Ornidazole_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.22526
NDRG1 N-myc downstream regulated 1 0.147781
CADM1 cell adhesion molecule 1 0.126242
COL6A3 collagen, type VI, alpha 3 0.125634
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.114853
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.110682
VEGFA vascular endothelial growth factor A 0.110179
ATP13A3 ATPase type 13A3 0.0965366
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.096511
PTK2 protein tyrosine kinase 2 0.089111
FNDC3B fibronectin type III domain containing 3B 0.0829814
PDE10A phosphodiesterase 10A 0.0734573
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0726062
ZNF292 zinc finger protein 292 0.0698477
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0682878
ZFAND3 zinc finger, AN1-type domain 3 0.0675967
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0614127
DLG1 discs, large homolog 1 (Drosophila) 0.0608794
NAV2 neuron navigator 2 0.0601066
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0583948
ANKRD11 ankyrin repeat domain 11 0.0582614
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0573924
MYH9 myosin, heavy chain 9, non-muscle 0.0561466
JARID2 jumonji, AT rich interactive domain 2 0.0533129
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0532374
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0525772
ERRFI1 ERBB receptor feedback inhibitor 1 0.0516583
MRTFA myocardin related transcription factor A 0.0483605
DOCK5 dedicator of cytokinesis 5 0.0477114
CDH13 cadherin 13 0.0469829
SETD5 SET domain containing 5 0.0466959
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0441828
FMNL2 formin-like 2 0.0437688
KMT2E lysine (K)-specific methyltransferase 2E 0.0433603
ADAM17 ADAM metallopeptidase domain 17 0.0429582
SMAD3 SMAD family member 3 0.0425495
ELL2 elongation factor, RNA polymerase II, 2 0.0417994
RASA2 RAS p21 protein activator 2 0.040891
RICTOR RPTOR independent companion of MTOR, complex 2 0.040454
COPA coatomer protein complex, subunit alpha 0.0403666
HIPK2 homeodomain interacting protein kinase 2 0.0395613
TIMP3 TIMP metallopeptidase inhibitor 3 0.0393296
MED13L mediator complex subunit 13-like 0.0389006
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0389003
QKI QKI, KH domain containing, RNA binding 0.0384547
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0381356
CAMTA1 calmodulin binding transcription activator 1 0.0379766
STC1 stanniocalcin 1 0.03787
RUNX1 runt-related transcription factor 1 0.0376898
GOLGA4 golgin A4 0.0372834
KMT2C lysine (K)-specific methyltransferase 2C 0.0364704
NAMPT nicotinamide phosphoribosyltransferase 0.0358574
TFG TRK-fused gene 0.0354571
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.03529
SPAG9 sperm associated antigen 9 0.0352004
HIP1 huntingtin interacting protein 1 0.0350263
RAB6A RAB6A, member RAS oncogene family 0.034928
CCNY cyclin Y 0.0347933
ESYT2 extended synaptotagmin-like protein 2 0.0334987
RNF145 ring finger protein 145 0.0326959
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.03266
WSB1 WD repeat and SOCS box containing 1 0.0322651
SQLE squalene epoxidase 0.0321331
HELZ helicase with zinc finger 0.031774
B2M beta-2-microglobulin 0.0315615
PDE8A phosphodiesterase 8A 0.031359
RLF rearranged L-myc fusion 0.0311741
UBA6 ubiquitin-like modifier activating enzyme 6 0.030892
FAM13A family with sequence similarity 13, member A 0.0308704
LPP LIM domain containing preferred translocation partner in lipoma 0.0307689
USP3 ubiquitin specific peptidase 3 0.0306373
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0306312
ITCH itchy E3 ubiquitin protein ligase 0.0305914
PDIA6 protein disulfide isomerase family A, member 6 0.0305734
TMEM165 transmembrane protein 165 0.0304833
ARRDC3 arrestin domain containing 3 0.0302063
PSD3 pleckstrin and Sec7 domain containing 3 0.0299101
BHLHE40 basic helix-loop-helix family, member e40 0.0295159
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0294626
EFNA5 ephrin-A5 0.0293118
TSC22D2 TSC22 domain family, member 2 0.0290165
MACF1 microtubule-actin crosslinking factor 1 0.0287954
TNIP1 TNFAIP3 interacting protein 1 0.0286936
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0283368
UGCG UDP-glucose ceramide glucosyltransferase 0.0282308
GRB10 growth factor receptor-bound protein 10 0.0281206
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0278723
OGA O-GlcNAcase 0.0274551
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0273517
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0273307
EGFR epidermal growth factor receptor 0.0270541
DOCK7 dedicator of cytokinesis 7 0.0270065
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0269465
RAB1A RAB1A, member RAS oncogene family 0.0269401
ZCCHC7 zinc finger, CCHC domain containing 7 0.0263212
TTC3 tetratricopeptide repeat domain 3 0.0263133
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0258735
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0258433
