Onchocerciasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. (Human Disease Ontology, DOID_11678)
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Genes

140 genes co-occuring with the disease Onchocerciasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
LMOD1 leiomodin 1 (smooth muscle) 2.714
IL5 interleukin 5 2.322
IL10 interleukin 10 2.132
IL4 interleukin 4 2.12
IFNG interferon, gamma 2.05
ERV3-1 endogenous retrovirus group 3, member 1 2.001
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.0
CD4 CD4 molecule 2.0
IL13 interleukin 13 1.992
ERVW-1 endogenous retrovirus group W, member 1 1.95
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 1.876
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.864
DSG1 desmoglein 1 1.819
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.798
EPX eosinophil peroxidase 1.796
IL2 interleukin 2 1.783
RBP3 retinol binding protein 3, interstitial 1.761
TGFB1 transforming growth factor, beta 1 1.735
TLR2 toll-like receptor 2 1.712
RNASE3 ribonuclease, RNase A family, 3 1.71
IL6 interleukin 6 1.695
TNF tumor necrosis factor 1.659
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 1.641
IL4R interleukin 4 receptor 1.624
CD8A CD8a molecule 1.612
CCL11 chemokine (C-C motif) ligand 11 1.603
FAR2 fatty acyl CoA reductase 2 1.599
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.581
CHIA chitinase, acidic 1.577
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.575
FOXP3 forkhead box P3 1.567
IL1B interleukin 1, beta 1.555
IL17A interleukin 17A 1.528
TXNRD3 thioredoxin reductase 3 1.52
TLR6 toll-like receptor 6 1.517
CHIT1 chitinase 1 (chitotriosidase) 1.513
TLR4 toll-like receptor 4 1.504
ALB albumin 1.48
ONECUT3 one cut homeobox 3 1.465
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 1.46
ACE2 angiotensin I converting enzyme 2 1.448
CCL3 chemokine (C-C motif) ligand 3 1.424
TMOD2 tropomodulin 2 (neuronal) 1.421
CXCL8 chemokine (C-X-C motif) ligand 8 1.413
KRTAP1-3 keratin associated protein 1-3 1.407
SOX3 SRY (sex determining region Y)-box 3 1.389
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 1.385
ADGRL1 adhesion G protein-coupled receptor L1 1.381
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.375
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.373
CTSL cathepsin L 1.372
CCL5 chemokine (C-C motif) ligand 5 1.368
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.368
SH2D3A SH2 domain containing 3A 1.364
TMOD3 tropomodulin 3 (ubiquitous) 1.363
S100A9 S100 calcium binding protein A9 1.352
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.341
HPGDS hematopoietic prostaglandin D synthase 1.335
TRIM21 tripartite motif containing 21 1.335
COPS7A COP9 signalosome subunit 7A 1.333
TMOD1 tropomodulin 1 1.332
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.327
SAG S-antigen; retina and pineal gland (arrestin) 1.32
MAGEH1 melanoma antigen family H1 1.313
TMOD4 tropomodulin 4 (muscle) 1.311
AAK1 AP2 associated kinase 1 1.309
TCF15 transcription factor 15 (basic helix-loop-helix) 1.309
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.297
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.294
PXDN peroxidasin 1.293
CALR calreticulin 1.288
PXDNL peroxidasin-like 1.286
TMPRSS2 transmembrane protease, serine 2 1.286
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 1.285
IL1A interleukin 1, alpha 1.284
IL9 interleukin 9 1.279
ALAD aminolevulinate dehydratase 1.279
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.277
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 1.275
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.262
APOD apolipoprotein D 1.239
RCN1 reticulocalbin 1, EF-hand calcium binding domain 1.222
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 1.219
CCL4 chemokine (C-C motif) ligand 4 1.216
MYD88 myeloid differentiation primary response 88 1.198
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1.198
ZAN zonadhesin (gene/pseudogene) 1.195
CXCL10 chemokine (C-X-C motif) ligand 10 1.182
CTRL chymotrypsin-like 1.176
CCDC85A coiled-coil domain containing 85A 1.175
SHPK sedoheptulokinase 1.17
IL33 interleukin 33 1.168
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.167
FECH ferrochelatase 1.166
TLR1 toll-like receptor 1 1.164
MT4 metallothionein 4 1.157
TLR3 toll-like receptor 3 1.152
VEGFC vascular endothelial growth factor C 1.146
CCL2 chemokine (C-C motif) ligand 2 1.143
LMOD2 leiomodin 2 (cardiac) 1.143
IL19 interleukin 19 1.136
CRISP1 cysteine-rich secretory protein 1 1.132
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 1.131
RO60 Ro60, Y RNA binding protein 1.131
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.127
IFNA1 interferon, alpha 1 1.126
PGLYRP1 peptidoglycan recognition protein 1 1.119
TPP2 tripeptidyl peptidase II 1.113
KPNB1 karyopherin (importin) beta 1 1.113
TBL1X transducin (beta)-like 1X-linked 1.109
LGMN legumain 1.108
ADGRL2 adhesion G protein-coupled receptor L2 1.104
IFNB1 interferon, beta 1, fibroblast 1.104
AJM1 apical junction component 1 homolog 1.099
RNASE13 ribonuclease, RNase A family, 13 (non-active) 1.099
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 1.097
TSLP thymic stromal lymphopoietin 1.094
CST4 cystatin S 1.077
CRISP2 cysteine-rich secretory protein 2 1.072
CCL17 chemokine (C-C motif) ligand 17 1.062
DHFR dihydrofolate reductase 1.062
CTSS cathepsin S 1.062
ANK2 ankyrin 2, neuronal 1.053
CTSG cathepsin G 1.049
FGF2 fibroblast growth factor 2 (basic) 1.044
LTF lactotransferrin 1.042
CLC Charcot-Leyden crystal galectin 1.037
TLR9 toll-like receptor 9 1.036
CCL13 chemokine (C-C motif) ligand 13 1.034
SDF4 stromal cell derived factor 4 1.029
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.028
SIRT5 sirtuin 5 1.027
DHFR2 dihydrofolate reductase 2 1.025
CCL24 chemokine (C-C motif) ligand 24 1.02
PRB1 proline-rich protein BstNI subfamily 1 1.019
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.018
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 1.006
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.006
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.003
CRP C-reactive protein, pentraxin-related 1.002