Ornidazole_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.210929
ERRFI1 ERBB receptor feedback inhibitor 1 0.179944
ELL2 elongation factor, RNA polymerase II, 2 0.157184
KRT17 keratin 17, type I 0.122725
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.111189
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108951
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0988415
FAM13A family with sequence similarity 13, member A 0.0951132
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0917672
OGA O-GlcNAcase 0.0765663
BRD2 bromodomain containing 2 0.0756981
RB1CC1 RB1-inducible coiled-coil 1 0.0710872
ANXA1 annexin A1 0.0696635
TSC22D2 TSC22 domain family, member 2 0.0680347
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0675949
RAB7A RAB7A, member RAS oncogene family 0.065202
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0639486
ANLN anillin, actin binding protein 0.0616792
KMT2E lysine (K)-specific methyltransferase 2E 0.0598048
SETD5 SET domain containing 5 0.0596235
JMJD1C jumonji domain containing 1C 0.0585805
ANKRD11 ankyrin repeat domain 11 0.057879
FTH1 ferritin, heavy polypeptide 1 0.057785
CSNK1A1 casein kinase 1, alpha 1 0.0568758
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0566219
RPS6 ribosomal protein S6 0.0566093
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0565952
GRB10 growth factor receptor-bound protein 10 0.0561187
RUNX1 runt-related transcription factor 1 0.0557064
HOOK2 hook microtubule-tethering protein 2 0.0547114
SMAD3 SMAD family member 3 0.0545723
IFRD1 interferon-related developmental regulator 1 0.0540422
KDM3A lysine (K)-specific demethylase 3A 0.0529118
FXR1 fragile X mental retardation, autosomal homolog 1 0.0526433
ADAM17 ADAM metallopeptidase domain 17 0.0522307
SEPTIN2 septin 2 0.051982
NAV2 neuron navigator 2 0.0519713
PABPC1 poly(A) binding protein, cytoplasmic 1 0.051901
TOP1 topoisomerase (DNA) I 0.0500004
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0499864
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0496058
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0493959
FLNB filamin B, beta 0.0485888
KTN1 kinectin 1 (kinesin receptor) 0.0481019
ZFAND3 zinc finger, AN1-type domain 3 0.0469277
BAIAP2L1 BAI1-associated protein 2-like 1 0.0451672
USP3 ubiquitin specific peptidase 3 0.0441842
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0440443
FTL ferritin, light polypeptide 0.0434736
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0434659
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.043307
INHBA inhibin, beta A 0.0429788
PDIA3 protein disulfide isomerase family A, member 3 0.0428807
OXR1 oxidation resistance 1 0.0425084
RAP1B RAP1B, member of RAS oncogene family 0.0425012
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0421481
NGLY1 N-glycanase 1 0.0420151
HMGA2 high mobility group AT-hook 2 0.0412843
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0411955
SBF2 SET binding factor 2 0.040345
TFG TRK-fused gene 0.0396537
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0392201
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0387008
KMT2A lysine (K)-specific methyltransferase 2A 0.0386917
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.0381041
TRA2A transformer 2 alpha homolog (Drosophila) 0.0378711
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0378508
ESYT2 extended synaptotagmin-like protein 2 0.0376787
HELZ helicase with zinc finger 0.0372906
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0372878
PTGES2 prostaglandin E synthase 2 0.0371739
FNBP1L formin binding protein 1-like 0.0367542
TP53BP2 tumor protein p53 binding protein 2 0.0365249
ZNF292 zinc finger protein 292 0.0358061
DTNA dystrobrevin, alpha 0.0350706
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0349596
CCNY cyclin Y 0.0349361
CANX calnexin 0.0347287
GOLGA4 golgin A4 0.0346782
PDIA6 protein disulfide isomerase family A, member 6 0.0346676
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0339658
PDLIM5 PDZ and LIM domain 5 0.0337928
NAP1L1 nucleosome assembly protein 1-like 1 0.0330767
NCOR1 nuclear receptor corepressor 1 0.0330745
SEPTIN7 septin 7 0.0329487
FMNL2 formin-like 2 0.0328616
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0324324
RICTOR RPTOR independent companion of MTOR, complex 2 0.0323211
RPS12 ribosomal protein S12 0.0319534
RPL12 ribosomal protein L12 0.0317408
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0315191
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.031467
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0314454
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0312942
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0312399
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0310901
AKAP9 A kinase (PRKA) anchor protein 9 0.0308518
CDC73 cell division cycle 73 0.0305653
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0305265
APLP2 amyloid beta (A4) precursor-like protein 2 0.0303847

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.160171
IFIH1 interferon induced with helicase C domain 1 -0.155263
