| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.139115 |
| ASPH | aspartate beta-hydroxylase | 0.10796 |
| VIM | vimentin | 0.061816 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0565654 |
| ARRDC3 | arrestin domain containing 3 | 0.0549931 |
| B2M | beta-2-microglobulin | 0.0522443 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0500555 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0494703 |
| NRP2 | neuropilin 2 | 0.0489139 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.047698 |
| APOL1 | apolipoprotein L, 1 | 0.0474545 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0447294 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0415807 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0398956 |
| TXNRD1 | thioredoxin reductase 1 | 0.039459 |
| PLK2 | polo-like kinase 2 | 0.0394218 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0383353 |
| CALR | calreticulin | 0.0378639 |
| APP | amyloid beta (A4) precursor protein | 0.0367773 |
| CALU | calumenin | 0.0360527 |
| CA12 | carbonic anhydrase XII | 0.0357944 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0350898 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0350441 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0347841 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0344822 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0335829 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0321239 |
| MKI67 | marker of proliferation Ki-67 | 0.031716 |
| CANX | calnexin | 0.031497 |
| LOXL2 | lysyl oxidase-like 2 | 0.0313293 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0312774 |
| CD44 | CD44 molecule (Indian blood group) | 0.0309943 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0302142 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0299473 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0293241 |
| PTMA | prothymosin, alpha | 0.0292779 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0282056 |
| MT2A | metallothionein 2A | 0.0280039 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0276621 |
| HLA-B | major histocompatibility complex, class I, B | 0.0273293 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0267846 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0267227 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0266343 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0264899 |
| ANXA2 | annexin A2 | 0.0263866 |
| CAPRIN1 | cell cycle associated protein 1 | 0.0263522 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0259543 |
| SFTPA2 | surfactant protein A2 | 0.0258099 |
| IRS2 | insulin receptor substrate 2 | 0.0256444 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.025424 |
| CENPF | centromere protein F, 350/400kDa | 0.0252157 |
| VCAN | versican | 0.0251821 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.025153 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0249341 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0243927 |
| ADAR | adenosine deaminase, RNA-specific | 0.0243011 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0242708 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0240177 |
| TGFB2 | transforming growth factor, beta 2 | 0.0238636 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0238633 |
| XPOT | exportin, tRNA | 0.0233955 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0230488 |
| LDHA | lactate dehydrogenase A | 0.0227146 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0220885 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0218963 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.021846 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0216218 |
| CP | ceruloplasmin (ferroxidase) | 0.0216064 |
| HLA-C | major histocompatibility complex, class I, C | 0.0212982 |
| ANLN | anillin, actin binding protein | 0.0210396 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0210017 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.020989 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0208682 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0208466 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0206079 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0203557 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.020173 |
| SET | SET nuclear proto-oncogene | 0.019999 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0198671 |
| NRP1 | neuropilin 1 | 0.0198405 |
| CDCP1 | CUB domain containing protein 1 | 0.0196144 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0195055 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0193737 |
| SP3 | Sp3 transcription factor | 0.0193002 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0192666 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0192121 |
| TPM3 | tropomyosin 3 | 0.0191914 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0190378 |
| ADM | adrenomedullin | 0.0187979 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.018636 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0185654 |
| ZBTB41 | zinc finger and BTB domain containing 41 | 0.0185408 |
| JAK1 | Janus kinase 1 | 0.0184393 |
| RPS27A | ribosomal protein S27a | 0.018373 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0181422 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0180021 |
| PLIN2 | perilipin 2 | 0.0179969 |
| TNPO1 | transportin 1 | 0.0177695 |
| H3-3B | H3.3 histone B | 0.0171129 |
| RPL7A | ribosomal protein L7a | 0.0170164 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.100227 |
| FRMD4A | FERM domain containing 4A | -0.092098 |
| NDRG1 | N-myc downstream regulated 1 | -0.0694199 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0665299 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0579742 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0579165 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0449109 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0434797 |
| CADM1 | cell adhesion molecule 1 | -0.0408666 |
| GPC6 | glypican 6 | -0.0388607 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0370815 |
| SPAG9 | sperm associated antigen 9 | -0.0362287 |
| FMNL2 | formin-like 2 | -0.0359008 |
| INTS6 | integrator complex subunit 6 | -0.0353512 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.033084 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0320737 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0312118 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0308044 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0290439 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0289553 |
| DGKI | diacylglycerol kinase, iota | -0.0285415 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0284544 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0282841 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0280415 |
| RPS6 | ribosomal protein S6 | -0.0277284 |
| UBAP2 | ubiquitin associated protein 2 | -0.0273517 |
| CTBP2 | C-terminal binding protein 2 | -0.0272274 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.026784 |
| RIGI | RNA sensor RIG-I | -0.0265964 |
| COPA | coatomer protein complex, subunit alpha | -0.0257547 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0251486 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0250083 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0248671 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0246982 |
| DENND4A | DENN/MADD domain containing 4A | -0.0244255 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0242387 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0238004 |
| FBXO11 | F-box protein 11 | -0.0237646 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0237587 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0236579 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0234419 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0234373 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0232685 |
| PTK2 | protein tyrosine kinase 2 | -0.0231214 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0228822 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0228167 |
| PFN1 | profilin 1 | -0.0227867 |
| LAMA5 | laminin, alpha 5 | -0.0227446 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0225857 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0225698 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0223286 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0222879 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0221388 |
| ATF3 | activating transcription factor 3 | -0.0220928 |
| SORCS2 | sortilin-related VPS10 domain containing receptor 2 | -0.0220916 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0217155 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0216926 |
| HMGA1 | high mobility group AT-hook 1 | -0.0215485 |
| MSR1 | macrophage scavenger receptor 1 | -0.0214778 |
| RUNX1 | runt-related transcription factor 1 | -0.0212604 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0211747 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0209596 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0209153 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0207201 |
| NOP58 | NOP58 ribonucleoprotein | -0.0205204 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0204845 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0204626 |
| CTSD | cathepsin D | -0.0204435 |
| EFNA5 | ephrin-A5 | -0.0203233 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0199417 |
| SEC24D | SEC24 family member D | -0.0194895 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0194653 |
| KYNU | kynureninase | -0.0194581 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0194544 |
| SP100 | SP100 nuclear antigen | -0.0192616 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0192308 |
| ZNF207 | zinc finger protein 207 | -0.0192056 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.0191621 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0191298 |
| MCL1 | myeloid cell leukemia 1 | -0.0190102 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0189139 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0188709 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0188022 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0187931 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0187632 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0187214 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.0184819 |
| POTEF | POTE ankyrin domain family, member F | -0.018459 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0184502 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0183114 |
| ZNF644 | zinc finger protein 644 | -0.0182973 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0182002 |
| HBP1 | HMG-box transcription factor 1 | -0.0179818 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.017862 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0177095 |
| RNF213 | ring finger protein 213 | -0.0176134 |
| EGR1 | early growth response 1 | -0.0174344 |
| TLE4 | transducin-like enhancer of split 4 | -0.0174077 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.0173741 |
| NUP98 | nucleoporin 98kDa | -0.0172769 |
