 genes co-occuring with the disease Omphalocele in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 2.698
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 2.692
AFP alpha-fetoprotein 2.42
IGF2 insulin-like growth factor 2 2.26
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.055
FOXF1 forkhead box F1 2.055
PITX2 paired-like homeodomain 2 2.046
MNX1 motor neuron and pancreas homeobox 1 2.01
SHH sonic hedgehog 1.953
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.946
ALX4 ALX homeobox 4 1.927
RTL1 retrotransposon-like 1 1.909
TGM1 transglutaminase 1 1.9
FREM1 FRAS1 related extracellular matrix 1 1.876
WDR20 WD repeat domain 20 1.857
ATXN1L ataxin 1-like 1.846
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 1.816
GLI3 GLI family zinc finger 3 1.794
FLNA filamin A, alpha 1.721
NOAZFP nucleolar atypical zinc finger 1.713
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 1.712
MSX1 msh homeobox 1 1.708
PLAGL1 pleiomorphic adenoma gene-like 1 1.687
ZIC3 Zic family member 3 1.685
MSX2 msh homeobox 2 1.649
EFCAB7 EF-hand calcium binding domain 7 1.643
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.642
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.623
CIC capicua transcriptional repressor 1.613
PODXL podocalyxin-like 1.6
DLK1 delta-like 1 homolog (Drosophila) 1.597
MEST mesoderm specific transcript 1.587
PORCN porcupine homolog (Drosophila) 1.584
WT1 Wilms tumor 1 1.581
UROD uroporphyrinogen decarboxylase 1.562
HOXB4 homeobox B4 1.55
TRIP11 thyroid hormone receptor interactor 11 1.539
GPC3 glypican 3 1.528
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.527
MORN1 MORN repeat containing 1 1.525
FRAS1 Fraser extracellular matrix complex subunit 1 1.505
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.504
TBC1D32 TBC1 domain family, member 32 1.495
LRP2 low density lipoprotein receptor-related protein 2 1.493
MSGN1 mesogenin 1 1.48
IFT27 intraflagellar transport 27 1.474
TMEM94 transmembrane protein 94 1.469
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 1.463
GNAS GNAS complex locus 1.458
PTCH1 patched 1 1.457
BMP4 bone morphogenetic protein 4 1.451
GLI2 GLI family zinc finger 2 1.431
ALX3 ALX homeobox 3 1.423
SIX4 SIX homeobox 4 1.422
GRB10 growth factor receptor-bound protein 10 1.413
DGKK diacylglycerol kinase, kappa 1.408
MTHFSD methenyltetrahydrofolate synthetase domain containing 1.403
TLE6 transducin-like enhancer of split 6 1.403
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.399
IFT80 intraflagellar transport 80 1.399
TMEM67 transmembrane protein 67 1.376
MYH10 myosin, heavy chain 10, non-muscle 1.376
NUGGC nuclear GTPase, germinal center associated 1.375
FGFR2 fibroblast growth factor receptor 2 1.371
IFT140 intraflagellar transport 140 1.37
IGF2R insulin-like growth factor 2 receptor 1.369
ISL1 ISL LIM homeobox 1 1.366
HOXD13 homeobox D13 1.359
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.359
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.356
SNRPN small nuclear ribonucleoprotein polypeptide N 1.351
MYH14 myosin, heavy chain 14, non-muscle 1.345
EFNB1 ephrin-B1 1.342
ZNF189 zinc finger protein 189 1.337
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 1.335
IHH indian hedgehog 1.334
NSD1 nuclear receptor binding SET domain protein 1 1.331
CHD7 chromodomain helicase DNA binding protein 7 1.326
TBX18 T-box 18 1.322
FAM241A family with sequence similarity 241 member A 1.32
ZGRF1 zinc finger, GRF-type containing 1 1.313
ZFP57 ZFP57 zinc finger protein 1.308
FOXA2 forkhead box A2 1.307
TMEM262 transmembrane protein 262 1.305
COLEC11 collectin sub-family member 11 1.302
NLRP2 NLR family, pyrin domain containing 2 1.302
NLRP7 NLR family, pyrin domain containing 7 1.297
WNT5A wingless-type MMTV integration site family, member 5A 1.291
GATA4 GATA binding protein 4 1.286
ATXN1 ataxin 1 1.285
CDKN3 cyclin-dependent kinase inhibitor 3 1.284
TCN2 transcobalamin II 1.282
CNTNAP3 contactin associated protein-like 3 1.275
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.273
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.273
TMEM260 transmembrane protein 260 1.272
GIPC3 GIPC PDZ domain containing family, member 3 1.269
SIX5 SIX homeobox 5 1.263
FREM2 FRAS1 related extracellular matrix protein 2 1.26
MYRF myelin regulatory factor 1.26
CTCF CCCTC-binding factor (zinc finger protein) 1.259
STRA6 stimulated by retinoic acid 6 1.253
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.252
GLI1 GLI family zinc finger 1 1.25
SOX12 SRY (sex determining region Y)-box 12 1.247
FOXL1 forkhead box L1 1.245
NXPH2 neurexophilin 2 1.243
FAM171B family with sequence similarity 171, member B 1.242
NKX2-5 NK2 homeobox 5 1.239
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.238