SNX9 sorting nexin 9 0.0255967
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0254953

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.432916
IGFBP3 insulin-like growth factor binding protein 3 -0.263237
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.17342
FTH1 ferritin, heavy polypeptide 1 -0.106865
COL1A1 collagen, type I, alpha 1 -0.0965433
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0615615
COL1A2 collagen, type I, alpha 2 -0.0504111
LOX lysyl oxidase -0.044224
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0408573
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0380042
TPM4 tropomyosin 4 -0.0368434
TMSB10 thymosin beta 10 -0.0346614
FBN1 fibrillin 1 -0.0321102
VCL vinculin -0.0318618
RPL35A ribosomal protein L35a -0.0313316
OSMR oncostatin M receptor -0.0308657
VIM vimentin -0.0301754
LOC112694756 uncharaterized LOC112694756 -0.0294631
CANX calnexin -0.0292381
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0285384
POSTN periostin, osteoblast specific factor -0.0273706
COL3A1 collagen, type III, alpha 1 -0.0269099
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0265887
TRPS1 trichorhinophalangeal syndrome I -0.0260172
AHNAK AHNAK nucleoprotein -0.0257706
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0243315
PALLD palladin, cytoskeletal associated protein -0.0198008
ASPH aspartate beta-hydroxylase -0.0188171
RRBP1 ribosome binding protein 1 -0.0187857
PDLIM5 PDZ and LIM domain 5 -0.0186527
TPT1 tumor protein, translationally-controlled 1 -0.0184138
LTBP1 latent transforming growth factor beta binding protein 1 -0.0183394
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0182658
HDLBP high density lipoprotein binding protein -0.0181055
HMCN1 hemicentin 1 -0.0179148
SAMD9 sterile alpha motif domain containing 9 -0.0175338
NABP1 nucleic acid binding protein 1 -0.0174746
MAP1B microtubule-associated protein 1B -0.0172375
COL6A1 collagen, type VI, alpha 1 -0.0170801
HLA-C major histocompatibility complex, class I, C -0.01704
PDE4D phosphodiesterase 4D, cAMP-specific -0.0168803
RIGI RNA sensor RIG-I -0.0165568
GANAB glucosidase, alpha; neutral AB -0.0162618
GLIS3 GLIS family zinc finger 3 -0.0161696
COL6A2 collagen, type VI, alpha 2 -0.0157623
IFI16 interferon, gamma-inducible protein 16 -0.0155664
HLA-B major histocompatibility complex, class I, B -0.0149327
CALD1 caldesmon 1 -0.0146339
ARF1 ADP-ribosylation factor 1 -0.0145526
SOD2 superoxide dismutase 2, mitochondrial -0.0144095
EGR1 early growth response 1 -0.0143359
CAVIN1 caveolae associated protein 1 -0.0140941
EEF2 eukaryotic translation elongation factor 2 -0.0140242
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0135861
BSG basigin (Ok blood group) -0.0135386
GNAS GNAS complex locus -0.0134212
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.01316
MX2 MX dynamin-like GTPase 2 -0.0131014
SVIL supervillin -0.013039
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0128646
NREP neuronal regeneration related protein -0.0127636
ZFPM2 zinc finger protein, FOG family member 2 -0.0127194
RPL34 ribosomal protein L34 -0.0126452
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0125596
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0124313
ARCN1 archain 1 -0.0121234
CD44 CD44 molecule (Indian blood group) -0.011981
NRP1 neuropilin 1 -0.0119768
ACTG1 actin gamma 1 -0.011782
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0117343
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.011708
GLIPR1 GLI pathogenesis-related 1 -0.0112726
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.011206
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0111201
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -0.0111131
TMSB4X thymosin beta 4, X-linked -0.0110992
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0110749
GBP1 guanylate binding protein 1, interferon-inducible -0.0110744
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0109885
FLNA filamin A, alpha -0.0109706
LMAN1 lectin, mannose-binding, 1 -0.0109627
TAPBP TAP binding protein (tapasin) -0.01043
SP100 SP100 nuclear antigen -0.0103404
SULF1 sulfatase 1 -0.0103186
NCOA7 nuclear receptor coactivator 7 -0.0102783
LDHA lactate dehydrogenase A -0.0102746
FKBP10 FK506 binding protein 10, 65 kDa -0.010241
ISG15 ISG15 ubiquitin-like modifier -0.0101217
PRSS23 protease, serine, 23 -0.0100946
JAK2 Janus kinase 2 -0.0100878
CPQ carboxypeptidase Q -0.00991255
TENM1 teneurin transmembrane protein 1 -0.0099023
WNT2B wingless-type MMTV integration site family, member 2B -0.00988446
SRPRA SRP receptor subunit alpha -0.00982894
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.00977606
FSCN1 fascin actin-bundling protein 1 -0.00976413
MORF4L2 mortality factor 4 like 2 -0.00972129
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.00967793
PXDN peroxidasin -0.00967437
RFTN1 raftlin, lipid raft linker 1 -0.0096705