Ornidazole_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.296635
MYH9 myosin, heavy chain 9, non-muscle 0.0865581
TRIO trio Rho guanine nucleotide exchange factor 0.0838582
HDAC9 histone deacetylase 9 0.0786177
LIMS1 LIM and senescent cell antigen-like domains 1 0.0777775
ERRFI1 ERBB receptor feedback inhibitor 1 0.0773671
FAM13A family with sequence similarity 13, member A 0.0733789
CDH13 cadherin 13 0.0716548
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0660804
AKAP12 A kinase (PRKA) anchor protein 12 0.0648771
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0636879
NAV2 neuron navigator 2 0.0611489
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0607565
CXCL8 chemokine (C-X-C motif) ligand 8 0.0599989
PDIA6 protein disulfide isomerase family A, member 6 0.058257
MYOF myoferlin 0.0568824
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0548967
RTN4 reticulon 4 0.0512753
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0492927
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0489197
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0488315
FN1 fibronectin 1 0.0482945
PDE4D phosphodiesterase 4D, cAMP-specific 0.0462469
CDC27 cell division cycle 27 0.0449779
MTPN myotrophin 0.0444356
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0443552
TOP1 topoisomerase (DNA) I 0.0440033
ANLN anillin, actin binding protein 0.0434678
UGCG UDP-glucose ceramide glucosyltransferase 0.042827
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.042815
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0427431
DIAPH3 diaphanous-related formin 3 0.0427021
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0425532
UBA6 ubiquitin-like modifier activating enzyme 6 0.0423201
PTPRM protein tyrosine phosphatase, receptor type, M 0.0415146
UBC ubiquitin C 0.0408131
COL5A2 collagen, type V, alpha 2 0.0406099
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0401629
N4BP2L2 NEDD4 binding protein 2-like 2 0.0401468
WWOX WW domain containing oxidoreductase 0.0401293
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0395676
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0394473
WDFY2 WD repeat and FYVE domain containing 2 0.0388936
TIMP3 TIMP metallopeptidase inhibitor 3 0.0386944
PDIA4 protein disulfide isomerase family A, member 4 0.0384957
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.038314
EGFR epidermal growth factor receptor 0.0380857
RPL3 ribosomal protein L3 0.0380621
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0369907
ASPH aspartate beta-hydroxylase 0.0369904
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0367442
WSB1 WD repeat and SOCS box containing 1 0.036445
MACF1 microtubule-actin crosslinking factor 1 0.0363833
GPBP1 GC-rich promoter binding protein 1 0.0363352
ANTXR2 anthrax toxin receptor 2 0.0363141
ZNF638 zinc finger protein 638 0.0363122
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0362918
PICALM phosphatidylinositol binding clathrin assembly protein 0.0362003
MT2A metallothionein 2A 0.0361078
MKI67 marker of proliferation Ki-67 0.0358223
DOCK1 dedicator of cytokinesis 1 0.0356765
NRXN3 neurexin 3 0.0356143
RAB8B RAB8B, member RAS oncogene family 0.0346812
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0346507
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0345736
QKI QKI, KH domain containing, RNA binding 0.034543
USP37 ubiquitin specific peptidase 37 0.0344805
ELL2 elongation factor, RNA polymerase II, 2 0.0344178
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0343561
TPM1 tropomyosin 1 (alpha) 0.0339755
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0339695
CBX3 chromobox homolog 3 0.0339598
COL8A1 collagen, type VIII, alpha 1 0.0335735
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0332764
FNDC3B fibronectin type III domain containing 3B 0.0331886
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0331202
XPO1 exportin 1 0.032393
TENT2 terminal nucleotidyltransferase 2 0.0322404
DSCAM Down syndrome cell adhesion molecule 0.0317802
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0314825
ANXA2 annexin A2 0.0314697
SYNPO synaptopodin 0.0314325
KDM6A lysine (K)-specific demethylase 6A 0.0310719
PSD3 pleckstrin and Sec7 domain containing 3 0.0310481
RRM2 ribonucleotide reductase M2 0.0303505
PNISR PNN-interacting serine/arginine-rich protein 0.0299696
NCOR1 nuclear receptor corepressor 1 0.0295429
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0292916
RPL30 ribosomal protein L30 0.0292728
IGFBP7 insulin-like growth factor binding protein 7 0.0291471
SNX25 sorting nexin 25 0.0291018
ARGLU1 arginine and glutamate rich 1 0.0290114
AFF3 AF4/FMR2 family, member 3 0.0289802
KYNU kynureninase 0.0283895
TNRC6A trinucleotide repeat containing 6A 0.02837
SBF2 SET binding factor 2 0.0283539
ZNF148 zinc finger protein 148 0.0282774
CPAP centrosome assembly and centriole elongation protein 0.0282702
INSIG2 insulin induced gene 2 0.0280802
LAMB1 laminin, beta 1 0.0279059

