| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.17528 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0345138 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0334589 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0329858 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0304621 |
| TC2N | tandem C2 domains, nuclear | 0.0299384 |
| DSPP | dentin sialophosphoprotein | 0.0297905 |
| CFB | complement factor B | 0.0245954 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0233007 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0224596 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0216613 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0205724 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.020515 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0188991 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0182206 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0182075 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0169327 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | 0.0164447 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0162839 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0162511 |
| CANX | calnexin | 0.0161983 |
| EGFR | epidermal growth factor receptor | 0.0161124 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0161096 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0158629 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0158586 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0151393 |
| PGK1 | phosphoglycerate kinase 1 | 0.0149572 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0148152 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0144027 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0143516 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0142309 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.014047 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0138286 |
| KIF5B | kinesin family member 5B | 0.0137286 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0134982 |
| CEP250 | centrosomal protein 250kDa | 0.0133948 |
| EZR | ezrin | 0.0132976 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0132943 |
| ORMDL3 | ORMDL sphingolipid biosynthesis regulator 3 | 0.0132078 |
| CALR | calreticulin | 0.0131973 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0131735 |
| KIF16B | kinesin family member 16B | 0.0131505 |
| TOB1 | transducer of ERBB2, 1 | 0.0128669 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0128235 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0126273 |
| GOLGA2 | golgin A2 | 0.0125714 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0123637 |
| TMEM45B | transmembrane protein 45B | 0.0122759 |
| CLTC | clathrin, heavy chain (Hc) | 0.012179 |
| CD164 | CD164 molecule, sialomucin | 0.0121647 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.012146 |
| CCNL1 | cyclin L1 | 0.0119641 |
| GSDMB | gasdermin B | 0.0119323 |
| FAM13A | family with sequence similarity 13, member A | 0.0118006 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0117141 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0116531 |
| FADS2 | fatty acid desaturase 2 | 0.0116314 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0115812 |
| RRBP1 | ribosome binding protein 1 | 0.0114769 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.011458 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0113913 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0113552 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0111866 |
| ASPH | aspartate beta-hydroxylase | 0.0110646 |
| AHNAK | AHNAK nucleoprotein | 0.0109163 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.0105348 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0103917 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0103813 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0103326 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0102895 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0100698 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0100609 |
| LMAN1 | lectin, mannose-binding, 1 | 0.00990681 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.00980682 |
| CALU | calumenin | 0.00978865 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.00973826 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.00965051 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.00950836 |
| TMEM165 | transmembrane protein 165 | 0.00946148 |
| SETX | senataxin | 0.00936132 |
| ANKRD36 | ankyrin repeat domain 36 | 0.00935933 |
| OSMR | oncostatin M receptor | 0.00925286 |
| MLEC | malectin | 0.00924291 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.00921538 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.00920661 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.00918912 |
| SFTPA2 | surfactant protein A2 | 0.00914561 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.00910405 |
| SDCBP | syndecan binding protein (syntenin) | 0.00879723 |
| FGB | fibrinogen beta chain | 0.00876153 |
| CEP95 | centrosomal protein 95kDa | 0.00867261 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00865421 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.00862051 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00857346 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00855863 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.00854341 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.00854177 |
| TMSB4X | thymosin beta 4, X-linked | 0.00840854 |
