Ornidazole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ornidazole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ornidazole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.218645
NRG1 neuregulin 1 0.147985
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.102839
NDRG1 N-myc downstream regulated 1 0.0989278
TRIO trio Rho guanine nucleotide exchange factor 0.0967875
VEGFA vascular endothelial growth factor A 0.0946555
CD109 CD109 molecule 0.0935058
FAM13A family with sequence similarity 13, member A 0.0885201
RNF145 ring finger protein 145 0.0744165
TMEM165 transmembrane protein 165 0.073248
STC2 stanniocalcin 2 0.0690212
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0686294
HILPDA hypoxia inducible lipid droplet-associated 0.0603984
MRPS6 mitochondrial ribosomal protein S6 0.0602392
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0588956
HIPK2 homeodomain interacting protein kinase 2 0.0553731
ZFP36L1 ZFP36 ring finger protein-like 1 0.0545997
COPA coatomer protein complex, subunit alpha 0.0543919
ZCCHC7 zinc finger, CCHC domain containing 7 0.0536527
RAI14 retinoic acid induced 14 0.0507459
ZNF292 zinc finger protein 292 0.048801
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0482025
WAC WW domain containing adaptor with coiled-coil 0.0470257
FNDC3B fibronectin type III domain containing 3B 0.0442997
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0441203
CADM1 cell adhesion molecule 1 0.0435143
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0419222
ERRFI1 ERBB receptor feedback inhibitor 1 0.0402626
GRB10 growth factor receptor-bound protein 10 0.0401477
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0400362
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0398463
EYA1 EYA transcriptional coactivator and phosphatase 1 0.038718
TFG TRK-fused gene 0.0385066
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0382587
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.037957
RUNX2 runt-related transcription factor 2 0.0379543
TENT2 terminal nucleotidyltransferase 2 0.037303
RAB1A RAB1A, member RAS oncogene family 0.0359684
ESYT2 extended synaptotagmin-like protein 2 0.0355669
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0346058
PLIN2 perilipin 2 0.0345489
SETD5 SET domain containing 5 0.0345239
MACF1 microtubule-actin crosslinking factor 1 0.0334978
KDM4C lysine (K)-specific demethylase 4C 0.0331662
ENO2 enolase 2 (gamma, neuronal) 0.0328397
RICTOR RPTOR independent companion of MTOR, complex 2 0.0327591
SEC23A Sec23 homolog A (S. cerevisiae) 0.031665
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315467
HELZ helicase with zinc finger 0.0314216
NUP58 nucleoporin 58 0.0307592
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0307206
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0306409
SOS1 son of sevenless homolog 1 (Drosophila) 0.0305572
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0303536
RAB6A RAB6A, member RAS oncogene family 0.0302165
SRP54 signal recognition particle 54kDa 0.030086
CTBP2 C-terminal binding protein 2 0.0299653
INSIG2 insulin induced gene 2 0.0294543
DENND4C DENN/MADD domain containing 4C 0.0294447
KDM6A lysine (K)-specific demethylase 6A 0.0286104
TTC3 tetratricopeptide repeat domain 3 0.0285665
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0284071
PRELID2 PRELI domain containing 2 0.0282881
LIMCH1 LIM and calponin homology domains 1 0.0276153
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0274954
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0274407
DDIT4 DNA-damage-inducible transcript 4 0.0271888
TPD52 tumor protein D52 0.0268076
FNIP1 folliculin interacting protein 1 0.0267948
EPS8 epidermal growth factor receptor pathway substrate 8 0.026757
FAM193B family with sequence similarity 193, member B 0.0265843
PCBP3 poly(rC) binding protein 3 0.0265005
QKI QKI, KH domain containing, RNA binding 0.0264566
GPC6 glypican 6 0.0260368
XPO1 exportin 1 0.0257894
FLNB filamin B, beta 0.0256807
GOLGA4 golgin A4 0.0256545
UBA6 ubiquitin-like modifier activating enzyme 6 0.0254431
UGCG UDP-glucose ceramide glucosyltransferase 0.0253992
GMCL1 germ cell-less, spermatogenesis associated 1 0.0253342
FAT1 FAT atypical cadherin 1 0.0250675
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0248824
SNX13 sorting nexin 13 0.0243606
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0242035
PICALM phosphatidylinositol binding clathrin assembly protein 0.0238971
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0236713
SUCO SUN domain containing ossification factor 0.0235767
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0235715
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0234753
HDGF hepatoma-derived growth factor 0.023468
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0232975
SFMBT2 Scm-like with four mbt domains 2 0.0230652
TRAM1 translocation associated membrane protein 1 0.0228146
RPL3 ribosomal protein L3 0.022579
BIRC6 baculoviral IAP repeat containing 6 0.0225778
