| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.201062 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.138693 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.105595 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.105378 |
| LAMB3 | laminin, beta 3 | 0.0906612 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.090437 |
| VEGFA | vascular endothelial growth factor A | 0.0726334 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0622202 |
| PCBP2 | poly(rC) binding protein 2 | 0.0614009 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0556386 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.052995 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0523896 |
| CCNY | cyclin Y | 0.05186 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0473258 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.046826 |
| RCOR1 | REST corepressor 1 | 0.0463909 |
| CCNL1 | cyclin L1 | 0.0450563 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0446803 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0434924 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0432216 |
| FLNB | filamin B, beta | 0.042863 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0423146 |
| ANKRD11 | ankyrin repeat domain 11 | 0.040635 |
| NDRG1 | N-myc downstream regulated 1 | 0.0402577 |
| BRD2 | bromodomain containing 2 | 0.039743 |
| PRRC2C | proline-rich coiled-coil 2C | 0.03907 |
| MCL1 | myeloid cell leukemia 1 | 0.0389187 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0386394 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0380041 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0376208 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0370891 |
| SPAG9 | sperm associated antigen 9 | 0.0369453 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0369435 |
| TPM3 | tropomyosin 3 | 0.0363666 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0360207 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0355124 |
| DTNA | dystrobrevin, alpha | 0.0345164 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0332562 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0323192 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0318958 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0314523 |
| HDGF | hepatoma-derived growth factor | 0.0311917 |
| FOSL1 | FOS-like antigen 1 | 0.0310982 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.030469 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299211 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0296001 |
| B2M | beta-2-microglobulin | 0.0294186 |
| HELZ | helicase with zinc finger | 0.0287818 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0287629 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0282807 |
| NUP58 | nucleoporin 58 | 0.0281157 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0280717 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0278443 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0277014 |
| PNN | pinin, desmosome associated protein | 0.0271417 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0268855 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0268757 |
| TXNIP | thioredoxin interacting protein | 0.0267488 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0266015 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0264584 |
| DSPP | dentin sialophosphoprotein | 0.0263234 |
| C3 | complement component 3 | 0.0258742 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0258302 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0256467 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0254329 |
| CALR | calreticulin | 0.0253781 |
| RPL3 | ribosomal protein L3 | 0.0252525 |
| STC2 | stanniocalcin 2 | 0.0252202 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0252011 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0251716 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0250918 |
| MSN | moesin | 0.0249317 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0246711 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0244134 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0244104 |
| TGM2 | transglutaminase 2 | 0.0243954 |
| FAM13A | family with sequence similarity 13, member A | 0.0242612 |
| RIOK3 | RIO kinase 3 | 0.0240498 |
| SMAD3 | SMAD family member 3 | 0.0240418 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0238171 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.0237932 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0234053 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.023372 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0233612 |
| DIAPH1 | diaphanous-related formin 1 | 0.0229468 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0227105 |
| HPCAL1 | hippocalcin-like 1 | 0.0225651 |
| PTMA | prothymosin, alpha | 0.0225651 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0224468 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0220431 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0220194 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0219635 |
| ZFP36 | ZFP36 ring finger protein | 0.0217817 |
| MYO1B | myosin IB | 0.0213026 |
| TFG | TRK-fused gene | 0.0211319 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0209872 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0209359 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0209154 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0200184 |
| AFAP1 | actin filament associated protein 1 | 0.0199938 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.344658 |
| TMSB10 | thymosin beta 10 | -0.106231 |
| ACTG1 | actin gamma 1 | -0.099955 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0978283 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0866421 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0841709 |
| MT1X | metallothionein 1X | -0.0835737 |
| MMP7 | matrix metallopeptidase 7 | -0.072168 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0718247 |
| UBC | ubiquitin C | -0.0583467 |
| S100A6 | S100 calcium binding protein A6 | -0.0580075 |
| RPLP0 | ribosomal protein, large, P0 | -0.0564942 |
| HLA-B | major histocompatibility complex, class I, B | -0.0563469 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0557864 |
| RPLP1 | ribosomal protein, large, P1 | -0.0548953 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.053387 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.052416 |
| S100A10 | S100 calcium binding protein A10 | -0.0511532 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0503651 |
| ANXA2 | annexin A2 | -0.0477272 |
| RPL34 | ribosomal protein L34 | -0.0473584 |
| FTL | ferritin, light polypeptide | -0.0454834 |
| GNAS | GNAS complex locus | -0.0454118 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0443437 |
| RPL19 | ribosomal protein L19 | -0.0436305 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.043394 |
| AHNAK | AHNAK nucleoprotein | -0.0423634 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0417294 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0416725 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0407238 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0404701 |
| RPS21 | ribosomal protein S21 | -0.0397945 |
| IER3 | immediate early response 3 | -0.0395779 |
| RPS24 | ribosomal protein S24 | -0.0374002 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0373633 |
| KLF6 | Kruppel-like factor 6 | -0.0361098 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0359589 |
| CD2AP | CD2-associated protein | -0.0357013 |
| DSG2 | desmoglein 2 | -0.0355573 |
| VIM | vimentin | -0.0354856 |
| RPS29 | ribosomal protein S29 | -0.0335034 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0332493 |
| BICC1 | BicC family RNA binding protein 1 | -0.0332274 |
| KRT19 | keratin 19, type I | -0.0326136 |
| LASP1 | LIM and SH3 protein 1 | -0.0314493 |
| RPS23 | ribosomal protein S23 | -0.0313528 |
| EHBP1 | EH domain binding protein 1 | -0.0313502 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0312802 |
| RPL23 | ribosomal protein L23 | -0.0304504 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0304048 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0300591 |
| HMGA1 | high mobility group AT-hook 1 | -0.0300214 |
| SP100 | SP100 nuclear antigen | -0.0283885 |
| RPS8 | ribosomal protein S8 | -0.0282185 |
| ARF1 | ADP-ribosylation factor 1 | -0.0278369 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0277219 |
| TMEM263 | transmembrane protein 263 | -0.0268939 |
| RPL28 | ribosomal protein L28 | -0.0265888 |
| HDLBP | high density lipoprotein binding protein | -0.0263802 |
| EFNA5 | ephrin-A5 | -0.026332 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0262601 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0259295 |
| CDK12 | cyclin-dependent kinase 12 | -0.0257627 |
| HLA-E | major histocompatibility complex, class I, E | -0.0257613 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0257098 |
| LMO7 | LIM domain 7 | -0.0253754 |
| PATJ | PATJ crumbs cell polarity complex component | -0.025297 |
| OSMR | oncostatin M receptor | -0.0251216 |
| NRP1 | neuropilin 1 | -0.0251037 |
| RTN3 | reticulon 3 | -0.0244693 |
| TUBB | tubulin, beta class I | -0.0243024 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0239539 |
| FNIP1 | folliculin interacting protein 1 | -0.0235827 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0235246 |
| SDC4 | syndecan 4 | -0.0235013 |
| BPTF | bromodomain PHD finger transcription factor | -0.0235 |
| SYNRG | synergin, gamma | -0.023455 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0233346 |
| ASPH | aspartate beta-hydroxylase | -0.0230771 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0230698 |
| JMJD1C | jumonji domain containing 1C | -0.0230664 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.023054 |
| NRG3 | neuregulin 3 | -0.0229877 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0229068 |
| RPS5 | ribosomal protein S5 | -0.0228465 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0226377 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0225521 |
| RNF213 | ring finger protein 213 | -0.0225267 |
| RPL8 | ribosomal protein L8 | -0.0225193 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0224634 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0223108 |
| CCNI | cyclin I | -0.0222781 |
| DST | dystonin | -0.0221639 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0221165 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0218914 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0218526 |
| PCDH7 | protocadherin 7 | -0.0218523 |
| SGMS2 | sphingomyelin synthase 2 | -0.020834 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0204788 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0204147 |
