| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.310673 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.103574 |
| VEGFA | vascular endothelial growth factor A | 0.100034 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0864685 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0665094 |
| RPS2 | ribosomal protein S2 | 0.060032 |
| ZNF292 | zinc finger protein 292 | 0.0593958 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.057967 |
| SFTPA2 | surfactant protein A2 | 0.0565364 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0544602 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0521593 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0480784 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0453581 |
| TMSB4X | thymosin beta 4, X-linked | 0.0442929 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0435333 |
| RPL3 | ribosomal protein L3 | 0.0432251 |
| PCBP2 | poly(rC) binding protein 2 | 0.0425878 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.042466 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0421746 |
| PDE10A | phosphodiesterase 10A | 0.0417796 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.040003 |
| PRELID2 | PRELI domain containing 2 | 0.0384875 |
| KIF11 | kinesin family member 11 | 0.0378453 |
| DIPK2A | divergent protein kinase domain 2A | 0.0373707 |
| CCNL1 | cyclin L1 | 0.0353506 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0337032 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0333661 |
| RREB1 | ras responsive element binding protein 1 | 0.032799 |
| B2M | beta-2-microglobulin | 0.032765 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0326814 |
| MXI1 | MAX interactor 1, dimerization protein | 0.031849 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0318395 |
| BCOR | BCL6 corepressor | 0.031468 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0313855 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0313694 |
| BRD2 | bromodomain containing 2 | 0.0312026 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0303658 |
| TPM3 | tropomyosin 3 | 0.0286206 |
| TOP1 | topoisomerase (DNA) I | 0.0285198 |
| ZNF608 | zinc finger protein 608 | 0.0276114 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0275277 |
| MATR3 | matrin 3 | 0.0271739 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0269172 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0266317 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0264292 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0258363 |
| CANX | calnexin | 0.0258354 |
| MLEC | malectin | 0.025822 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0256052 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0248645 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0245202 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.024491 |
| SPAG5 | sperm associated antigen 5 | 0.0242187 |
| RCOR1 | REST corepressor 1 | 0.0235715 |
| SECISBP2L | SECIS binding protein 2-like | 0.0234959 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0234861 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0233779 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0231068 |
| SH3PXD2A | SH3 and PX domains 2A | 0.0229481 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0228741 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0227373 |
| YTHDC1 | YTH domain containing 1 | 0.0227104 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0225907 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0224136 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0223445 |
| RPS18 | ribosomal protein S18 | 0.0223312 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0221425 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0219491 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0218669 |
| XPO1 | exportin 1 | 0.021835 |
| CEP192 | centrosomal protein 192kDa | 0.0216606 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0216497 |
| FGF10 | fibroblast growth factor 10 | 0.0215968 |
| RNF150 | ring finger protein 150 | 0.0215921 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0215744 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0214116 |
| INSIG2 | insulin induced gene 2 | 0.0210809 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0209734 |
| SF1 | splicing factor 1 | 0.0209394 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.020786 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.0207514 |
| ITSN2 | intersectin 2 | 0.0207044 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0206921 |
| RBM27 | RNA binding motif protein 27 | 0.0206896 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0206047 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0205992 |
| USP33 | ubiquitin specific peptidase 33 | 0.0205821 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0204387 |
| CALR | calreticulin | 0.0203651 |
| RNF145 | ring finger protein 145 | 0.0203643 |
| CABIN1 | calcineurin binding protein 1 | 0.0203588 |
| RBM17 | RNA binding motif protein 17 | 0.0202 |
| MACO1 | macoilin 1 | 0.0201612 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0200988 |
| UVRAG | UV radiation resistance associated | 0.0200212 |
| IL17RD | interleukin 17 receptor D | 0.0200142 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0198928 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0197385 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0197208 |
| DNAJC8 | DnaJ (Hsp40) homolog, subfamily C, member 8 | 0.0196429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19959 |
| CADM2 | cell adhesion molecule 2 | -0.161581 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0776422 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0723484 |
| TUBB | tubulin, beta class I | -0.0638042 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0612225 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0591107 |
| ACTG1 | actin gamma 1 | -0.0580609 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0572882 |
| PEG10 | paternally expressed 10 | -0.0571571 |
| RPS24 | ribosomal protein S24 | -0.0567125 |
| TMSB10 | thymosin beta 10 | -0.0525846 |
| MGP | matrix Gla protein | -0.0522373 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0517401 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0516035 |
| NFIB | nuclear factor I/B | -0.0509853 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0468757 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0465742 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.045869 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0425127 |
| RPS23 | ribosomal protein S23 | -0.042489 |
| MEOX2 | mesenchyme homeobox 2 | -0.0419978 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0416108 |
| RPS11 | ribosomal protein S11 | -0.0400483 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0393293 |
| PTK2 | protein tyrosine kinase 2 | -0.0386288 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0383383 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0376351 |
| RPS5 | ribosomal protein S5 | -0.0373393 |
| RPL34 | ribosomal protein L34 | -0.036034 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0356427 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0355925 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0349489 |
| TCF12 | transcription factor 12 | -0.0348819 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0348781 |
| FTL | ferritin, light polypeptide | -0.0346415 |
| HMGB1 | high mobility group box 1 | -0.0341347 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0340598 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0339472 |
| MEIS2 | Meis homeobox 2 | -0.0336225 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0330962 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0330919 |
| RPLP2 | ribosomal protein, large, P2 | -0.0328109 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0326328 |
| GNAS | GNAS complex locus | -0.0326086 |
| RPS19 | ribosomal protein S19 | -0.0323364 |
| RBM25 | RNA binding motif protein 25 | -0.032329 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317431 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.031559 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0314662 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0313883 |
| ZFHX3 | zinc finger homeobox 3 | -0.0308034 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0296196 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.0295794 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0291857 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0291268 |
| TUT4 | terminal uridylyl transferase 4 | -0.0289955 |
| RPL35A | ribosomal protein L35a | -0.0289267 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0286943 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0286476 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0285403 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0285276 |
| TRAF3 | TNF receptor-associated factor 3 | -0.02834 |
| RBM39 | RNA binding motif protein 39 | -0.0281529 |
| RTN4 | reticulon 4 | -0.0280369 |
| RPL8 | ribosomal protein L8 | -0.0280024 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0279365 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0276766 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0272384 |
| ENO1 | enolase 1, (alpha) | -0.0272234 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.027108 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0270198 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0269337 |
| RPL32 | ribosomal protein L32 | -0.0267556 |
| UBE3C | ubiquitin protein ligase E3C | -0.0266073 |
| CALU | calumenin | -0.0264943 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0264383 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.026417 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0262313 |
| ZRANB3 | zinc finger, RAN-binding domain containing 3 | -0.0259806 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0256777 |
| RPL39 | ribosomal protein L39 | -0.0255517 |
| FN1 | fibronectin 1 | -0.0254771 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0252819 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0250198 |
| CUX1 | cut-like homeobox 1 | -0.0248948 |
| PSMD1 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 | -0.0248494 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0244555 |
| CCNI | cyclin I | -0.0244518 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0241279 |
| USP34 | ubiquitin specific peptidase 34 | -0.0240805 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0240326 |
| SCFD2 | sec1 family domain containing 2 | -0.0240239 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0236881 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.023573 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0235577 |
| COG5 | component of oligomeric golgi complex 5 | -0.0235254 |
| REEP3 | receptor accessory protein 3 | -0.0234648 |
| BPTF | bromodomain PHD finger transcription factor | -0.0234432 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0233968 |
