Ornidazole_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.158355
MEF2A myocyte enhancer factor 2A 0.140758
TOP2A topoisomerase (DNA) II alpha 170kDa 0.132619
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.126457
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0979664
HELZ helicase with zinc finger 0.0977364
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0860641
LSAMP limbic system-associated membrane protein 0.0836692
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0821431
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0811875
SETD5 SET domain containing 5 0.0762273
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0759649
IGF2 insulin-like growth factor 2 0.0758797
MSI2 musashi RNA-binding protein 2 0.0753791
FNDC3B fibronectin type III domain containing 3B 0.0749105
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0747068
RNF145 ring finger protein 145 0.0631002
VEGFA vascular endothelial growth factor A 0.0620828
WAC WW domain containing adaptor with coiled-coil 0.0615471
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0614299
ZMIZ1 zinc finger, MIZ-type containing 1 0.060609
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0598978
PCDH9 protocadherin 9 0.0581229
CENPF centromere protein F, 350/400kDa 0.0550278
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0538975
MYH9 myosin, heavy chain 9, non-muscle 0.0533247
NDRG1 N-myc downstream regulated 1 0.0522906
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0518778
B2M beta-2-microglobulin 0.0512599
PTPRM protein tyrosine phosphatase, receptor type, M 0.0506068
VMP1 vacuole membrane protein 1 0.0501623
QKI QKI, KH domain containing, RNA binding 0.0500008
SIK3 SIK family kinase 3 0.0494613
MACF1 microtubule-actin crosslinking factor 1 0.0484757
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0480213
PDE4D phosphodiesterase 4D, cAMP-specific 0.0461834
MKI67 marker of proliferation Ki-67 0.0461123
WSB1 WD repeat and SOCS box containing 1 0.0459534
GPBP1 GC-rich promoter binding protein 1 0.0453764
LINGO2 leucine rich repeat and Ig domain containing 2 0.0447531
NPEPPS aminopeptidase puromycin sensitive 0.0444972
WDR45B WD repeat domain 45B 0.0435058
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0428947
PKM pyruvate kinase, muscle 0.0417537
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0416576
C1ORF21 chromosome 1 open reading frame 21 0.0414682
CDC27 cell division cycle 27 0.0414192
EXT1 exostosin glycosyltransferase 1 0.041068
ZNF148 zinc finger protein 148 0.0410493
SLITRK6 SLIT and NTRK-like family, member 6 0.0407985
RPS3 ribosomal protein S3 0.0405297
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0401703
RPL3 ribosomal protein L3 0.0396435
HILPDA hypoxia inducible lipid droplet-associated 0.0391475
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0391047
ANTXR1 anthrax toxin receptor 1 0.0390409
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0388386
TPR translocated promoter region, nuclear basket protein 0.0385934
KDM2A lysine (K)-specific demethylase 2A 0.0384768
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0384532
CADM1 cell adhesion molecule 1 0.0383865
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0380733
CCNY cyclin Y 0.0380355
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0379731
KTN1 kinectin 1 (kinesin receptor) 0.0379364
RUNX1 runt-related transcription factor 1 0.03782
PHIP pleckstrin homology domain interacting protein 0.0372614
PTPRD protein tyrosine phosphatase, receptor type, D 0.0372461
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0371848
SEC31A SEC31 homolog A (S. cerevisiae) 0.0369303
BRWD1 bromodomain and WD repeat domain containing 1 0.0367896
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0367197
PBX1 pre-B-cell leukemia homeobox 1 0.0365797
ITPRID2 ITPR interacting domain containing 2 0.0361267
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.03589
KCTD3 potassium channel tetramerization domain containing 3 0.0358309
RSF1 remodeling and spacing factor 1 0.0355708
PICALM phosphatidylinositol binding clathrin assembly protein 0.0347875
RBM6 RNA binding motif protein 6 0.0347763
DTNA dystrobrevin, alpha 0.0347133
TIMP3 TIMP metallopeptidase inhibitor 3 0.0344959
COPA coatomer protein complex, subunit alpha 0.0341714
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0335067
RTN4 reticulon 4 0.0333965
HSPA8 heat shock 70kDa protein 8 0.0333876
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0330134
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0327345
GIGYF2 GRB10 interacting GYF protein 2 0.0322087
PDS5B PDS5 cohesin associated factor B 0.0320943
KDM6A lysine (K)-specific demethylase 6A 0.0318763
TIMP2 TIMP metallopeptidase inhibitor 2 0.0317902
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0316796
CASC3 cancer susceptibility candidate 3 0.0316064
ARHGAP9 Rho GTPase activating protein 9 0.0315492
CSNK1A1 casein kinase 1, alpha 1 0.031539
PACS1 phosphofurin acidic cluster sorting protein 1 0.0314778
PCBP3 poly(rC) binding protein 3 0.0312621
ZCCHC7 zinc finger, CCHC domain containing 7 0.0307632
SBF2 SET binding factor 2 0.030763
TPM1 tropomyosin 1 (alpha) 0.0304908

