Ornidazole_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.145486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.116677
KRT18 keratin 18, type I 0.107997
EEF2 eukaryotic translation elongation factor 2 0.0844848
EREG epiregulin 0.0792561
FTH1 ferritin, heavy polypeptide 1 0.0773524
FAM13A family with sequence similarity 13, member A 0.0712708
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0689404
PDIA4 protein disulfide isomerase family A, member 4 0.0688573
DSCAM Down syndrome cell adhesion molecule 0.0674551
NDRG1 N-myc downstream regulated 1 0.0663533
OGA O-GlcNAcase 0.0598484
H1-0 H1.0 linker histone 0.0565241
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.053601
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.052506
KRT8 keratin 8, type II 0.0471464
GOLGA4 golgin A4 0.0467857
CALR calreticulin 0.0459026
PRELID2 PRELI domain containing 2 0.0454691
PLEC plectin 0.0446364
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0431812
DSPP dentin sialophosphoprotein 0.0426338
MYH9 myosin, heavy chain 9, non-muscle 0.0424671
MBNL2 muscleblind-like splicing regulator 2 0.0414976
KDM3A lysine (K)-specific demethylase 3A 0.0413239
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0406741
RNF43 ring finger protein 43 0.0386835
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0376246
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0369574
ZFAND3 zinc finger, AN1-type domain 3 0.036441
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0362974
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.036281
UBA6 ubiquitin-like modifier activating enzyme 6 0.0361036
SEC31A SEC31 homolog A (S. cerevisiae) 0.0340449
DDIT4 DNA-damage-inducible transcript 4 0.0331508
MACF1 microtubule-actin crosslinking factor 1 0.0328748
LOC112694756 uncharaterized LOC112694756 0.0319418
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0311549
CLTC clathrin, heavy chain (Hc) 0.0308426
WDR45B WD repeat domain 45B 0.0298996
FAT1 FAT atypical cadherin 1 0.0296176
ANKRD11 ankyrin repeat domain 11 0.0293474
HDLBP high density lipoprotein binding protein 0.0283972
VEGFA vascular endothelial growth factor A 0.0282602
ERRFI1 ERBB receptor feedback inhibitor 1 0.0280694
CD2AP CD2-associated protein 0.0276544
PLAUR plasminogen activator, urokinase receptor 0.0275267
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0273932
ZFC3H1 zinc finger, C3H1-type containing 0.0272584
BTBD9 BTB (POZ) domain containing 9 0.0271548
NCOR1 nuclear receptor corepressor 1 0.0267935
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0267515
RAB1A RAB1A, member RAS oncogene family 0.0265711
EIF4A2 eukaryotic translation initiation factor 4A2 0.0259647
ESYT2 extended synaptotagmin-like protein 2 0.0258667
CEMIP cell migration inducing protein, hyaluronan binding 0.0257141
COPB1 coatomer protein complex, subunit beta 1 0.0255403
COPA coatomer protein complex, subunit alpha 0.0254621
SUCO SUN domain containing ossification factor 0.0254607
CANX calnexin 0.0251132
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0250632
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0250436
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0250092
AREG amphiregulin 0.0249981
RBM39 RNA binding motif protein 39 0.0247991
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0245386
CCNY cyclin Y 0.0244051
DERA deoxyribose-phosphate aldolase (putative) 0.0241442
KLF5 Kruppel-like factor 5 (intestinal) 0.0240969
TPM3 tropomyosin 3 0.0240349
TM9SF2 transmembrane 9 superfamily member 2 0.0240056
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0238042
MED13L mediator complex subunit 13-like 0.0235719
HELZ helicase with zinc finger 0.0234254
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0231713
CSNK1A1 casein kinase 1, alpha 1 0.0230389
SEC24D SEC24 family member D 0.0230168
MON2 MON2 homolog (S. cerevisiae) 0.0229257
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0228587
MCTP2 multiple C2 domains, transmembrane 2 0.0227403
TMF1 TATA element modulatory factor 1 0.0227196
RAB6A RAB6A, member RAS oncogene family 0.0226587
GLCE glucuronic acid epimerase 0.0226342
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0221357
CDK19 cyclin-dependent kinase 19 0.0218643
GSK3B glycogen synthase kinase 3 beta 0.0218524
SETD5 SET domain containing 5 0.0215432
TRA2A transformer 2 alpha homolog (Drosophila) 0.0214821
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0214738
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0210123
DNM2 dynamin 2 0.020984
ACBD3 acyl-CoA binding domain containing 3 0.0209369
GOLGA2 golgin A2 0.0209314
TXNIP thioredoxin interacting protein 0.0208927
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0204831
SRP54 signal recognition particle 54kDa 0.0204499
MXI1 MAX interactor 1, dimerization protein 0.0202291
YME1L1 YME1-like 1 ATPase 0.0202189
OSBP oxysterol binding protein 0.0202124
