| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.120685 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.093095 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0805842 |
| PCBP2 | poly(rC) binding protein 2 | 0.0767485 |
| MKI67 | marker of proliferation Ki-67 | 0.0760265 |
| ANXA1 | annexin A1 | 0.0707203 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0683205 |
| AREG | amphiregulin | 0.0543417 |
| RPS3 | ribosomal protein S3 | 0.0508082 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0483553 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0456551 |
| KIF5B | kinesin family member 5B | 0.0453123 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0449446 |
| PCM1 | pericentriolar material 1 | 0.0448343 |
| TPM3 | tropomyosin 3 | 0.0435823 |
| HDGF | hepatoma-derived growth factor | 0.0409851 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0389641 |
| PRKCI | protein kinase C, iota | 0.0374235 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0363281 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0353402 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0353137 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0350317 |
| SFTPA2 | surfactant protein A2 | 0.0348264 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.033705 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0327031 |
| PCDH9 | protocadherin 9 | 0.0325862 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0324434 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0318135 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0316754 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0304095 |
| HLA-A | major histocompatibility complex, class I, A | 0.0303319 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0301904 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0300717 |
| PTMS | parathymosin | 0.0299813 |
| TMEM41B | transmembrane protein 41B | 0.0296495 |
| SET | SET nuclear proto-oncogene | 0.0296029 |
| CPOX | coproporphyrinogen oxidase | 0.0291997 |
| RRM2 | ribonucleotide reductase M2 | 0.0291472 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0289712 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0285999 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0283106 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0279828 |
| CALR | calreticulin | 0.0277375 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0276469 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0276107 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0274205 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0263819 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0261865 |
| EHBP1 | EH domain binding protein 1 | 0.0256791 |
| FAM13B | family with sequence similarity 13, member B | 0.0254253 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0250548 |
| RPL3 | ribosomal protein L3 | 0.0250096 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0249637 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0247306 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0245428 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0241848 |
| SSRP1 | structure specific recognition protein 1 | 0.0241165 |
| PNN | pinin, desmosome associated protein | 0.0237581 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0237026 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0235824 |
| CEP70 | centrosomal protein 70kDa | 0.0234751 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0234164 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0233036 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0232402 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0232168 |
| MCL1 | myeloid cell leukemia 1 | 0.0229075 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.0225452 |
| JMJD1C | jumonji domain containing 1C | 0.0223961 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.0223567 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0222022 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0221681 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0220214 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0217126 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.021467 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0214492 |
| CEP192 | centrosomal protein 192kDa | 0.0211276 |
| YTHDC1 | YTH domain containing 1 | 0.0210652 |
| CCN2 | cellular communication network factor 2 | 0.0209419 |
| VIM | vimentin | 0.0208503 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0205616 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.02035 |
| UBC | ubiquitin C | 0.0202123 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0200057 |
| UNC13A | unc-13 homolog A (C. elegans) | 0.0199932 |
| EZR | ezrin | 0.0198525 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0198431 |
| CLDND1 | claudin domain containing 1 | 0.0198024 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0197732 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.019599 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0195507 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0195204 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0194033 |
| TPX2 | TPX2, microtubule-associated | 0.0189923 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0187538 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0187087 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0185512 |
| FOXM1 | forkhead box M1 | 0.0185333 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0183148 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.01825 |
