| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.429378 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0766728 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0601483 |
| LPIN1 | lipin 1 | 0.0569448 |
| FAM13A | family with sequence similarity 13, member A | 0.0552792 |
| HELZ | helicase with zinc finger | 0.0521273 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0504451 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.049021 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0478689 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0442116 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0421071 |
| VEGFA | vascular endothelial growth factor A | 0.0407527 |
| PTMA | prothymosin, alpha | 0.0400628 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.039861 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0380563 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0373844 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0346409 |
| RPL37A | ribosomal protein L37a | 0.0345976 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0341406 |
| PCBP2 | poly(rC) binding protein 2 | 0.0330262 |
| VIM | vimentin | 0.0327526 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0318177 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0309048 |
| POTEF | POTE ankyrin domain family, member F | 0.0306676 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.030536 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0303111 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0300134 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0295003 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0294326 |
| FOXO3 | forkhead box O3 | 0.0291968 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0291048 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0283054 |
| WDR43 | WD repeat domain 43 | 0.0279113 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0274518 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0273757 |
| WDR45B | WD repeat domain 45B | 0.0273633 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0272685 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0270749 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0267081 |
| MED13L | mediator complex subunit 13-like | 0.0259214 |
| YTHDC1 | YTH domain containing 1 | 0.0258312 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0258184 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.02558 |
| PKM | pyruvate kinase, muscle | 0.0255339 |
| RACK1 | receptor for activated C kinase 1 | 0.0255008 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0253245 |
| RPS2 | ribosomal protein S2 | 0.0252928 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.02493 |
| CCNL1 | cyclin L1 | 0.0246701 |
| NCKAP1 | NCK-associated protein 1 | 0.0245467 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0241862 |
| PHIP | pleckstrin homology domain interacting protein | 0.0241828 |
| B2M | beta-2-microglobulin | 0.0239514 |
| ZNF148 | zinc finger protein 148 | 0.0238356 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0237097 |
| XPO1 | exportin 1 | 0.0236466 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0235918 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.023066 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0228891 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0222739 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0220505 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0217467 |
| RPS17 | ribosomal protein S17 | 0.0215977 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0215582 |
| RPS12 | ribosomal protein S12 | 0.0212823 |
| TRIB2 | tribbles pseudokinase 2 | 0.0211024 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0209111 |
| MED13 | mediator complex subunit 13 | 0.0208281 |
| RPS3 | ribosomal protein S3 | 0.0207115 |
| MMP2 | matrix metallopeptidase 2 | 0.0206951 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0206088 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0202141 |
| RPS14 | ribosomal protein S14 | 0.0202104 |
| RBM25 | RNA binding motif protein 25 | 0.0199171 |
| MKI67 | marker of proliferation Ki-67 | 0.0198437 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.019513 |
| RPL3 | ribosomal protein L3 | 0.0194589 |
| ADM | adrenomedullin | 0.0191667 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0190799 |
| HMGB2 | high mobility group box 2 | 0.0190421 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0189169 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0188619 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0186808 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0185535 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0183949 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0183502 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0183026 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.018302 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0181259 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.018124 |
| MATR3 | matrin 3 | 0.0180793 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.018062 |
| PDS5B | PDS5 cohesin associated factor B | 0.0179886 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0179255 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0179179 |
| BBX | bobby sox homolog (Drosophila) | 0.0178555 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0178257 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0177605 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0177477 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0175661 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.229518 |
| LSAMP | limbic system-associated membrane protein | -0.171839 |
| SYT1 | synaptotagmin I | -0.0981982 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0962382 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0942182 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0826245 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0757388 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.073584 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0714313 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0700259 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0633601 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0619025 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0600469 |
| BPTF | bromodomain PHD finger transcription factor | -0.0600313 |
| ZNF804A | zinc finger protein 804A | -0.0593123 |
| FRMD4A | FERM domain containing 4A | -0.0574933 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0567791 |
| CADM2 | cell adhesion molecule 2 | -0.056003 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0548433 |
| NREP | neuronal regeneration related protein | -0.0548245 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0531892 |
| IGF2 | insulin-like growth factor 2 | -0.0519615 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.051415 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0492961 |
| ATRNL1 | attractin-like 1 | -0.049076 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0473552 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0459453 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0440968 |
| FMN1 | formin 1 | -0.0436776 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0428328 |
| GPC5 | glypican 5 | -0.0424941 |
| UNC5C | unc-5 homolog C (C. elegans) | -0.0417094 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0411496 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.0407471 |
| NBEA | neurobeachin | -0.0405616 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0399712 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0392745 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0392076 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0390887 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0384371 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0378103 |
| PCDH9 | protocadherin 9 | -0.0370773 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.036818 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0364855 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0359495 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0354972 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0354416 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0346685 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0337544 |
| COL3A1 | collagen, type III, alpha 1 | -0.0336894 |
| CUX1 | cut-like homeobox 1 | -0.0326057 |
| PRKCA | protein kinase C, alpha | -0.0315185 |
| KLHL13 | kelch-like family member 13 | -0.031256 |
| KCNIP4 | Kv channel interacting protein 4 | -0.0309938 |
| CNTN4 | contactin 4 | -0.0309306 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0308508 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | -0.0303028 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0297155 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0295608 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.029317 |
| PLAT | plasminogen activator, tissue | -0.02918 |
| EDEM3 | ER degradation enhancer, mannosidase alpha-like 3 | -0.0284453 |
| FHIT | fragile histidine triad | -0.0283109 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0277172 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0276828 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0276348 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0275991 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.026798 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0264417 |
| AEBP2 | AE binding protein 2 | -0.0264318 |
| RNF213 | ring finger protein 213 | -0.0263956 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0259585 |
| ZNF124 | zinc finger protein 124 | -0.0255806 |
| SMYD3 | SET and MYND domain containing 3 | -0.0254225 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0251712 |
| HDX | highly divergent homeobox | -0.0251251 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0251026 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0250034 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0249649 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0248666 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0248573 |
| CDK12 | cyclin-dependent kinase 12 | -0.0248002 |
| KCNT2 | potassium channel, sodium activated subfamily T, member 2 | -0.0246401 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0246398 |
| CDH13 | cadherin 13 | -0.0236469 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0236082 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.023546 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.023515 |
| DIAPH2 | diaphanous-related formin 2 | -0.0234153 |
| MAP1B | microtubule-associated protein 1B | -0.0231295 |
| ATXN1 | ataxin 1 | -0.02304 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0228866 |
| PHF14 | PHD finger protein 14 | -0.0227625 |
| ANGPT1 | angiopoietin 1 | -0.0226123 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.022599 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0225771 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0225087 |
| FOXP1 | forkhead box P1 | -0.0224178 |
| STC1 | stanniocalcin 1 | -0.0223834 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0223466 |