ACHE acetylcholinesterase (Yt blood group) 1.237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.235
SMO smoothened, frizzled class receptor 1.233
RHOA ras homolog family member A 1.233
EZR ezrin 1.232
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 1.231
DVL1 dishevelled segment polarity protein 1 1.231
TTC7A tetratricopeptide repeat domain 7A 1.23
FOXC1 forkhead box C1 1.227
HMSD histocompatibility (minor) serpin domain containing 1.222
ZFPM2 zinc finger protein, FOG family member 2 1.222
NLRP5 NLR family, pyrin domain containing 5 1.215
WNT9B wingless-type MMTV integration site family, member 9B 1.21
SLC22A18 solute carrier family 22, member 18 1.208
SOX9 SRY (sex determining region Y)-box 9 1.207
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.201
ZIC2 Zic family member 2 1.2
EMC4 ER membrane protein complex subunit 4 1.197
PODXL2 podocalyxin-like 2 1.197
RDX radixin 1.19
VANGL1 VANGL planar cell polarity protein 1 1.19
FGF10 fibroblast growth factor 10 1.182
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 1.174
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.173
GRAP2 GRB2-related adaptor protein 2 1.173
BMPR1A bone morphogenetic protein receptor, type IA 1.173
MAP2K2 mitogen-activated protein kinase kinase 2 1.17
TSSC4 tumor suppressing subtransferable candidate 4 1.168
PGM1 phosphoglucomutase 1 1.167
THAP7 THAP domain containing 7 1.167
EPHB3 EPH receptor B3 1.165
FGFR1 fibroblast growth factor receptor 1 1.165
TBX1 T-box 1 1.159
DVL3 dishevelled segment polarity protein 3 1.159
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 1.159
SOX11 SRY (sex determining region Y)-box 11 1.159
GLCE glucuronic acid epimerase 1.157
BMP1 bone morphogenetic protein 1 1.156
BMS1 BMS1 ribosome biogenesis factor 1.155
INS insulin 1.154
AHDC1 AT hook, DNA binding motif, containing 1 1.153
MAGIX MAGI family member, X-linked 1.153
AP1AR adaptor-related protein complex 1 associated regulatory protein 1.153
WDR81 WD repeat domain 81 1.151
IRF6 interferon regulatory factor 6 1.15
OOEP oocyte expressed protein 1.148
GTDC1 glycosyltransferase-like domain containing 1 1.141
COLEC10 collectin sub-family member 10 (C-type lectin) 1.139
MAGEL2 melanoma antigen family L2 1.133
FGF8 fibroblast growth factor 8 (androgen-induced) 1.13
DIO3 deiodinase, iodothyronine, type III 1.129
WNT11 wingless-type MMTV integration site family, member 11 1.128
RXYLT1 ribitol xylosyltransferase 1 1.126
SRY sex determining region Y 1.122
MYH9 myosin, heavy chain 9, non-muscle 1.122
CFL2 cofilin 2 (muscle) 1.121
PAX6 paired box 6 1.12
ALX1 ALX homeobox 1 1.119
TMEM138 transmembrane protein 138 1.117
LIMK1 LIM domain kinase 1 1.116
MARCKS myristoylated alanine-rich protein kinase C substrate 1.112
NXN nucleoredoxin 1.11
TMEM237 transmembrane protein 237 1.107
COG5 component of oligomeric golgi complex 5 1.107
CCP110 centriolar coiled coil protein 110kDa 1.107
KYNU kynureninase 1.104
FAM50B family with sequence similarity 50, member B 1.098
BMP2 bone morphogenetic protein 2 1.096
PAX3 paired box 3 1.095
ACTG2 actin, gamma 2, smooth muscle, enteric 1.094
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.09
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 1.086
TMEM231 transmembrane protein 231 1.08
CALR calreticulin 1.077
CFC1 cripto, FRL-1, cryptic family 1 1.075
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.075
CCNQ cyclin Q 1.074
MMP23B matrix metallopeptidase 23B 1.074
ALG3 ALG3, alpha-1,3- mannosyltransferase 1.07
ALB albumin 1.067
HOXB2 homeobox B2 1.066
MSN moesin 1.066
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.061
TBX6 T-box 6 1.06
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.06
FMN2 formin 2 1.052
SIX6 SIX homeobox 6 1.052
ATCAY ataxia, cerebellar, Cayman type 1.051
FLNB filamin B, beta 1.05
DSE dermatan sulfate epimerase 1.044
CLDN16 claudin 16 1.04
WNT3 wingless-type MMTV integration site family, member 3 1.038
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.037
KHDC3L KH domain containing 3-like, subcortical maternal complex member 1.034
WDR35 WD repeat domain 35 1.032
ADD3 adducin 3 (gamma) 1.032
EFNB2 ephrin-B2 1.029
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 1.028
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 1.021
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 1.017
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 1.016
COL2A1 collagen, type II, alpha 1 1.014
GPC4 glypican 4 1.014
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.012
IFT88 intraflagellar transport 88 1.012
SIX1 SIX homeobox 1 1.008
PDZD2 PDZ domain containing 2 1.006
TWIST2 twist family bHLH transcription factor 2 1.004
LHB luteinizing hormone beta polypeptide 1.004
UNCX UNC homeobox 1.004
RAX2 retina and anterior neural fold homeobox 2 1.003
SCRIB scribbled planar cell polarity protein 1.001