| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.136118 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.132941 |
| COL6A3 | collagen, type VI, alpha 3 | 0.107454 |
| CANX | calnexin | 0.0992391 |
| STC1 | stanniocalcin 1 | 0.0949848 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0886997 |
| MT2A | metallothionein 2A | 0.0761729 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0695989 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0665698 |
| NDRG1 | N-myc downstream regulated 1 | 0.064111 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0600879 |
| ENO1 | enolase 1, (alpha) | 0.059437 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.059377 |
| PGK1 | phosphoglycerate kinase 1 | 0.0505603 |
| TXNIP | thioredoxin interacting protein | 0.0484983 |
| MSN | moesin | 0.0482831 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0475293 |
| LOXL2 | lysyl oxidase-like 2 | 0.0474865 |
| SMAD3 | SMAD family member 3 | 0.0466582 |
| LDHA | lactate dehydrogenase A | 0.0456552 |
| ATP13A3 | ATPase type 13A3 | 0.0455978 |
| CALR | calreticulin | 0.0454864 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0448997 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0445796 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0426818 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0421345 |
| TPM3 | tropomyosin 3 | 0.0413906 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0409033 |
| VIM | vimentin | 0.0398907 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0392868 |
| AHNAK | AHNAK nucleoprotein | 0.0386459 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0382445 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0380208 |
| APP | amyloid beta (A4) precursor protein | 0.0377835 |
| CD44 | CD44 molecule (Indian blood group) | 0.0377732 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0366069 |
| SBF2 | SET binding factor 2 | 0.0363522 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0351237 |
| TLN1 | talin 1 | 0.0350676 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0342925 |
| EGFR | epidermal growth factor receptor | 0.0341429 |
| ZNF841 | zinc finger protein 841 | 0.0337524 |
| MKI67 | marker of proliferation Ki-67 | 0.032873 |
| MYOF | myoferlin | 0.0326461 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0323139 |
| CDK19 | cyclin-dependent kinase 19 | 0.0322925 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0318699 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0318651 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0316866 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0310308 |
| GOLGA4 | golgin A4 | 0.0303954 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0303868 |
| RASA2 | RAS p21 protein activator 2 | 0.029891 |
| CALD1 | caldesmon 1 | 0.0298768 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0298433 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0288302 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0285621 |
| WDR26 | WD repeat domain 26 | 0.0285012 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0279294 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0276313 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0273245 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0271649 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0271569 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0269869 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0266997 |
| CENPF | centromere protein F, 350/400kDa | 0.0266821 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0265431 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0264249 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0262615 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0262131 |
| COL5A1 | collagen, type V, alpha 1 | 0.0256559 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0252749 |
| LRRC49 | leucine rich repeat containing 49 | 0.0252612 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0251672 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0251609 |
| OSMR | oncostatin M receptor | 0.0250709 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0250306 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0248486 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.024502 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0243744 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0242089 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0241377 |
| COPA | coatomer protein complex, subunit alpha | 0.0240481 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0240272 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.023872 |
| ZNF395 | zinc finger protein 395 | 0.0238456 |
| CLTC | clathrin, heavy chain (Hc) | 0.0238303 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0238152 |
| CLIC1 | chloride intracellular channel 1 | 0.0237862 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0237164 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0236826 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0235914 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0235108 |
| GOLGB1 | golgin B1 | 0.0234033 |
| OGA | O-GlcNAcase | 0.0233702 |
| CORO1C | coronin, actin binding protein, 1C | 0.0233349 |
| TMSB4X | thymosin beta 4, X-linked | 0.0232785 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0232231 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.02291 |