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.134962
TRIB2 tribbles pseudokinase 2 -0.115277
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100475
COL1A1 collagen, type I, alpha 1 -0.0945787
MAP1B microtubule-associated protein 1B -0.0890776
COL3A1 collagen, type III, alpha 1 -0.0717677
TPST1 tyrosylprotein sulfotransferase 1 -0.0701863
EEF2 eukaryotic translation elongation factor 2 -0.0542496
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0514478
RNF213 ring finger protein 213 -0.0511557
RIGI RNA sensor RIG-I -0.0465982
GNAS GNAS complex locus -0.0461618
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0460399
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0449598
AHNAK AHNAK nucleoprotein -0.0419275
RPLP1 ribosomal protein, large, P1 -0.0413926
RPL38 ribosomal protein L38 -0.0413587
ARF1 ADP-ribosylation factor 1 -0.0410396
FKBP10 FK506 binding protein 10, 65 kDa -0.0393084
FTH1 ferritin, heavy polypeptide 1 -0.0385399
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0380366
NALF1 NALCN channel auxiliary factor 1 -0.0380275
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0380043
CRABP2 cellular retinoic acid binding protein 2 -0.0364802
VGF VGF nerve growth factor inducible -0.0363612
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0357268
GAB2 GRB2-associated binding protein 2 -0.0355997
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0355141
IFI16 interferon, gamma-inducible protein 16 -0.0352642
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0345003
LMAN1 lectin, mannose-binding, 1 -0.0341542
RPL23 ribosomal protein L23 -0.0339883
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0331864
CCDC47 coiled-coil domain containing 47 -0.033156
UNC5C unc-5 homolog C (C. elegans) -0.0323095
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0323035
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -0.0318366
PTPRK protein tyrosine phosphatase, receptor type, K -0.0316417
AOPEP aminopeptidase O (putative) -0.0314948
HAND2 heart and neural crest derivatives expressed 2 -0.0311004
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0296102
RPS24 ribosomal protein S24 -0.0295579
CHD1 chromodomain helicase DNA binding protein 1 -0.0295233
TOX thymocyte selection-associated high mobility group box -0.0291755
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0285568
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.028122
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0277621
CUL1 cullin 1 -0.0273944
MMP2 matrix metallopeptidase 2 -0.0273363
PHF3 PHD finger protein 3 -0.0270417
KLF6 Kruppel-like factor 6 -0.0266101
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0266059
RPS6 ribosomal protein S6 -0.0265575
TPT1 tumor protein, translationally-controlled 1 -0.0265387
LOC112694756 uncharaterized LOC112694756 -0.0264407
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0263558
AKAP12 A kinase (PRKA) anchor protein 12 -0.0259926
HBP1 HMG-box transcription factor 1 -0.0258818
HMGA1 high mobility group AT-hook 1 -0.0258464
TRIP12 thyroid hormone receptor interactor 12 -0.0253754
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0252769
ATP5F1B ATP synthase F1 subunit beta -0.0252295
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0250781
NEK1 NIMA-related kinase 1 -0.025059
S100A6 S100 calcium binding protein A6 -0.0247256
ACTG1 actin gamma 1 -0.0245696
RSL1D1 ribosomal L1 domain containing 1 -0.0239238
ANKRD10 ankyrin repeat domain 10 -0.0238908
RHOBTB3 Rho-related BTB domain containing 3 -0.0237204
ZNF804A zinc finger protein 804A -0.0236355
EIF4A2 eukaryotic translation initiation factor 4A2 -0.023329
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0233137
GLCCI1 glucocorticoid induced 1 -0.0232806
GOSR2 golgi SNAP receptor complex member 2 -0.0229771
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0226739
MORF4L2 mortality factor 4 like 2 -0.0224724
FRS2 fibroblast growth factor receptor substrate 2 -0.0223982
HDLBP high density lipoprotein binding protein -0.0217969
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0217913
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0217431
CLTC clathrin, heavy chain (Hc) -0.0217027
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0216169
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0215901
FOXK2 forkhead box K2 -0.0214478
SDK1 sidekick cell adhesion molecule 1 -0.0214257
KLHL24 kelch-like family member 24 -0.0211769
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0210138
BLZF1 basic leucine zipper nuclear factor 1 -0.0209386
ATF6 activating transcription factor 6 -0.020761
WARS1 tryptophanyl-tRNA synthetase 1 -0.0207337
ZNF609 zinc finger protein 609 -0.0206128
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0203672
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0202487
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0201224
SOX4 SRY (sex determining region Y)-box 4 -0.0199508
METTL16 methyltransferase like 16 -0.0198585
RPL23A ribosomal protein L23a -0.0198218
BSG basigin (Ok blood group) -0.0196721
SLC38A1 solute carrier family 38, member 1 -0.0195074
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0194323