| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0752764 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0618066 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0416058 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0367941 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0367585 |
| SQSTM1 | sequestosome 1 | 0.0348595 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0305728 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0303868 |
| OGA | O-GlcNAcase | 0.0299039 |
| ADM | adrenomedullin | 0.0286408 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0282106 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0272859 |
| GOLGA4 | golgin A4 | 0.0269257 |
| FBN1 | fibrillin 1 | 0.0258406 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0236824 |
| SFTPA2 | surfactant protein A2 | 0.0232415 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.02264 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0218223 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0211338 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0209991 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0199633 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0195503 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0192837 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0191022 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0189595 |
| XPO1 | exportin 1 | 0.018947 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0187765 |
| APP | amyloid beta (A4) precursor protein | 0.0186434 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0185825 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0181776 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0180851 |
| HELZ | helicase with zinc finger | 0.0176221 |
| ARRDC3 | arrestin domain containing 3 | 0.0169988 |
| CTSB | cathepsin B | 0.016939 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0167892 |
| RND3 | Rho family GTPase 3 | 0.0164264 |
| CD109 | CD109 molecule | 0.016394 |
| CANX | calnexin | 0.0163903 |
| PTMA | prothymosin, alpha | 0.0162584 |
| FMNL2 | formin-like 2 | 0.016241 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0161851 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0161743 |
| OPTN | optineurin | 0.0160674 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0160187 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0159039 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0151598 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0148857 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0145803 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.01456 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0145324 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.014418 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0141402 |
| TMSB4X | thymosin beta 4, X-linked | 0.0141266 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0140962 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0139754 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0139166 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0138366 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.013711 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0134703 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0133778 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0133298 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0132042 |
| ATP13A3 | ATPase type 13A3 | 0.0132021 |
| INSIG2 | insulin induced gene 2 | 0.0131228 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0127156 |
| DTNA | dystrobrevin, alpha | 0.0127004 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.012527 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0124578 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0124181 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0123975 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0123759 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0122906 |
| DENND5A | DENN/MADD domain containing 5A | 0.0122193 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0117917 |
| CCSAP | centriole, cilia and spindle-associated protein | 0.0115106 |
| NAV2 | neuron navigator 2 | 0.0114945 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0114774 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0112771 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0111735 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0110884 |
| RPS2 | ribosomal protein S2 | 0.0108375 |
| AUTS2 | autism susceptibility candidate 2 | 0.0107457 |
| CTBP2 | C-terminal binding protein 2 | 0.0106371 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0105477 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0104951 |
| UBC | ubiquitin C | 0.0104638 |
| FAM107B | family with sequence similarity 107, member B | 0.0102939 |
| ABI1 | abl-interactor 1 | 0.0102628 |
| RYBP | RING1 and YY1 binding protein | 0.0102125 |
| HMGB2 | high mobility group box 2 | 0.0101249 |
| WTAP | Wilms tumor 1 associated protein | 0.00994052 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.00984165 |
| ANKRD36 | ankyrin repeat domain 36 | 0.00983862 |
| PCGF5 | polycomb group ring finger 5 | 0.0098144 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.00976906 |
| NUP58 | nucleoporin 58 | 0.00966709 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00957283 |
| CLU | clusterin | 0.00948341 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00947437 |
| RPS3 | ribosomal protein S3 | 0.00937227 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.160764 |
| VIM | vimentin | -0.134307 |
| TMSB10 | thymosin beta 10 | -0.106634 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.103895 |
| NAV1 | neuron navigator 1 | -0.0939402 |
| PLAT | plasminogen activator, tissue | -0.0866425 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0830269 |
| PODXL | podocalyxin-like | -0.0747717 |
| MAP1B | microtubule-associated protein 1B | -0.0679711 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0640834 |
| S100A10 | S100 calcium binding protein A10 | -0.0639793 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0584891 |
| MT2A | metallothionein 2A | -0.0552649 |
| POTEF | POTE ankyrin domain family, member F | -0.0530429 |
| FN1 | fibronectin 1 | -0.0498756 |
| CDH13 | cadherin 13 | -0.0467513 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0465187 |
| SUCNR1 | succinate receptor 1 | -0.0456206 |
| HLA-B | major histocompatibility complex, class I, B | -0.0443982 |
| LOX | lysyl oxidase | -0.0396661 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0396519 |
| MX2 | MX dynamin-like GTPase 2 | -0.0388346 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0383153 |
| PRSS23 | protease, serine, 23 | -0.0375656 |
| TAGLN2 | transgelin 2 | -0.0372888 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0358392 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.035243 |
| CD44 | CD44 molecule (Indian blood group) | -0.0348392 |
| COL5A1 | collagen, type V, alpha 1 | -0.033896 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0333044 |
| CD99 | CD99 molecule | -0.0326498 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0312514 |
| EFNA5 | ephrin-A5 | -0.0308726 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0300384 |
| LMNA | lamin A/C | -0.0296339 |
| RIGI | RNA sensor RIG-I | -0.0294271 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0292027 |
| NDRG1 | N-myc downstream regulated 1 | -0.0280912 |
| GLIS3 | GLIS family zinc finger 3 | -0.0274592 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0261481 |
| CUX1 | cut-like homeobox 1 | -0.0258617 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0258448 |
| S100A6 | S100 calcium binding protein A6 | -0.0256857 |
| HLA-C | major histocompatibility complex, class I, C | -0.0250632 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0250357 |
| ASPH | aspartate beta-hydroxylase | -0.0249233 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0247728 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0247065 |
| LOC112694756 | uncharaterized LOC112694756 | -0.024676 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.024541 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0243082 |
| ACTG1 | actin gamma 1 | -0.0236987 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0235666 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0232402 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.023167 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0218023 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0214399 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0211414 |
| RNF213 | ring finger protein 213 | -0.0207862 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0206614 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0205698 |
| LRRC17 | leucine rich repeat containing 17 | -0.0205661 |
| PKM | pyruvate kinase, muscle | -0.0204694 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.020384 |
| MT1X | metallothionein 1X | -0.0197574 |
| PFN1 | profilin 1 | -0.0195565 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.01921 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0189257 |
| RTN4 | reticulon 4 | -0.0189123 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0189099 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.018905 |
| BPTF | bromodomain PHD finger transcription factor | -0.018811 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0187317 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0186756 |
| S100A4 | S100 calcium binding protein A4 | -0.0186467 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0185988 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0185457 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0183991 |
| TPM4 | tropomyosin 4 | -0.0183982 |
| BSG | basigin (Ok blood group) | -0.0183095 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0181816 |
| SP100 | SP100 nuclear antigen | -0.0181731 |
| CDK6 | cyclin-dependent kinase 6 | -0.0180649 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0180466 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0180147 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0179854 |
| PLXNA2 | plexin A2 | -0.0179851 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.017909 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0177746 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0176091 |
| GNAS | GNAS complex locus | -0.0173782 |
| EGFR | epidermal growth factor receptor | -0.0172728 |
| DCLK2 | doublecortin-like kinase 2 | -0.0171708 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0169908 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0169483 |
| TPM1 | tropomyosin 1 (alpha) | -0.0166012 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0165931 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0164605 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0164579 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0164127 |