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.161522
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105113
HLA-B major histocompatibility complex, class I, B -0.0982354
TGFBI transforming growth factor, beta-induced, 68kDa -0.0968315
FTL ferritin, light polypeptide -0.0899071
SDC4 syndecan 4 -0.0819092
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0741129
TMSB10 thymosin beta 10 -0.0679042
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0658563
UBE2H ubiquitin-conjugating enzyme E2H -0.0615502
COL1A2 collagen, type I, alpha 2 -0.0614744
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0584632
SOD2 superoxide dismutase 2, mitochondrial -0.0578324
LOX lysyl oxidase -0.0570222
ATP13A3 ATPase type 13A3 -0.056984
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0555493
KMT2E lysine (K)-specific methyltransferase 2E -0.0543175
CANX calnexin -0.0526851
VCL vinculin -0.0515246
IL6 interleukin 6 -0.0508558
RPL34 ribosomal protein L34 -0.0478749
TENT5A terminal nucleotidyltransferase 5A -0.0467479
RPS12 ribosomal protein S12 -0.0461675
NDFIP1 Nedd4 family interacting protein 1 -0.0447418
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0437324
MARCHF6 membrane associated ring-CH-type finger 6 -0.0424293
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0418878
IFRD1 interferon-related developmental regulator 1 -0.0411593
FTH1 ferritin, heavy polypeptide 1 -0.0404639
FBXO11 F-box protein 11 -0.0402122
NIPBL Nipped-B homolog (Drosophila) -0.0397231
NF1 neurofibromin 1 -0.0386684
RAB7A RAB7A, member RAS oncogene family -0.0383944
PDIA5 protein disulfide isomerase family A, member 5 -0.0368708
EPAS1 endothelial PAS domain protein 1 -0.0368428
GCC2 GRIP and coiled-coil domain containing 2 -0.0355205
RYBP RING1 and YY1 binding protein -0.0352943
BLTP1 bridge-like lipid transfer protein family member 1 -0.0350376
MAPK8 mitogen-activated protein kinase 8 -0.0348344
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0347531
LCOR ligand dependent nuclear receptor corepressor -0.034598
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0344811
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0344742
AKAP9 A kinase (PRKA) anchor protein 9 -0.0344124
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.034396
EIF4H eukaryotic translation initiation factor 4H -0.0343405
CEP350 centrosomal protein 350kDa -0.0342601
AUTS2 autism susceptibility candidate 2 -0.034253
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0342346
HM13 histocompatibility (minor) 13 -0.0342084
ZFC3H1 zinc finger, C3H1-type containing -0.0340476
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0340189
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0338287
SRSF11 serine/arginine-rich splicing factor 11 -0.0337202
HLA-C major histocompatibility complex, class I, C -0.0331062
NOP58 NOP58 ribonucleoprotein -0.0331033
FRMD4A FERM domain containing 4A -0.0327621
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0324744
NOTCH2 notch 2 -0.0322921
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.031693
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0315807
OSMR oncostatin M receptor -0.0313386
PRELID2 PRELI domain containing 2 -0.0309986
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0306563
POTEF POTE ankyrin domain family, member F -0.0305803
HLA-A major histocompatibility complex, class I, A -0.0304896
FOXP1 forkhead box P1 -0.0303324
CUL3 cullin 3 -0.0302772
KLC1 kinesin light chain 1 -0.03014
MBNL1 muscleblind-like splicing regulator 1 -0.0297873
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0297695
TPM4 tropomyosin 4 -0.0294595
CPNE8 copine VIII -0.0293056
EGR1 early growth response 1 -0.0290541
SRRM2 serine/arginine repetitive matrix 2 -0.0289935
TAS2R14 taste receptor, type 2, member 14 -0.0285479
PRPF3 pre-mRNA processing factor 3 -0.0284183
SSBP2 single-stranded DNA binding protein 2 -0.0281846
PALLD palladin, cytoskeletal associated protein -0.0281092
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0280664
GLS2 glutaminase 2 (liver, mitochondrial) -0.0279563
UBAP1 ubiquitin associated protein 1 -0.027779
TPST1 tyrosylprotein sulfotransferase 1 -0.0277393
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0276403
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0275835
LDHA lactate dehydrogenase A -0.0275457
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0274896
VASP vasodilator-stimulated phosphoprotein -0.0273138
MYO1E myosin IE -0.0271711
GNAS GNAS complex locus -0.0271414
CALR calreticulin -0.027033
SEC23IP SEC23 interacting protein -0.0268891
CTNNBL1 catenin, beta like 1 -0.0268707
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0268414
RPL35A ribosomal protein L35a -0.0267388
CALU calumenin -0.0266098
RPL7A ribosomal protein L7a -0.0266082
RNF216 ring finger protein 216 -0.0263743
TPT1 tumor protein, translationally-controlled 1 -0.0263563
KTN1 kinectin 1 (kinesin receptor) -0.0262533