| DUSP16 | dual specificity phosphatase 16 | 0.00839644 |
| CLU | clusterin | 0.00833277 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | -0.240087 |
| RPL23 | ribosomal protein L23 | -0.219096 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0825254 |
| ACTG1 | actin gamma 1 | -0.0620667 |
| CDK12 | cyclin-dependent kinase 12 | -0.0599694 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0526905 |
| RPL35A | ribosomal protein L35a | -0.051679 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0501526 |
| DTNA | dystrobrevin, alpha | -0.0465295 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.041611 |
| TMSB10 | thymosin beta 10 | -0.0405289 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0392972 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0376942 |
| PTMA | prothymosin, alpha | -0.0374977 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0369582 |
| RPS6 | ribosomal protein S6 | -0.0359237 |
| SP100 | SP100 nuclear antigen | -0.0353262 |
| POTEF | POTE ankyrin domain family, member F | -0.0340078 |
| RPL37A | ribosomal protein L37a | -0.0336693 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.033221 |
| RPS8 | ribosomal protein S8 | -0.0318404 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0317237 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0314588 |
| RPS3 | ribosomal protein S3 | -0.0314356 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.030375 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0303543 |
| CCND1 | cyclin D1 | -0.0293449 |
| RPL31 | ribosomal protein L31 | -0.0291662 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.028767 |
| RPS29 | ribosomal protein S29 | -0.0281978 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0279402 |
| PTK2 | protein tyrosine kinase 2 | -0.0279274 |
| PFDN4 | prefoldin subunit 4 | -0.0272602 |
| RPL12 | ribosomal protein L12 | -0.0267648 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0263052 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0254998 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | -0.0251518 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0251387 |
| RPL34 | ribosomal protein L34 | -0.025036 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0246006 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0241842 |
| JMJD1C | jumonji domain containing 1C | -0.0240265 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0239595 |
| RPL8 | ribosomal protein L8 | -0.0238772 |
| VMP1 | vacuole membrane protein 1 | -0.0237345 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0237153 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0236316 |
| RPS12 | ribosomal protein S12 | -0.0233633 |
| RBM47 | RNA binding motif protein 47 | -0.0232963 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0232435 |
| CUX1 | cut-like homeobox 1 | -0.0229626 |
| RPLP1 | ribosomal protein, large, P1 | -0.0228191 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0223382 |
| RPL37 | ribosomal protein L37 | -0.022076 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0218839 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0215813 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0215276 |
| RPS24 | ribosomal protein S24 | -0.021261 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0212358 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | -0.0212086 |
| GRB7 | growth factor receptor-bound protein 7 | -0.021185 |
| PARD3 | par-3 family cell polarity regulator | -0.0210771 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0210017 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0209383 |
| RPS19 | ribosomal protein S19 | -0.0206683 |
| TUBA1B | tubulin, alpha 1b | -0.0206525 |
| PLSCR1 | phospholipid scramblase 1 | -0.0203688 |
| KRT8 | keratin 8, type II | -0.0201244 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0200214 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0199279 |
| HLA-B | major histocompatibility complex, class I, B | -0.0198921 |
| RPS17 | ribosomal protein S17 | -0.0198888 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0196889 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0195858 |
| RPL28 | ribosomal protein L28 | -0.0195493 |
| RPS15 | ribosomal protein S15 | -0.0195482 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.019544 |
| RPL35 | ribosomal protein L35 | -0.0194814 |
| RPS16 | ribosomal protein S16 | -0.0194323 |
| RPL7A | ribosomal protein L7a | -0.0194198 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0193465 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0192214 |
| PMP22 | peripheral myelin protein 22 | -0.0191816 |
| INTS6 | integrator complex subunit 6 | -0.0191319 |
| NDRG1 | N-myc downstream regulated 1 | -0.019126 |
| EFNA5 | ephrin-A5 | -0.0186198 |
| DENND1A | DENN/MADD domain containing 1A | -0.0185725 |
| RPL9 | ribosomal protein L9 | -0.0185392 |
| MBD4 | methyl-CpG binding domain protein 4 | -0.0185067 |
| RAD51B | RAD51 paralog B | -0.0183452 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0183451 |
| RPL26 | ribosomal protein L26 | -0.0182528 |
| RPL36 | ribosomal protein L36 | -0.0180939 |
| EXOC4 | exocyst complex component 4 | -0.0176432 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0176372 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0176318 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0175905 |
| TPM4 | tropomyosin 4 | -0.0175097 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0174964 |
| RPL27A | ribosomal protein L27a | -0.0174579 |
