| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Osimertinib (mesylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.200291 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0469416 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0354892 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0341634 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0279531 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0231981 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0230544 |
| SFTPA2 | surfactant protein A2 | 0.0204315 |
| PCBP2 | poly(rC) binding protein 2 | 0.018061 |
| TMSB4X | thymosin beta 4, X-linked | 0.016491 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0163859 |
| ADM | adrenomedullin | 0.0159544 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0155914 |
| NUP58 | nucleoporin 58 | 0.0144945 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0136845 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0128028 |
| PGK1 | phosphoglycerate kinase 1 | 0.0126027 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0124894 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0120614 |
| DHFR | dihydrofolate reductase | 0.0119273 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.01187 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0111587 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0111192 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0106596 |
| C1D | C1D nuclear receptor corepressor | 0.0104998 |
| LAMB3 | laminin, beta 3 | 0.0101173 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00966982 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0090745 |
| OGA | O-GlcNAcase | 0.0090115 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.00875873 |
| RPS7 | ribosomal protein S7 | 0.00853354 |
| ARRDC3 | arrestin domain containing 3 | 0.00843527 |
| ZFP36 | ZFP36 ring finger protein | 0.00839849 |
| KDM1A | lysine (K)-specific demethylase 1A | 0.00830475 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0081646 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00809589 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.00801846 |
| LMAN1 | lectin, mannose-binding, 1 | 0.00797445 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.00789686 |
| TFG | TRK-fused gene | 0.00774076 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00763623 |
| RAB18 | RAB18, member RAS oncogene family | 0.0076236 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.00760675 |
| RACK1 | receptor for activated C kinase 1 | 0.00759261 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.00745903 |
| RNF169 | ring finger protein 169 | 0.00744957 |
| CTSB | cathepsin B | 0.00735023 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.00706612 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.00706002 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00701877 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.00692775 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.00692432 |
| PTMA | prothymosin, alpha | 0.00685654 |
| RARB | retinoic acid receptor, beta | 0.00680734 |
| SRP54 | signal recognition particle 54kDa | 0.00677914 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.00677475 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00675823 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.00666508 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.00666132 |
| DAPK3 | death-associated protein kinase 3 | 0.00665399 |
| FNBP1L | formin binding protein 1-like | 0.00664308 |
| PREPL | prolyl endopeptidase-like | 0.00662616 |
| PLIN2 | perilipin 2 | 0.00658295 |
| SPAG5 | sperm associated antigen 5 | 0.00656077 |
| FTL | ferritin, light polypeptide | 0.00650686 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0064995 |
| RPL35A | ribosomal protein L35a | 0.00647612 |
| FDPS | farnesyl diphosphate synthase | 0.00634857 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00631181 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.00630109 |
| STRN4 | striatin, calmodulin binding protein 4 | 0.00624245 |
| SEC24C | SEC24 family member C | 0.00624233 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.00622114 |
| PTMS | parathymosin | 0.00621011 |
| MUSK | muscle, skeletal, receptor tyrosine kinase | 0.00620698 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.00613977 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.00613363 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00612488 |
| WDR45B | WD repeat domain 45B | 0.00608403 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.0060502 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00598918 |
| BEST1 | bestrophin 1 | 0.00598519 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0059534 |
| GOLGA2 | golgin A2 | 0.00593917 |
| HELZ | helicase with zinc finger | 0.0059373 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.00585112 |
| FDXR | ferredoxin reductase | 0.00585101 |
| JMJD6 | jumonji domain containing 6 | 0.0058411 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.00583233 |
| DNAJC25 | DnaJ (Hsp40) homolog, subfamily C , member 25 | 0.00582944 |
| TPR | translocated promoter region, nuclear basket protein | 0.0057337 |
| CLIC1 | chloride intracellular channel 1 | 0.00567753 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.00567552 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.00567413 |
| CCDC9 | coiled-coil domain containing 9 | 0.00563228 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.005621 |
| PPME1 | protein phosphatase methylesterase 1 | 0.00559624 |
