| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.27699 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.276438 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.200212 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0889286 |
| PCBP2 | poly(rC) binding protein 2 | 0.0857611 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0821003 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0805582 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0766205 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0642796 |
| RPS2 | ribosomal protein S2 | 0.0632521 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0614432 |
| EZR | ezrin | 0.0571294 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0561887 |
| B2M | beta-2-microglobulin | 0.0543983 |
| RPS3 | ribosomal protein S3 | 0.0539009 |
| PTMA | prothymosin, alpha | 0.0539006 |
| TPM3 | tropomyosin 3 | 0.0517246 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0496132 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0494189 |
| SLK | STE20-like kinase | 0.0440316 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0436178 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0431771 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0428153 |
| SFTPA2 | surfactant protein A2 | 0.0412881 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0395355 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0394439 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0365403 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0359514 |
| PLEC | plectin | 0.0358135 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0357288 |
| SPAG9 | sperm associated antigen 9 | 0.0354442 |
| RIOK3 | RIO kinase 3 | 0.0345176 |
| SMC3 | structural maintenance of chromosomes 3 | 0.034444 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0342028 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0338994 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0334795 |
| DIAPH1 | diaphanous-related formin 1 | 0.0333943 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0327989 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0326786 |
| HDGF | hepatoma-derived growth factor | 0.0325326 |
| RCOR1 | REST corepressor 1 | 0.0321707 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0317864 |
| KIF5B | kinesin family member 5B | 0.0316074 |
| DSPP | dentin sialophosphoprotein | 0.0313945 |
| LDHA | lactate dehydrogenase A | 0.0308377 |
| TMSB4X | thymosin beta 4, X-linked | 0.0306457 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0305715 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0304424 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0304117 |
| YTHDC1 | YTH domain containing 1 | 0.0302195 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0299076 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0296747 |
| NUP58 | nucleoporin 58 | 0.0295871 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0294345 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0293426 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0293247 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0292084 |
| ARGLU1 | arginine and glutamate rich 1 | 0.028894 |
| CCNY | cyclin Y | 0.0284475 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0283943 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0282053 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0279853 |
| MCL1 | myeloid cell leukemia 1 | 0.0277881 |
| MATR3 | matrin 3 | 0.0277832 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0273924 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0272349 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0271143 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0269762 |
| ATF4 | activating transcription factor 4 | 0.0266364 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0259791 |
| CD164 | CD164 molecule, sialomucin | 0.025961 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0257081 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.025609 |
| LAMB3 | laminin, beta 3 | 0.0255139 |
| TUFT1 | tuftelin 1 | 0.0250899 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0245786 |
| MSN | moesin | 0.0245562 |
| RPS7 | ribosomal protein S7 | 0.0240859 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0238883 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0235224 |
| CCNL1 | cyclin L1 | 0.0234434 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0229712 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0229252 |
| ZFP36 | ZFP36 ring finger protein | 0.0228275 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0227718 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0227075 |
| VIM | vimentin | 0.0223779 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0221773 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0221458 |
| OXSR1 | oxidative stress responsive 1 | 0.0220559 |
| PNN | pinin, desmosome associated protein | 0.0220004 |
| OPTN | optineurin | 0.0219372 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0217554 |
| CORO1C | coronin, actin binding protein, 1C | 0.0216098 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0214102 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0214039 |
| RACK1 | receptor for activated C kinase 1 | 0.0212387 |
| BRD2 | bromodomain containing 2 | 0.0210096 |
| CLIC1 | chloride intracellular channel 1 | 0.0209307 |
| TMF1 | TATA element modulatory factor 1 | 0.0205244 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.203608 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.156478 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.148724 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.105633 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.10269 |
| S100A10 | S100 calcium binding protein A10 | -0.0991016 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0818057 |
| AHNAK | AHNAK nucleoprotein | -0.0740768 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0685048 |
| TXNRD1 | thioredoxin reductase 1 | -0.0663968 |
| MUC17 | mucin 17, cell surface associated | -0.0580922 |
| EFNA5 | ephrin-A5 | -0.057944 |
| EGFR | epidermal growth factor receptor | -0.054952 |
| DSG2 | desmoglein 2 | -0.0546308 |
| CD2AP | CD2-associated protein | -0.0531641 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0502143 |
| NPSR1 | neuropeptide S receptor 1 | -0.0498276 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0487251 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0478267 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0470988 |
| PRSS3 | protease, serine, 3 | -0.0470487 |
| ANXA2 | annexin A2 | -0.0461442 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0454251 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0448679 |
| DIAPH2 | diaphanous-related formin 2 | -0.0439576 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0429478 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0425211 |
| RPS24 | ribosomal protein S24 | -0.0419379 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0419193 |
| LMO7 | LIM domain 7 | -0.0419151 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0417993 |
| HMGA2 | high mobility group AT-hook 2 | -0.0417575 |
| RPLP0 | ribosomal protein, large, P0 | -0.0417444 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0414711 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0406543 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0401507 |
| HMGA1 | high mobility group AT-hook 1 | -0.0397487 |
| SLC38A2 | solute carrier family 38, member 2 | -0.039116 |
| ACTG1 | actin gamma 1 | -0.0390547 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0389563 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.038289 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0377468 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0376208 |
| RPL8 | ribosomal protein L8 | -0.0372027 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0371169 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0365055 |
| SDC4 | syndecan 4 | -0.036326 |
| KLF6 | Kruppel-like factor 6 | -0.0354463 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0351466 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0350402 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0346471 |
| EMP1 | epithelial membrane protein 1 | -0.0345383 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0345108 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0340245 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0337286 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0335063 |
| STK39 | serine threonine kinase 39 | -0.032909 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0327086 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0325108 |
| PRELID2 | PRELI domain containing 2 | -0.0324934 |
| CDK6 | cyclin-dependent kinase 6 | -0.0323776 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0320823 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0318858 |
| SBF2 | SET binding factor 2 | -0.031366 |
| EHBP1 | EH domain binding protein 1 | -0.03128 |
| RPL34 | ribosomal protein L34 | -0.0308081 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0299844 |
| RPS21 | ribosomal protein S21 | -0.0296712 |
| MXD1 | MAX dimerization protein 1 | -0.0295517 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0294285 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0288654 |
| ASPH | aspartate beta-hydroxylase | -0.028784 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0285746 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0282855 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.028252 |
| CDCP1 | CUB domain containing protein 1 | -0.028215 |
| CLMP | CXADR-like membrane protein | -0.0280562 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0280215 |
| NF1 | neurofibromin 1 | -0.0276048 |
| HDLBP | high density lipoprotein binding protein | -0.0275539 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.027296 |
| PARD3 | par-3 family cell polarity regulator | -0.0264516 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0263508 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.026279 |
| KRT19 | keratin 19, type I | -0.0261658 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0261565 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0261121 |
| RESF1 | retroelement silencing factor 1 | -0.0258562 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0256856 |
| PTK2 | protein tyrosine kinase 2 | -0.0255606 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0255128 |
| RASAL2 | RAS protein activator like 2 | -0.0252365 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0252217 |
| FAM3C | family with sequence similarity 3, member C | -0.025215 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0250668 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0249709 |
| TMEM263 | transmembrane protein 263 | -0.0249663 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0248544 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0248519 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0247466 |
