Onchocerciasis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. (Human Disease Ontology, DOID_11678)
External Link https://www.disgenet.org/browser/0/1/0/C0029001
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Genes

19 genes associated with the disease Onchocerciasis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
CALR calreticulin
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP4 FK506 binding protein 4, 59kDa
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2
GSTA1 glutathione S-transferase alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNF4A hepatocyte nuclear factor 4, alpha
HPGDS hematopoietic prostaglandin D synthase
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL10 interleukin 10
IL13 interleukin 13
IL2 interleukin 2
IL4 interleukin 4
IL5 interleukin 5
LRP2 low density lipoprotein receptor-related protein 2
MCF2L MCF.2 cell line derived transforming sequence-like
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RNASE13 ribonuclease, RNase A family, 13 (non-active)
SOSTDC1 sclerostin domain containing 1