Ornidazole_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.207979
LRMDA leucine rich melanocyte differentiation associated 0.109292
APOB apolipoprotein B 0.103896
FNDC3B fibronectin type III domain containing 3B 0.103452
FN1 fibronectin 1 0.102618
AFDN afadin, adherens junction formation factor 0.0961821
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0951028
SAMD4A sterile alpha motif domain containing 4A 0.0930297
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0876056
VEGFA vascular endothelial growth factor A 0.0747598
MYH9 myosin, heavy chain 9, non-muscle 0.0735707
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0728128
ELL2 elongation factor, RNA polymerase II, 2 0.0706833
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0678496
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.067566
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0650068
MACF1 microtubule-actin crosslinking factor 1 0.0535319
DSCAM Down syndrome cell adhesion molecule 0.0516282
BHLHE40 basic helix-loop-helix family, member e40 0.0495604
TNS1 tensin 1 0.0494148
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0492455
SMAD3 SMAD family member 3 0.0455468
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0454136
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0451852
EPAS1 endothelial PAS domain protein 1 0.0449332
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0442504
TRIO trio Rho guanine nucleotide exchange factor 0.0437975
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0431421
RBM39 RNA binding motif protein 39 0.042609
RPL3 ribosomal protein L3 0.0422011
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0421247
ATXN1 ataxin 1 0.041705
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0416201
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0415213
C3 complement component 3 0.0405981
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0400429
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0399878
CFB complement factor B 0.0390128
DENND4A DENN/MADD domain containing 4A 0.0374872
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0374267
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0373815
ZMIZ1 zinc finger, MIZ-type containing 1 0.0367538
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0363428
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0356553
ARHGAP9 Rho GTPase activating protein 9 0.0343959
RB1CC1 RB1-inducible coiled-coil 1 0.0341473
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0336915
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0336826
SESTD1 SEC14 and spectrin domains 1 0.0335237
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0327485
ZFAND3 zinc finger, AN1-type domain 3 0.0326911
NKD1 naked cuticle homolog 1 (Drosophila) 0.0325001
PLEC plectin 0.0318286
NRIP1 nuclear receptor interacting protein 1 0.0317068
EEF2 eukaryotic translation elongation factor 2 0.0315554
MALT1 MALT1 paracaspase 0.0315154
FAT1 FAT atypical cadherin 1 0.0307908
CAMTA1 calmodulin binding transcription activator 1 0.0306147
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0302636
MSI2 musashi RNA-binding protein 2 0.0298569
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0297996
IGF2R insulin-like growth factor 2 receptor 0.0296291
PTPRM protein tyrosine phosphatase, receptor type, M 0.0294758
FMNL2 formin-like 2 0.0293566
FLNB filamin B, beta 0.0292686
IGF1R insulin-like growth factor 1 receptor 0.0290684
PRELID2 PRELI domain containing 2 0.0290296
CCNY cyclin Y 0.0289707
DSPP dentin sialophosphoprotein 0.0287293
PUM2 pumilio RNA-binding family member 2 0.0286639
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0283029
DOCK4 dedicator of cytokinesis 4 0.0281423
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0279491
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0276816
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0271646
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0271579
KRT8 keratin 8, type II 0.0269229
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0265235
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264998
CEP250 centrosomal protein 250kDa 0.0260813
ZEB1 zinc finger E-box binding homeobox 1 0.0256364
WAC WW domain containing adaptor with coiled-coil 0.0256251
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0255408
IQSEC1 IQ motif and Sec7 domain 1 0.025222
ABI1 abl-interactor 1 0.0250121
JAK1 Janus kinase 1 0.0249569
WNK1 WNK lysine deficient protein kinase 1 0.0248844
EML4 echinoderm microtubule associated protein like 4 0.0247328
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024727
DENND1A DENN/MADD domain containing 1A 0.0246613
PTK2 protein tyrosine kinase 2 0.0241662
WTAP Wilms tumor 1 associated protein 0.0240071
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0239088
