| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.16353 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0987738 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0946641 |
| FN1 | fibronectin 1 | 0.0821381 |
| CD109 | CD109 molecule | 0.0779098 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0772405 |
| NUP58 | nucleoporin 58 | 0.072292 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0707391 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0666602 |
| SFTPA2 | surfactant protein A2 | 0.0612009 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0577055 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0547333 |
| FMNL2 | formin-like 2 | 0.051694 |
| ENO1 | enolase 1, (alpha) | 0.0494673 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0487835 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0481528 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0471764 |
| RNF145 | ring finger protein 145 | 0.0435102 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0424714 |
| COPA | coatomer protein complex, subunit alpha | 0.0406376 |
| ASPH | aspartate beta-hydroxylase | 0.0403078 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0391657 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0387594 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0385725 |
| PHF21A | PHD finger protein 21A | 0.0383896 |
| ADM | adrenomedullin | 0.0380744 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0366541 |
| PRELID2 | PRELI domain containing 2 | 0.0361046 |
| PGK1 | phosphoglycerate kinase 1 | 0.0359645 |
| ZNF292 | zinc finger protein 292 | 0.0357454 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0357081 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0350913 |
| RNASE12 | ribonuclease, RNase A family, 12 (non-active) | 0.0350312 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0346282 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0333418 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0329579 |
| MT2A | metallothionein 2A | 0.0328157 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0327499 |
| FBXO7 | F-box protein 7 | 0.0325135 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0323995 |
| PLIN2 | perilipin 2 | 0.0323506 |
| ARRDC3 | arrestin domain containing 3 | 0.0318093 |
| CCNL1 | cyclin L1 | 0.0318022 |
| VEGFA | vascular endothelial growth factor A | 0.0312234 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0310692 |
| TPR | translocated promoter region, nuclear basket protein | 0.0309895 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0306534 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0305448 |
| ZNF638 | zinc finger protein 638 | 0.0304777 |
| VGF | VGF nerve growth factor inducible | 0.0304761 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0300449 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0296346 |
| CENPF | centromere protein F, 350/400kDa | 0.0295736 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0290825 |
| ZFP36 | ZFP36 ring finger protein | 0.0287497 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0283163 |
| B2M | beta-2-microglobulin | 0.0281268 |
| RPL3 | ribosomal protein L3 | 0.0281157 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0280047 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0278601 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0277312 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0273717 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0270832 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0266941 |
| CANX | calnexin | 0.0259509 |
| PTMS | parathymosin | 0.0258277 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.025755 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0254951 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0253791 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0252482 |
| TMEM178B | transmembrane protein 178B | 0.0251857 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0250613 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0249509 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0243252 |
| ZYX | zyxin | 0.0242245 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0239224 |
| NLGN1 | neuroligin 1 | 0.0239221 |
| MLEC | malectin | 0.0237419 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0233558 |
| NBAS | neuroblastoma amplified sequence | 0.0227836 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0225117 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0220992 |
| PCBP2 | poly(rC) binding protein 2 | 0.02208 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0216059 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0212999 |
| AFAP1 | actin filament associated protein 1 | 0.020874 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0207169 |
| CABIN1 | calcineurin binding protein 1 | 0.0206412 |
| RNF24 | ring finger protein 24 | 0.0204468 |
| SLK | STE20-like kinase | 0.0202305 |
| TMF1 | TATA element modulatory factor 1 | 0.0201755 |
| YBX1 | Y box binding protein 1 | 0.0200153 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0199803 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0198949 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.019623 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0196136 |
| MANBA | mannosidase, beta A, lysosomal | 0.0195426 |
| BRD2 | bromodomain containing 2 | 0.0195082 |
| RCOR1 | REST corepressor 1 | 0.0194902 |
| FRMD6 | FERM domain containing 6 | 0.0192724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.54477 |
| FMN1 | formin 1 | -0.104938 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0889189 |
| ACTG1 | actin gamma 1 | -0.0853848 |
| VIM | vimentin | -0.082806 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0565611 |
| IER3 | immediate early response 3 | -0.0544836 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0542377 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0487259 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0472039 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0469484 |
| INSIG1 | insulin induced gene 1 | -0.0462041 |
| PTCHD4 | patched domain containing 4 | -0.0458126 |
| CUX1 | cut-like homeobox 1 | -0.0445078 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0442732 |
| GDF15 | growth differentiation factor 15 | -0.0426093 |
| EGR1 | early growth response 1 | -0.0420147 |
| RPLP1 | ribosomal protein, large, P1 | -0.0418306 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0415964 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0413033 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0408114 |
| GNAS | GNAS complex locus | -0.0401223 |
| SRPK2 | SRSF protein kinase 2 | -0.0387216 |
| RHEB | Ras homolog enriched in brain | -0.03805 |
| RPLP0 | ribosomal protein, large, P0 | -0.037302 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0356114 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.034491 |
| GPC6 | glypican 6 | -0.0342187 |
| S100A6 | S100 calcium binding protein A6 | -0.0325818 |
| FUS | FUS RNA binding protein | -0.0324472 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0324308 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0324099 |
| CALU | calumenin | -0.0322876 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0317853 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0317697 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0310782 |
| FRMD5 | FERM domain containing 5 | -0.0309958 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0308643 |
| COG5 | component of oligomeric golgi complex 5 | -0.0308391 |
| TMSB10 | thymosin beta 10 | -0.0301511 |
| DENND1A | DENN/MADD domain containing 1A | -0.0297987 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0297381 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0292988 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0291652 |
| CTSD | cathepsin D | -0.0278355 |
| HMCN1 | hemicentin 1 | -0.0277719 |
| TPD52 | tumor protein D52 | -0.0268293 |
| EHBP1 | EH domain binding protein 1 | -0.0267858 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0264055 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0263932 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0260507 |
| NAV3 | neuron navigator 3 | -0.0260075 |
| LYST | lysosomal trafficking regulator | -0.0253202 |
| ATF6 | activating transcription factor 6 | -0.0249818 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0249668 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0247711 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0246625 |
| ACTN4 | actinin, alpha 4 | -0.0244971 |
| AHNAK | AHNAK nucleoprotein | -0.0242312 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0238246 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0237869 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0233683 |
| NHSL1 | NHS-like 1 | -0.0230098 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0229532 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0228836 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0227337 |
| CDK14 | cyclin-dependent kinase 14 | -0.0227278 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0224942 |
| LMNA | lamin A/C | -0.0222842 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0222086 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0222055 |
| HLA-B | major histocompatibility complex, class I, B | -0.0221648 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0220134 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0219004 |
| EXOC4 | exocyst complex component 4 | -0.021868 |
| INPP5F | inositol polyphosphate-5-phosphatase F | -0.0216549 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0215721 |
| S100A10 | S100 calcium binding protein A10 | -0.0213657 |
| PAX3 | paired box 3 | -0.0212733 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.021217 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0212096 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0211489 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0209911 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0209852 |
| RPL35A | ribosomal protein L35a | -0.0206475 |
| NAV1 | neuron navigator 1 | -0.0206207 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0204775 |
| POTEF | POTE ankyrin domain family, member F | -0.0204402 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.020382 |
| TLE4 | transducin-like enhancer of split 4 | -0.0203676 |
| JMJD1C | jumonji domain containing 1C | -0.0203353 |
| BPTF | bromodomain PHD finger transcription factor | -0.0202223 |
| OSMR | oncostatin M receptor | -0.0201256 |
| S100A9 | S100 calcium binding protein A9 | -0.0199718 |
| RPS24 | ribosomal protein S24 | -0.0197999 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0197528 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0197302 |
| SCFD2 | sec1 family domain containing 2 | -0.0197229 |
| VCL | vinculin | -0.0196852 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0196067 |
