Ornidazole_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.210107
FNDC3B fibronectin type III domain containing 3B 0.178464
NAMPT nicotinamide phosphoribosyltransferase 0.16388
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.143525
ZNF292 zinc finger protein 292 0.13671
UGCG UDP-glucose ceramide glucosyltransferase 0.13116
PDE10A phosphodiesterase 10A 0.107191
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.101379
CADM1 cell adhesion molecule 1 0.0931563
ELL2 elongation factor, RNA polymerase II, 2 0.0887395
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0862236
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0856127
MXI1 MAX interactor 1, dimerization protein 0.0781369
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0764997
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0751326
NAV2 neuron navigator 2 0.0724268
FMNL2 formin-like 2 0.0723304
PGK1 phosphoglycerate kinase 1 0.0714731
PRELID2 PRELI domain containing 2 0.0707489
UBA6 ubiquitin-like modifier activating enzyme 6 0.0691231
NDRG1 N-myc downstream regulated 1 0.0677818
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0670573
GOLGA4 golgin A4 0.0664194
MYH9 myosin, heavy chain 9, non-muscle 0.0650702
HELZ helicase with zinc finger 0.0635755
ATP13A3 ATPase type 13A3 0.0607855
OGA O-GlcNAcase 0.0593668
FNIP1 folliculin interacting protein 1 0.0586766
RPS12 ribosomal protein S12 0.0567711
TSC22D2 TSC22 domain family, member 2 0.0565834
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0556874
B2M beta-2-microglobulin 0.0531713
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.053067
VEGFA vascular endothelial growth factor A 0.0510855
PTMA prothymosin, alpha 0.0505969
KMT2E lysine (K)-specific methyltransferase 2E 0.0501717
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0489102
PHF21A PHD finger protein 21A 0.0480045
FLNB filamin B, beta 0.047802
SDK1 sidekick cell adhesion molecule 1 0.047401
FLOT1 flotillin 1 0.0472611
NPEPPS aminopeptidase puromycin sensitive 0.0471891
PNISR PNN-interacting serine/arginine-rich protein 0.046869
RB1CC1 RB1-inducible coiled-coil 1 0.0465085
ZMIZ1 zinc finger, MIZ-type containing 1 0.04645
ESYT2 extended synaptotagmin-like protein 2 0.0464213
EPS8 epidermal growth factor receptor pathway substrate 8 0.0459598
JMJD1C jumonji domain containing 1C 0.0454874
MYOF myoferlin 0.0439586
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0438813
SETD5 SET domain containing 5 0.043092
FOXO3 forkhead box O3 0.0427375
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0421987
NGLY1 N-glycanase 1 0.0416695
PTBP3 polypyrimidine tract binding protein 3 0.0416499
DST dystonin 0.0414763
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0407424
SNX9 sorting nexin 9 0.0403939
KDM2A lysine (K)-specific demethylase 2A 0.0403306
FAM13A family with sequence similarity 13, member A 0.0401419
LCORL ligand dependent nuclear receptor corepressor-like 0.0400517
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0393837
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0387695
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0387618
DLG1 discs, large homolog 1 (Drosophila) 0.03873
PPARD peroxisome proliferator-activated receptor delta 0.0381481
KDM6A lysine (K)-specific demethylase 6A 0.0376455
STC1 stanniocalcin 1 0.0374627
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.036824
WSB1 WD repeat and SOCS box containing 1 0.0365214
YEATS2 YEATS domain containing 2 0.0360098
AKAP12 A kinase (PRKA) anchor protein 12 0.035934
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0359169
ARFGEF3 ARFGEF family member 3 0.0355545
KTN1 kinectin 1 (kinesin receptor) 0.0355139
TENT5A terminal nucleotidyltransferase 5A 0.0355036
NT5C2 5'-nucleotidase, cytosolic II 0.0352708
ARRDC3 arrestin domain containing 3 0.0348165
RPS8 ribosomal protein S8 0.0345696
ANKRD11 ankyrin repeat domain 11 0.0345215
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0342915
RUNX1 runt-related transcription factor 1 0.0342632
ERRFI1 ERBB receptor feedback inhibitor 1 0.0334133
COPA coatomer protein complex, subunit alpha 0.0333023
MMP12 matrix metallopeptidase 12 0.0332371
CDK19 cyclin-dependent kinase 19 0.0331112
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0330948
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0329524
RAB1A RAB1A, member RAS oncogene family 0.0327075
UBE2H ubiquitin-conjugating enzyme E2H 0.0326851
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0322898
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321494
WTAP Wilms tumor 1 associated protein 0.032107
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0319392
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0313118
SPAG9 sperm associated antigen 9 0.031264
SBF2 SET binding factor 2 0.0309942
CENPF centromere protein F, 350/400kDa 0.030893
USP37 ubiquitin specific peptidase 37 0.03083
RAB6A RAB6A, member RAS oncogene family 0.0306533

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.159415