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0224782
IRAK3 interleukin-1 receptor-associated kinase 3 0.0220657
SFXN1 sideroflexin 1 0.022005
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0219558
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0219057

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188087
FN1 fibronectin 1 -0.176225
FTH1 ferritin, heavy polypeptide 1 -0.164718
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.154731
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.113468
EXT1 exostosin glycosyltransferase 1 -0.109168
ASPH aspartate beta-hydroxylase -0.101477
MT2A metallothionein 2A -0.0819345
SQSTM1 sequestosome 1 -0.0804243
CANX calnexin -0.0785809
OSMR oncostatin M receptor -0.0739245
HLA-B major histocompatibility complex, class I, B -0.0728151
GLIS3 GLIS family zinc finger 3 -0.0712506
VIM vimentin -0.0653517
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0651148
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0638229
IFI16 interferon, gamma-inducible protein 16 -0.0628531
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0624939
VCL vinculin -0.062248
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0620616
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0613537
UBC ubiquitin C -0.0597708
MAP1B microtubule-associated protein 1B -0.0594214
LOC112694756 uncharaterized LOC112694756 -0.0558461
NRP1 neuropilin 1 -0.0558324
TMSB10 thymosin beta 10 -0.0558066
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0545193
TOP1 topoisomerase (DNA) I -0.0538223
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0534602
FOXP1 forkhead box P1 -0.0526843
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0524439
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0521979
TMEM156 transmembrane protein 156 -0.0491743
S100A6 S100 calcium binding protein A6 -0.0489805
SVIL supervillin -0.0484402
AHNAK AHNAK nucleoprotein -0.0475504
RPL12 ribosomal protein L12 -0.0465218
CD44 CD44 molecule (Indian blood group) -0.0464069
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.046009
ARF1 ADP-ribosylation factor 1 -0.0445912
RPS27A ribosomal protein S27a -0.043931
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0435596
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0434347
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0431837
RPL23 ribosomal protein L23 -0.042932
TXNRD1 thioredoxin reductase 1 -0.0410294
NCOA7 nuclear receptor coactivator 7 -0.040843
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0395919
TPT1 tumor protein, translationally-controlled 1 -0.0386616
ACTN4 actinin, alpha 4 -0.0385265
BICD1 bicaudal D homolog 1 (Drosophila) -0.0382881
RNF213 ring finger protein 213 -0.0368821
KLHL5 kelch-like family member 5 -0.0359443
RPL35A ribosomal protein L35a -0.0358703
FTL ferritin, light polypeptide -0.0357542
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0353468
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0352964
RRBP1 ribosome binding protein 1 -0.0351222
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0350811
RPS24 ribosomal protein S24 -0.0347067
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0342077
RIGI RNA sensor RIG-I -0.0341702
PCBP2 poly(rC) binding protein 2 -0.0335568
PDE4D phosphodiesterase 4D, cAMP-specific -0.0335266
MX1 MX dynamin-like GTPase 1 -0.0334773
PRRC2C proline-rich coiled-coil 2C -0.0326428
ALCAM activated leukocyte cell adhesion molecule -0.032504
CALU calumenin -0.0323593
NTN4 netrin 4 -0.032129
BZW1 basic leucine zipper and W2 domains 1 -0.0320839
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0315142
RAB7A RAB7A, member RAS oncogene family -0.0313432
ENO1 enolase 1, (alpha) -0.0312973
THBS1 thrombospondin 1 -0.031145
RPLP1 ribosomal protein, large, P1 -0.0311433
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0307055
CAPN2 calpain 2, (m/II) large subunit -0.0306515
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0303217
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0302782
RPL26 ribosomal protein L26 -0.0301873
RAB31 RAB31, member RAS oncogene family -0.0299766
IER3 immediate early response 3 -0.0299615
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0297407
YBX3 Y box binding protein 3 -0.0296262
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0293977
IFI27 interferon, alpha-inducible protein 27 -0.0293784
ANKRD28 ankyrin repeat domain 28 -0.0292188
GNAS GNAS complex locus -0.0290219
SDC4 syndecan 4 -0.0289519
EZR ezrin -0.0288165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0285657
SYT1 synaptotagmin I -0.0282354
RANBP17 RAN binding protein 17 -0.0281346
DST dystonin -0.0280844
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0279668
EEF2 eukaryotic translation elongation factor 2 -0.0272893
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0272421
EIF1 eukaryotic translation initiation factor 1 -0.0271982
ETV1 ets variant 1 -0.0270755
RPS20 ribosomal protein S20 -0.0267976