| ZNF292 | zinc finger protein 292 | 0.0228866 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.287753 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.151174 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.136569 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.102553 |
| GRB10 | growth factor receptor-bound protein 10 | -0.101358 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0785459 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0684089 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.061498 |
| FN1 | fibronectin 1 | -0.0603884 |
| TMSB10 | thymosin beta 10 | -0.0583945 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0490443 |
| FTL | ferritin, light polypeptide | -0.0489981 |
| SQSTM1 | sequestosome 1 | -0.0428818 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0415322 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.039438 |
| AUTS2 | autism susceptibility candidate 2 | -0.0391451 |
| PTCHD4 | patched domain containing 4 | -0.0365198 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0358009 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0354164 |
| RPS8 | ribosomal protein S8 | -0.0348489 |
| RPLP1 | ribosomal protein, large, P1 | -0.0348291 |
| RPL28 | ribosomal protein L28 | -0.0346731 |
| KYNU | kynureninase | -0.0346373 |
| HLA-B | major histocompatibility complex, class I, B | -0.0341515 |
| POTEF | POTE ankyrin domain family, member F | -0.0328767 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.031902 |
| NCOA7 | nuclear receptor coactivator 7 | -0.031365 |
| EGR1 | early growth response 1 | -0.0312665 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0310524 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0305116 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0303392 |
| DST | dystonin | -0.0300508 |
| ZNF804A | zinc finger protein 804A | -0.0292534 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0289117 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0286603 |
| RPL34 | ribosomal protein L34 | -0.0283613 |
| GLCCI1 | glucocorticoid induced 1 | -0.0277829 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0272442 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0269268 |
| TENM3 | teneurin transmembrane protein 3 | -0.0266757 |
| INTS6 | integrator complex subunit 6 | -0.0266655 |
| ACTG1 | actin gamma 1 | -0.0265774 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0265695 |
| VCL | vinculin | -0.0264474 |
| RPL27A | ribosomal protein L27a | -0.0261452 |
| RPS24 | ribosomal protein S24 | -0.0260693 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0260332 |
| CDK14 | cyclin-dependent kinase 14 | -0.0259628 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0253408 |
| RPL35A | ribosomal protein L35a | -0.0251393 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0250152 |
| AHR | aryl hydrocarbon receptor | -0.0249978 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0245533 |
| IER3 | immediate early response 3 | -0.0243037 |
| TXNRD1 | thioredoxin reductase 1 | -0.0236529 |
| RIGI | RNA sensor RIG-I | -0.0235563 |
| NLGN1 | neuroligin 1 | -0.0234725 |
| SUMF1 | sulfatase modifying factor 1 | -0.0234711 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0230641 |
| RPLP0 | ribosomal protein, large, P0 | -0.0230639 |
| UBAP2 | ubiquitin associated protein 2 | -0.0230564 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0230459 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0229567 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0229228 |
| JUN | jun proto-oncogene | -0.02289 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0224704 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0222393 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0218448 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0217464 |
| RPS19 | ribosomal protein S19 | -0.0215858 |
| SYT1 | synaptotagmin I | -0.0214384 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.021415 |
| CDK13 | cyclin-dependent kinase 13 | -0.0207252 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0205107 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.02041 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.020381 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | -0.0203416 |
| LRRC23 | leucine rich repeat containing 23 | -0.0201538 |
| TUBB | tubulin, beta class I | -0.0200328 |
| RPL32 | ribosomal protein L32 | -0.0200203 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0198697 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0197564 |
| ASTN2 | astrotactin 2 | -0.0197145 |
| NIBAN1 | niban apoptosis regulator 1 | -0.0195801 |
| GNAS | GNAS complex locus | -0.0192469 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0191506 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0190547 |
| CUX1 | cut-like homeobox 1 | -0.0188985 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0188558 |
| DGKI | diacylglycerol kinase, iota | -0.0188051 |
| DTNA | dystrobrevin, alpha | -0.0187937 |
| PARD3 | par-3 family cell polarity regulator | -0.0187572 |
| CEP128 | centrosomal protein 128kDa | -0.0187294 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0185488 |
| PTK2 | protein tyrosine kinase 2 | -0.0185069 |
| RPS20 | ribosomal protein S20 | -0.0184947 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0184539 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0184127 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0181618 |
| TUBA1B | tubulin, alpha 1b | -0.0181528 |