MYO1E myosin IE -0.146638
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.101075
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0893643
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.089324
FNDC3A fibronectin type III domain containing 3A -0.0875395
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0772673
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0771299
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0723054
RAD51B RAD51 paralog B -0.0704111
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0701934
SOX4 SRY (sex determining region Y)-box 4 -0.0700729
SMYD3 SET and MYND domain containing 3 -0.0691829
FOXP1 forkhead box P1 -0.0638313
SPAG9 sperm associated antigen 9 -0.063055
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0628183
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0619473
ABHD17C abhydrolase domain containing 17C -0.060665
OASL 2'-5'-oligoadenylate synthetase-like -0.0582017
WSB1 WD repeat and SOCS box containing 1 -0.0580974
NALF1 NALCN channel auxiliary factor 1 -0.0577431
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0574222
PTPRD protein tyrosine phosphatase, receptor type, D -0.0571753
STK17A serine/threonine kinase 17a -0.0566207
MAML3 mastermind-like 3 (Drosophila) -0.0565215
SAMD4A sterile alpha motif domain containing 4A -0.0563109
MRTFA myocardin related transcription factor A -0.0552993
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0551979
RIGI RNA sensor RIG-I -0.0548474
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0544636
OSMR oncostatin M receptor -0.0542555
FRMD5 FERM domain containing 5 -0.0534096
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) -0.0529649
LAMC2 laminin, gamma 2 -0.0527135
EFNA5 ephrin-A5 -0.0519509
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0516178
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0510428
ARHGAP5 Rho GTPase activating protein 5 -0.0495678
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0493972
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0489059
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0480067
FAT1 FAT atypical cadherin 1 -0.047732
ATOSA atos homolog A -0.0473216
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0468498
SLMAP sarcolemma associated protein -0.0466102
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0459031
MED13 mediator complex subunit 13 -0.0452954
RNF213 ring finger protein 213 -0.0452789
TXNRD1 thioredoxin reductase 1 -0.0452659
RBM47 RNA binding motif protein 47 -0.0448024
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0442976
OXSR1 oxidative stress responsive 1 -0.043522
ZNFX1 zinc finger, NFX1-type containing 1 -0.0434414
LIMCH1 LIM and calponin homology domains 1 -0.0432497
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0432232
BPTF bromodomain PHD finger transcription factor -0.0430059
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0429607
EGFR epidermal growth factor receptor -0.0428915
SH3KBP1 SH3-domain kinase binding protein 1 -0.042285
SLC38A1 solute carrier family 38, member 1 -0.0418007
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0417978
KATNBL1 katanin p80 subunit B-like 1 -0.0415394
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0412254
FTO fat mass and obesity associated -0.0412145
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0406952
CEMIP cell migration inducing protein, hyaluronan binding -0.0405774
SVIL supervillin -0.0403532
AKAP12 A kinase (PRKA) anchor protein 12 -0.0400651
SEC31A SEC31 homolog A (S. cerevisiae) -0.0400212
CUX1 cut-like homeobox 1 -0.0398534
THSD4 thrombospondin, type I, domain containing 4 -0.0396056
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0394478
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0388576
CDK13 cyclin-dependent kinase 13 -0.038471
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.038346
POTEF POTE ankyrin domain family, member F -0.0383231
PAPOLA poly(A) polymerase alpha -0.0382966
FCHSD2 FCH and double SH3 domains 2 -0.0382087
TMEM87A transmembrane protein 87A -0.0375488
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0369001
SYT1 synaptotagmin I -0.0368191
VDAC1 voltage-dependent anion channel 1 -0.0367995
LPP LIM domain containing preferred translocation partner in lipoma -0.0361587
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0361047
MORC3 MORC family CW-type zinc finger 3 -0.0353824
MEF2A myocyte enhancer factor 2A -0.0352443
DOCK5 dedicator of cytokinesis 5 -0.0351421
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0350738
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0349915
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0348831
PATJ PATJ crumbs cell polarity complex component -0.0346186
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0343827
B2M beta-2-microglobulin -0.0343266
IGF1R insulin-like growth factor 1 receptor -0.0341729
NRG1 neuregulin 1 -0.0341612
AGO2 argonaute RISC catalytic component 2 -0.03405
ANXA2 annexin A2 -0.0340354
IGF2 insulin-like growth factor 2 -0.033982
VCL vinculin -0.0339532