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0237781
TBC1D22A TBC1 domain family, member 22A 0.0237125
IL4R interleukin 4 receptor 0.0232545
CYTH1 cytohesin 1 0.0231757
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0231125
WDFY2 WD repeat and FYVE domain containing 2 0.0229309
KDM7A lysine (K)-specific demethylase 7A 0.0229075

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.482465
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.188208
MT2A metallothionein 2A -0.143756
IGF2 insulin-like growth factor 2 -0.130548
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114106
TPT1 tumor protein, translationally-controlled 1 -0.0974835
FTL ferritin, light polypeptide -0.0958183
AKAP12 A kinase (PRKA) anchor protein 12 -0.0912175
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0905086
RPS6 ribosomal protein S6 -0.0859154
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0852356
APOA2 apolipoprotein A-II -0.0802318
AHSG alpha-2-HS-glycoprotein -0.0703054
TMSB10 thymosin beta 10 -0.0668436
ENO1 enolase 1, (alpha) -0.0627408
RPS8 ribosomal protein S8 -0.0538084
RPL35A ribosomal protein L35a -0.0530506
HMGA1 high mobility group AT-hook 1 -0.0523264
RPLP2 ribosomal protein, large, P2 -0.0484871
RPS24 ribosomal protein S24 -0.0468194
RPLP1 ribosomal protein, large, P1 -0.0463979
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0415529
RPL34 ribosomal protein L34 -0.0414465
RPS19 ribosomal protein S19 -0.0404371
CP ceruloplasmin (ferroxidase) -0.0385586
GPC3 glypican 3 -0.0354838
RPL37A ribosomal protein L37a -0.0354407
ISG15 ISG15 ubiquitin-like modifier -0.0341074
RPLP0 ribosomal protein, large, P0 -0.034014
RPL31 ribosomal protein L31 -0.0335363
RPS14 ribosomal protein S14 -0.0335317
RPS29 ribosomal protein S29 -0.0332569
RPS5 ribosomal protein S5 -0.0330215
IFI6 interferon, alpha-inducible protein 6 -0.0327381
RPL12 ribosomal protein L12 -0.0326333
APOA1 apolipoprotein A-I -0.032558
AMBP alpha-1-microglobulin/bikunin precursor -0.0325547
PLIN2 perilipin 2 -0.0323874
RPL11 ribosomal protein L11 -0.0321704
IFITM1 interferon induced transmembrane protein 1 -0.031959
PTMA prothymosin, alpha -0.031723
RPS13 ribosomal protein S13 -0.0313517
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0307308
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0302467
S100A9 S100 calcium binding protein A9 -0.0292821
RPL23 ribosomal protein L23 -0.028178
RPL32 ribosomal protein L32 -0.0281067
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0279244
GNAS GNAS complex locus -0.0276391
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.027136
IER3 immediate early response 3 -0.0258279
UBC ubiquitin C -0.0251416
RPS21 ribosomal protein S21 -0.0245794
TM4SF1 transmembrane 4 L six family member 1 -0.0243762
CPE carboxypeptidase E -0.0242038
LYZ lysozyme -0.0239443
RPS27A ribosomal protein S27a -0.023855
RPS23 ribosomal protein S23 -0.0237656
HLA-A major histocompatibility complex, class I, A -0.0235126
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.023431
FBF1 Fas (TNFRSF6) binding factor 1 -0.023266
RPS25 ribosomal protein S25 -0.0231805
RPS11 ribosomal protein S11 -0.0230591
FTH1 ferritin, heavy polypeptide 1 -0.0228816
EIF5B eukaryotic translation initiation factor 5B -0.0222316
RPL19 ribosomal protein L19 -0.0221924
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0218475
RPL28 ribosomal protein L28 -0.0218458
RPL27A ribosomal protein L27a -0.0217619
JUN jun proto-oncogene -0.0216525
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.021616
APOE apolipoprotein E -0.0215772
RPL9 ribosomal protein L9 -0.0212275
IFITM3 interferon induced transmembrane protein 3 -0.0207565
RPL26 ribosomal protein L26 -0.0207434
CST3 cystatin C -0.0207228
RPL36 ribosomal protein L36 -0.0205511
ATP5F1E ATP synthase F1 subunit epsilon -0.020427
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0200558
PCBP2 poly(rC) binding protein 2 -0.0195972
PDIA3 protein disulfide isomerase family A, member 3 -0.0192971
LDHA lactate dehydrogenase A -0.0191924
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0191085
RPL8 ribosomal protein L8 -0.0191055
MX2 MX dynamin-like GTPase 2 -0.018854
RPS12 ribosomal protein S12 -0.0188271
ACTG1 actin gamma 1 -0.0187604
PFN1 profilin 1 -0.0186274
TPM4 tropomyosin 4 -0.0185031
VIM vimentin -0.0184649
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0183677
CTSD cathepsin D -0.0183056
POTEF POTE ankyrin domain family, member F -0.0183041
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0182441
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0180795
CYB5R3 cytochrome b5 reductase 3 -0.0178469
BSG basigin (Ok blood group) -0.0178013
TRAM1 translocation associated membrane protein 1 -0.0176481
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0174303
EIF1 eukaryotic translation initiation factor 1 -0.0174249