| NGFR | nerve growth factor receptor | 0.00552466 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00551397 |
| RPS3A | ribosomal protein S3A | 0.00550033 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.328958 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.185742 |
| EFNA5 | ephrin-A5 | -0.158237 |
| PDE10A | phosphodiesterase 10A | -0.118371 |
| FNDC3B | fibronectin type III domain containing 3B | -0.107208 |
| ASPH | aspartate beta-hydroxylase | -0.106842 |
| ACTG1 | actin gamma 1 | -0.106626 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.100781 |
| KYNU | kynureninase | -0.0951052 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0861229 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0819848 |
| NDRG1 | N-myc downstream regulated 1 | -0.0803127 |
| SMAD3 | SMAD family member 3 | -0.0779509 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0728063 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0716404 |
| ANXA2 | annexin A2 | -0.0709668 |
| PARD3 | par-3 family cell polarity regulator | -0.0667408 |
| EGFR | epidermal growth factor receptor | -0.0665117 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.064824 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0634824 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0612967 |
| RPS6 | ribosomal protein S6 | -0.0607647 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0602991 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0599464 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0594564 |
| AUTS2 | autism susceptibility candidate 2 | -0.0593607 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0593161 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0561756 |
| VCL | vinculin | -0.0550632 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0542467 |
| CA12 | carbonic anhydrase XII | -0.0534443 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0534049 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0533464 |
| FAM107B | family with sequence similarity 107, member B | -0.0529267 |
| STC1 | stanniocalcin 1 | -0.0518333 |
| TXNRD1 | thioredoxin reductase 1 | -0.0506575 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0502696 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0487074 |
| PTK2 | protein tyrosine kinase 2 | -0.047483 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0453896 |
| EHBP1 | EH domain binding protein 1 | -0.0452995 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0451992 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0450095 |
| MYO1E | myosin IE | -0.0448883 |
| PRKCA | protein kinase C, alpha | -0.0439685 |
| PKM | pyruvate kinase, muscle | -0.0435373 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0431563 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0426092 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0422448 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0418152 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0415338 |
| USP34 | ubiquitin specific peptidase 34 | -0.0413662 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0413117 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0409279 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0391538 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0390784 |
| EXOC6B | exocyst complex component 6B | -0.0387388 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0384631 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0383489 |
| SMYD3 | SET and MYND domain containing 3 | -0.0381764 |
| DST | dystonin | -0.0380885 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0379771 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0379016 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0378902 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0374192 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0372042 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0368421 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0367368 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0356698 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0355701 |
| FLNB | filamin B, beta | -0.0353411 |
| POTEF | POTE ankyrin domain family, member F | -0.034952 |
| RNF213 | ring finger protein 213 | -0.034879 |
| MYO10 | myosin X | -0.034366 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0342369 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0338833 |
| RAI14 | retinoic acid induced 14 | -0.0338316 |
| RAD51B | RAD51 paralog B | -0.0336295 |
| IGF1R | insulin-like growth factor 1 receptor | -0.033513 |
| NF1 | neurofibromin 1 | -0.0333631 |
| GOLGB1 | golgin B1 | -0.033122 |
| NRG1 | neuregulin 1 | -0.0330152 |
| RIGI | RNA sensor RIG-I | -0.0328085 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0325525 |
| JMJD1C | jumonji domain containing 1C | -0.0324798 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0322387 |
| TBC1D5 | TBC1 domain family, member 5 | -0.03141 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0312936 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.031192 |
| CMIP | c-Maf inducing protein | -0.0308389 |
| MCL1 | myeloid cell leukemia 1 | -0.0305447 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0305428 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0305081 |
| FBXO11 | F-box protein 11 | -0.030373 |
| LDHA | lactate dehydrogenase A | -0.0301338 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0295786 |
| TMSB10 | thymosin beta 10 | -0.0295367 |
| RIN2 | Ras and Rab interactor 2 | -0.0291621 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.029073 |
| GLIS3 | GLIS family zinc finger 3 | -0.0289514 |
