Oocyte meiosis Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle. (Kyoto Encyclopedia of Genes and Genomes, hsa04114)
External Link https://www.kegg.jp/entry/hsa04114
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Genes

136 proteins participating in the Oocyte meiosis pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC13 anaphase promoting complex subunit 13
ANAPC15 anaphase promoting complex subunit 15
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
AREG amphiregulin
AURKA aurora kinase A
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML4 calmodulin-like 4
CALML5 calmodulin-like 5
CALML6 calmodulin-like 6
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC25C cell division cycle 25C
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPEB2 cytoplasmic polyadenylation element binding protein 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPEB4 cytoplasmic polyadenylation element binding protein 4
CUL1 cullin 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FBXO43 F-box protein 43
FBXO5 F-box protein 5
FBXW11 F-box and WD repeat domain containing 11
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
INS insulin
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LNCOG lncRNA osteogenesis associated
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MOCOS molybdenum cofactor sulfurase
PGR progesterone receptor
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLCZ1 phospholipase C, zeta 1
PLK1 polo-like kinase 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP3R2 protein phosphatase 3, regulatory subunit B, beta
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PTTG1 pituitary tumor-transforming 1
PTTG2 pituitary tumor-transforming 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
REC8 REC8 meiotic recombination protein
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SGO1 shugoshin 1
SKP1 S-phase kinase-associated protein 1
SLK STE20-like kinase
SMC1A structural maintenance of chromosomes 1A
SMC1B structural maintenance of chromosomes 1B
SMC3 structural maintenance of chromosomes 3
SPDYA speedy/RINGO cell cycle regulator family member A
SPDYC speedy/RINGO cell cycle regulator family member C
SPDYE1 speedy/RINGO cell cycle regulator family member E1
SPDYE10 speedy/RINGO cell cycle regulator family member E10
SPDYE11 speedy/RINGO cell cycle regulator family member E11
SPDYE12 speedy/RINGO cell cycle regulator family member E12
SPDYE13 speedy/RINGO cell cycle regulator family member E13
SPDYE14 speedy/RINGO cell cycle regulator family member E14
SPDYE16 speedy/RINGO cell cycle regulator family member E16
SPDYE17 speedy/RINGO cell cycle regulator family member E17
SPDYE18 speedy/RINGO cell cycle regulator family member E18
SPDYE2 speedy/RINGO cell cycle regulator family member E2
SPDYE21 speedy/RINGO cell cycle regulator family member E21
SPDYE2B speedy/RINGO cell cycle regulator family member E2B
SPDYE3 speedy/RINGO cell cycle regulator family member E3
SPDYE4 speedy/RINGO cell cycle regulator family member E4
SPDYE5 speedy/RINGO cell cycle regulator family member E5
SPDYE6 speedy/RINGO cell cycle regulator family member E6
SPDYE8 speedy/RINGO cell cycle regulator family member E8
STAG3 stromal antigen 3
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta