| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0849961 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0675599 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0500367 |
| EGR1 | early growth response 1 | 0.0427421 |
| B2M | beta-2-microglobulin | 0.0426764 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0392319 |
| LMO7 | LIM domain 7 | 0.0376402 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0351241 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0331283 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.032838 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0320424 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0317812 |
| INTS6 | integrator complex subunit 6 | 0.0313458 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0288036 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0281557 |
| BRD2 | bromodomain containing 2 | 0.0249097 |
| SFTPA2 | surfactant protein A2 | 0.0246058 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.024409 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.023955 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0237864 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.023127 |
| VEGFA | vascular endothelial growth factor A | 0.0229579 |
| ARRDC3 | arrestin domain containing 3 | 0.0228491 |
| EZR | ezrin | 0.0220544 |
| PCBP2 | poly(rC) binding protein 2 | 0.0217563 |
| CCNL1 | cyclin L1 | 0.0216461 |
| MYO1E | myosin IE | 0.0214716 |
| COG6 | component of oligomeric golgi complex 6 | 0.0213272 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0212247 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0203425 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0202243 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0201744 |
| SPAG9 | sperm associated antigen 9 | 0.0201743 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0198695 |
| COPA | coatomer protein complex, subunit alpha | 0.0195712 |
| MORF4L2 | mortality factor 4 like 2 | 0.0194415 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0194206 |
| DUSP10 | dual specificity phosphatase 10 | 0.0194059 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0186367 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0178282 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.017553 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0170221 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0168512 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0167326 |
| CTSB | cathepsin B | 0.0164724 |
| ATF4 | activating transcription factor 4 | 0.0164255 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0164023 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0163941 |
| COG3 | component of oligomeric golgi complex 3 | 0.0162985 |
| GOLGB1 | golgin B1 | 0.0162695 |
| GOLGA2 | golgin A2 | 0.0161524 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0160847 |
| VMP1 | vacuole membrane protein 1 | 0.0159967 |
| FOSL2 | FOS-like antigen 2 | 0.0158968 |
| ZNF841 | zinc finger protein 841 | 0.0156955 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0156298 |
| CDHR2 | cadherin-related family member 2 | 0.0155737 |
| DHFR | dihydrofolate reductase | 0.0155164 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0153843 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0153539 |
| ZFP36 | ZFP36 ring finger protein | 0.0152797 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0148165 |
| DSPP | dentin sialophosphoprotein | 0.014793 |
| CALR | calreticulin | 0.014547 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.0144243 |
| TMF1 | TATA element modulatory factor 1 | 0.0143243 |
| ADM | adrenomedullin | 0.0143172 |
| IER2 | immediate early response 2 | 0.0141748 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0140591 |
| RPL21 | ribosomal protein L21 | 0.013997 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0139646 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0138875 |
| RNF149 | ring finger protein 149 | 0.0138392 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0138331 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0137505 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0136929 |
| CENPF | centromere protein F, 350/400kDa | 0.0136277 |
| FDPS | farnesyl diphosphate synthase | 0.0135963 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0134321 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0134147 |
| CALU | calumenin | 0.0133063 |
| ADIPOR2 | adiponectin receptor 2 | 0.0131811 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.012973 |
| GOLGA4 | golgin A4 | 0.0129677 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.0129402 |
| CLDN4 | claudin 4 | 0.0129282 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0129075 |
| PMM2 | phosphomannomutase 2 | 0.0127243 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.0127098 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0126896 |
| TRIB1 | tribbles pseudokinase 1 | 0.0125926 |
| FNIP1 | folliculin interacting protein 1 | 0.0125922 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0123403 |
| PGM3 | phosphoglucomutase 3 | 0.0123395 |
| ZNF638 | zinc finger protein 638 | 0.0122163 |
| MPZL3 | myelin protein zero-like 3 | 0.0120453 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0119692 |
| UBN2 | ubinuclein 2 | 0.011934 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0118526 |