| APP | amyloid beta (A4) precursor protein | 0.0182452 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.347475 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.215296 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.166701 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.104941 |
| MGAT4C | MGAT4 family, member C | -0.103989 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.103533 |
| TMSB10 | thymosin beta 10 | -0.0982522 |
| SLC38A2 | solute carrier family 38, member 2 | -0.089767 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0855911 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0674958 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0661033 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.064084 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0635021 |
| ACTG1 | actin gamma 1 | -0.0610045 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0570179 |
| RPS6 | ribosomal protein S6 | -0.0567879 |
| RPLP0 | ribosomal protein, large, P0 | -0.0562848 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0562129 |
| TENM3 | teneurin transmembrane protein 3 | -0.0556315 |
| HMGA1 | high mobility group AT-hook 1 | -0.0553639 |
| PCDH7 | protocadherin 7 | -0.0551671 |
| NEK7 | NIMA-related kinase 7 | -0.0550797 |
| RPL23 | ribosomal protein L23 | -0.0546689 |
| RPS24 | ribosomal protein S24 | -0.0545825 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0544105 |
| BCHE | butyrylcholinesterase | -0.0544045 |
| RPLP1 | ribosomal protein, large, P1 | -0.0536232 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0533835 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0532222 |
| RPL19 | ribosomal protein L19 | -0.0529121 |
| EDARADD | EDAR-associated death domain | -0.0522484 |
| RPS21 | ribosomal protein S21 | -0.051623 |
| LMO7 | LIM domain 7 | -0.0500943 |
| TMEM123 | transmembrane protein 123 | -0.0492848 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0473234 |
| MMP12 | matrix metallopeptidase 12 | -0.0472174 |
| RPL34 | ribosomal protein L34 | -0.0467083 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0458577 |
| ZNF217 | zinc finger protein 217 | -0.0452513 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.044869 |
| PRR16 | proline rich 16 | -0.0441586 |
| RPLP2 | ribosomal protein, large, P2 | -0.0438915 |
| NLGN1 | neuroligin 1 | -0.0432576 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0410978 |
| TXNRD1 | thioredoxin reductase 1 | -0.0393111 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0384176 |
| RPS5 | ribosomal protein S5 | -0.0381491 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.03693 |
| RPL32 | ribosomal protein L32 | -0.0367413 |
| RPS20 | ribosomal protein S20 | -0.0356078 |
| RPL5 | ribosomal protein L5 | -0.0352063 |
| PDGFC | platelet derived growth factor C | -0.0348222 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0348167 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0344049 |
| RPL12 | ribosomal protein L12 | -0.0343386 |
| RPL9 | ribosomal protein L9 | -0.0335634 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0333465 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.033135 |
| SQSTM1 | sequestosome 1 | -0.0326167 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0325737 |
| RPL11 | ribosomal protein L11 | -0.0324494 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0323093 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0322368 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0320699 |
| FUS | FUS RNA binding protein | -0.0319241 |
| IL6ST | interleukin 6 signal transducer | -0.0316653 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0315426 |
| ECT2 | epithelial cell transforming 2 | -0.0315216 |
| HMGA2 | high mobility group AT-hook 2 | -0.031332 |
| EXOC6B | exocyst complex component 6B | -0.0313135 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0308989 |
| RPL38 | ribosomal protein L38 | -0.0308872 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0307743 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0305961 |
| RPS8 | ribosomal protein S8 | -0.0305636 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0303896 |
| NHSL1 | NHS-like 1 | -0.0298974 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0298542 |
| RPS29 | ribosomal protein S29 | -0.0298334 |
| MPG | N-methylpurine-DNA glycosylase | -0.0295286 |
| ATP11A | ATPase, class VI, type 11A | -0.0293428 |
| RPL35A | ribosomal protein L35a | -0.0289801 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0283884 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0283833 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0281531 |
| GNAS | GNAS complex locus | -0.0279132 |
| RPS16 | ribosomal protein S16 | -0.0278463 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0270776 |
| RPL6 | ribosomal protein L6 | -0.026958 |
| AHNAK | AHNAK nucleoprotein | -0.0268392 |
| RPS15 | ribosomal protein S15 | -0.0267097 |
| SYT1 | synaptotagmin I | -0.0265376 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0265036 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0264306 |
| RPS10 | ribosomal protein S10 | -0.0263459 |
| RPS23 | ribosomal protein S23 | -0.0262806 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0262433 |
| USP34 | ubiquitin specific peptidase 34 | -0.0258494 |
| TUBB | tubulin, beta class I | -0.0256839 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0253921 |
