Optic Neuritis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision. (Human Disease Ontology, DOID_1210)
External Link https://www.disgenet.org/browser/0/1/0/C0029134
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Genes

77 genes associated with the disease Optic Neuritis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
APOE apolipoprotein E
AQP4 aquaporin 4
ASCC2 activating signal cointegrator 1 complex subunit 2
AVPR2 arginine vasopressin receptor 2
BDNF brain-derived neurotrophic factor
CAPN1 calpain 1, (mu/I) large subunit
CAT catalase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD19 CD19 molecule
CD27 CD27 molecule
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CNR1 cannabinoid receptor 1 (brain)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CUX1 cut-like homeobox 1
CXCL13 chemokine (C-X-C motif) ligand 13
DPYSL5 dihydropyrimidinase-like 5
EDN1 endothelin 1
FAS Fas cell surface death receptor
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GFAP glial fibrillary acidic protein
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HCRT hypocretin (orexin) neuropeptide precursor
HLA-A major histocompatibility complex, class I, A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
IFNG interferon, gamma
IL10 interleukin 10
IL17A interleukin 17A
IL17D interleukin 17D
IL27 interleukin 27
IL4 interleukin 4
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LAMC2 laminin, gamma 2
LINGO1 leucine rich repeat and Ig domain containing 1
MAG myelin associated glycoprotein
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCH11 membrane-associated ring finger (C3HC4) 11
MBP myelin basic protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MOG myelin oligodendrocyte glycoprotein
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLXNA2 plexin A2
PMEL premelanosome protein
POLG polymerase (DNA directed), gamma
POU2F3 POU class 2 homeobox 3
PRKCD protein kinase C, delta
RASD1 RAS, dexamethasone-induced 1
RASL12 RAS-like, family 12
RBM45 RNA binding motif protein 45
REN renin
RTN4R reticulon 4 receptor
SART3 squamous cell carcinoma antigen recognized by T cells 3
SDC1 syndecan 1
SND1 staphylococcal nuclease and tudor domain containing 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TG thyroglobulin
TK2 thymidine kinase 2, mitochondrial
TNF tumor necrosis factor
TPO thyroid peroxidase
TPX2 TPX2, microtubule-associated