| HELZ | helicase with zinc finger | 0.0116227 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.121806 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.117975 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.110422 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.109566 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.10248 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0993818 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0951733 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0858558 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0843 |
| RUNX1 | runt-related transcription factor 1 | -0.0816491 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0769265 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.074346 |
| HLA-B | major histocompatibility complex, class I, B | -0.0701588 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0688389 |
| XAF1 | XIAP associated factor 1 | -0.0685279 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0663076 |
| PRKCA | protein kinase C, alpha | -0.0647783 |
| RNF213 | ring finger protein 213 | -0.0640446 |
| LCN2 | lipocalin 2 | -0.0634999 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0633701 |
| LYZ | lysozyme | -0.0608322 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0598794 |
| MX1 | MX dynamin-like GTPase 1 | -0.0595984 |
| RIGI | RNA sensor RIG-I | -0.0584261 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0568941 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0565917 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0558294 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.055566 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0547684 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0537777 |
| MSI2 | musashi RNA-binding protein 2 | -0.053581 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0529748 |
| NCKAP5 | NCK-associated protein 5 | -0.050841 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0506071 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.049746 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0490267 |
| RAD51B | RAD51 paralog B | -0.0487242 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0481409 |
| MX2 | MX dynamin-like GTPase 2 | -0.0469852 |
| NPSR1 | neuropeptide S receptor 1 | -0.0466631 |
| EPHB2 | EPH receptor B2 | -0.0453339 |
| SP100 | SP100 nuclear antigen | -0.043707 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0434367 |
| PHF3 | PHD finger protein 3 | -0.0433869 |
| ITGA6 | integrin, alpha 6 | -0.0433375 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0430843 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0427215 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.042628 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0423519 |
| PLSCR1 | phospholipid scramblase 1 | -0.0422967 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0412505 |
| ATP11A | ATPase, class VI, type 11A | -0.0411103 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0392429 |
| SSH2 | slingshot protein phosphatase 2 | -0.0388193 |
| NF1 | neurofibromin 1 | -0.0387065 |
| SPATA13 | spermatogenesis associated 13 | -0.0386091 |
| TXNRD1 | thioredoxin reductase 1 | -0.037982 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0379557 |
| PTK2 | protein tyrosine kinase 2 | -0.037071 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0365427 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0361876 |
| TRERF1 | transcriptional regulating factor 1 | -0.0360614 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0348968 |
| ETV6 | ets variant 6 | -0.0348362 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0345034 |
| VCL | vinculin | -0.0344921 |
| PTGR1 | prostaglandin reductase 1 | -0.034299 |
| PERP | PERP, TP53 apoptosis effector | -0.0339016 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0332528 |
| ATXN1 | ataxin 1 | -0.0326733 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0325691 |
| MAP7 | microtubule-associated protein 7 | -0.0324997 |
| SQSTM1 | sequestosome 1 | -0.0322249 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0320593 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0318166 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0303488 |
| MEIS2 | Meis homeobox 2 | -0.0303108 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0303093 |
| FMN1 | formin 1 | -0.0300542 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298228 |
| ASPH | aspartate beta-hydroxylase | -0.0297568 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0297 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0296199 |
| ANXA4 | annexin A4 | -0.0295206 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0294508 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0293165 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0292864 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0292703 |
| FHIT | fragile histidine triad | -0.0292283 |
| FOXP1 | forkhead box P1 | -0.0291936 |
| CLYBL | citrate lyase beta like | -0.0291534 |
| SMYD3 | SET and MYND domain containing 3 | -0.0290502 |
| PCED1B | PC-esterase domain containing 1B | -0.028858 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0286679 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0285556 |
| MECOM | MDS1 and EVI1 complex locus | -0.0284461 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0282205 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0278359 |
| RNF43 | ring finger protein 43 | -0.0271198 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0270415 |