VCL vinculin -0.133817
SOD2 superoxide dismutase 2, mitochondrial -0.133173
FN1 fibronectin 1 -0.13076
GLIS3 GLIS family zinc finger 3 -0.110034
BICC1 BicC family RNA binding protein 1 -0.0832412
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0824091
NABP1 nucleic acid binding protein 1 -0.067685
LOC112694756 uncharaterized LOC112694756 -0.0498911
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0485352
EGR1 early growth response 1 -0.0477442
AHNAK AHNAK nucleoprotein -0.0474095
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0464422
IGFBP3 insulin-like growth factor binding protein 3 -0.0452873
RIGI RNA sensor RIG-I -0.0439614
HMGA2 high mobility group AT-hook 2 -0.0428415
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0416588
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0403425
RNF213 ring finger protein 213 -0.0402919
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0397474
EEF2 eukaryotic translation elongation factor 2 -0.0389767
PALLD palladin, cytoskeletal associated protein -0.0369635
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0348465
GPC6 glypican 6 -0.0342489
THBS1 thrombospondin 1 -0.0331677
ZBTB38 zinc finger and BTB domain containing 38 -0.0326219
SLC38A2 solute carrier family 38, member 2 -0.0321126
EXT1 exostosin glycosyltransferase 1 -0.0299002
HLA-C major histocompatibility complex, class I, C -0.0297295
HLA-A major histocompatibility complex, class I, A -0.0291345
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0288461
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0278699
NCOA7 nuclear receptor coactivator 7 -0.0278026
PALM2AKAP2 PALM2 and AKAP2 fusion -0.027162
IFI16 interferon, gamma-inducible protein 16 -0.0267693
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0262693
THBS2 thrombospondin 2 -0.0259504
FLNA filamin A, alpha -0.0256124
CTSD cathepsin D -0.0255826
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0247684
NTN4 netrin 4 -0.0246688
TUT7 terminal uridylyl transferase 7 -0.0244523
LOX lysyl oxidase -0.0241037
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0233866
PMP22 peripheral myelin protein 22 -0.0231197
HLA-E major histocompatibility complex, class I, E -0.0224336
ACTG1 actin gamma 1 -0.0218953
VMP1 vacuole membrane protein 1 -0.02163
INTS6 integrator complex subunit 6 -0.0214901
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0214892
EHBP1 EH domain binding protein 1 -0.0213302
GOPC golgi-associated PDZ and coiled-coil motif containing -0.0211644
OSMR oncostatin M receptor -0.0207399
TNNC1 troponin C type 1 (slow) -0.0207021
TRIM55 tripartite motif containing 55 -0.0206899
EIF1 eukaryotic translation initiation factor 1 -0.0202776
SH3RF2 SH3 domain containing ring finger 2 -0.0201643
XAF1 XIAP associated factor 1 -0.0193368
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0192861
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0191492
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0189553
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0189158
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0188509
SMAD2 SMAD family member 2 -0.0186119
COL1A2 collagen, type I, alpha 2 -0.0184581
GLIPR1 GLI pathogenesis-related 1 -0.0183635
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0183417
SVIL supervillin -0.0182213
MX1 MX dynamin-like GTPase 1 -0.0182175
COL5A1 collagen, type V, alpha 1 -0.0180565
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0180061
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0176358
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0176078
FAM20C family with sequence similarity 20, member C -0.0173483
PDLIM5 PDZ and LIM domain 5 -0.0173395
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0170012
CREB5 cAMP responsive element binding protein 5 -0.0169562
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.016824
KYNU kynureninase -0.0167169
EPAS1 endothelial PAS domain protein 1 -0.0166717
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0164882
CDK17 cyclin-dependent kinase 17 -0.0164869
REEP3 receptor accessory protein 3 -0.0162807
BCAR3 breast cancer anti-estrogen resistance 3 -0.0161939
FILIP1L filamin A interacting protein 1-like -0.0158784
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0158364
TENM2 teneurin transmembrane protein 2 -0.0157858
GBP1 guanylate binding protein 1, interferon-inducible -0.0156818
KLF12 Kruppel-like factor 12 -0.0154496
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0152665
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.015213
ANXA2 annexin A2 -0.0151663
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0151299
SLC38A1 solute carrier family 38, member 1 -0.0150394
GOLGA3 golgin A3 -0.0150143
STK17A serine/threonine kinase 17a -0.0149891
CAVIN1 caveolae associated protein 1 -0.0147614
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0147146
RAB22A RAB22A, member RAS oncogene family -0.0147079
SAMD9 sterile alpha motif domain containing 9 -0.0144145