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.020193

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.229252
NPSR1 neuropeptide S receptor 1 -0.185631
MUC6 mucin 6, oligomeric mucus/gel-forming -0.114511
RPS6 ribosomal protein S6 -0.113951
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.10707
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0956636
PTMA prothymosin, alpha -0.087437
RPL35A ribosomal protein L35a -0.0730081
GMDS GDP-mannose 4,6-dehydratase -0.0715885
TPT1 tumor protein, translationally-controlled 1 -0.067273
NALF1 NALCN channel auxiliary factor 1 -0.0667252
ALCAM activated leukocyte cell adhesion molecule -0.0658672
RPS19 ribosomal protein S19 -0.0635872
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0631584
MYO1E myosin IE -0.0614178
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0598749
RPS8 ribosomal protein S8 -0.0586043
LOC102724023 ES1 protein homolog, mitochondrial -0.0565452
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0555337
RPL34 ribosomal protein L34 -0.0545628
RPLP1 ribosomal protein, large, P1 -0.0517837
GPHN gephyrin -0.0508933
ANTXR2 anthrax toxin receptor 2 -0.0502916
SOX4 SRY (sex determining region Y)-box 4 -0.0484621
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0466634
GREB1L growth regulation by estrogen in breast cancer-like -0.0453851
FHIT fragile histidine triad -0.0451299
TFF1 trefoil factor 1 -0.0451167
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0434111
S100A6 S100 calcium binding protein A6 -0.0432872
MT2A metallothionein 2A -0.043044
RPLP2 ribosomal protein, large, P2 -0.0426574
RPL23 ribosomal protein L23 -0.0426184
PDE4D phosphodiesterase 4D, cAMP-specific -0.0424715
PTPRK protein tyrosine phosphatase, receptor type, K -0.0423951
TFF3 trefoil factor 3 (intestinal) -0.0414796
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0399965
RPS25 ribosomal protein S25 -0.039661
ACTG1 actin gamma 1 -0.0394667
RPL31 ribosomal protein L31 -0.0381387
RPL36 ribosomal protein L36 -0.037435
RPS21 ribosomal protein S21 -0.0372661
FTL ferritin, light polypeptide -0.0371333
RPS29 ribosomal protein S29 -0.0363309
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0352848
POTEF POTE ankyrin domain family, member F -0.0349336
SAMD5 sterile alpha motif domain containing 5 -0.0345557
CCND1 cyclin D1 -0.0342491
RPS14 ribosomal protein S14 -0.0334959
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0325903
RNF217 ring finger protein 217 -0.032134
ONECUT3 one cut homeobox 3 -0.031767
HMGA1 high mobility group AT-hook 1 -0.0317024
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0313902
SH3D19 SH3 domain containing 19 -0.0312175
CCSER1 coiled-coil serine-rich protein 1 -0.0310036
RPL8 ribosomal protein L8 -0.0297593
RPS23 ribosomal protein S23 -0.0294755
RPL37A ribosomal protein L37a -0.0293605
RPS27 ribosomal protein S27 -0.0292119
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0289471
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0288815
VCL vinculin -0.0288558
MGST1 microsomal glutathione S-transferase 1 -0.0281904
EGFR epidermal growth factor receptor -0.0279556
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0277837
DIAPH2 diaphanous-related formin 2 -0.0276256
RPL5 ribosomal protein L5 -0.0275156
HMGB1 high mobility group box 1 -0.0273044
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0271163
PFN1 profilin 1 -0.0270636
MECOM MDS1 and EVI1 complex locus -0.0265145
EPHB2 EPH receptor B2 -0.0264177
EIF5B eukaryotic translation initiation factor 5B -0.0261541
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0260859
MAML3 mastermind-like 3 (Drosophila) -0.0256432
SLC35F3 solute carrier family 35, member F3 -0.025561
CALB1 calbindin 1, 28kDa -0.0255171
LSAMP limbic system-associated membrane protein -0.0252601
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0252496
LGALS3 lectin, galactoside-binding, soluble, 3 -0.025188
CCDC91 coiled-coil domain containing 91 -0.0251093
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0250056
RAD51B RAD51 paralog B -0.0247484
RPL9 ribosomal protein L9 -0.0245188
ABHD2 abhydrolase domain containing 2 -0.0243291
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0242946
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.024266
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0242544
RPL27A ribosomal protein L27a -0.0241467
PA2G4 proliferation-associated 2G4, 38kDa -0.0235963
ZBTB20 zinc finger and BTB domain containing 20 -0.023553
GTF2IRD1 GTF2I repeat domain containing 1 -0.0234236
PSD3 pleckstrin and Sec7 domain containing 3 -0.023335
RPL36A ribosomal protein L36a -0.0230257
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0227946
RPS16 ribosomal protein S16 -0.0227911
PTPRG protein tyrosine phosphatase, receptor type, G -0.0226951
RPS24 ribosomal protein S24 -0.0222742
S100A10 S100 calcium binding protein A10 -0.0221816