| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.159265 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.116896 |
| DSCAM | Down syndrome cell adhesion molecule | 0.100963 |
| GOLGA4 | golgin A4 | 0.100445 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0858715 |
| CANX | calnexin | 0.0733509 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0728138 |
| PRELID2 | PRELI domain containing 2 | 0.0671404 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0622469 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.062133 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0613159 |
| OGA | O-GlcNAcase | 0.0607644 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.060379 |
| PCBP2 | poly(rC) binding protein 2 | 0.0578006 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0560027 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0551011 |
| TMF1 | TATA element modulatory factor 1 | 0.0547708 |
| AHNAK | AHNAK nucleoprotein | 0.0540138 |
| ZNF638 | zinc finger protein 638 | 0.0508775 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0507103 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0486853 |
| HELZ | helicase with zinc finger | 0.0482827 |
| ZNF292 | zinc finger protein 292 | 0.0471335 |
| RBM39 | RNA binding motif protein 39 | 0.0458654 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0457847 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0444887 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0442261 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0438999 |
| YEATS2 | YEATS domain containing 2 | 0.0438278 |
| NUP58 | nucleoporin 58 | 0.0430955 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0427129 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0425719 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0417584 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0416721 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.041008 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0408582 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0403849 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.040071 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.039707 |
| MATR3 | matrin 3 | 0.0385554 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0384781 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0384115 |
| GOLGA2 | golgin A2 | 0.0376012 |
| ARF4 | ADP-ribosylation factor 4 | 0.0375602 |
| SUCO | SUN domain containing ossification factor | 0.037436 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.037354 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0370566 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0367353 |
| TMEM41B | transmembrane protein 41B | 0.0365741 |
| FDPS | farnesyl diphosphate synthase | 0.036397 |
| SRP54 | signal recognition particle 54kDa | 0.0361749 |
| ZNF654 | zinc finger protein 654 | 0.0361139 |
| PGK1 | phosphoglycerate kinase 1 | 0.0359535 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0358659 |
| COPA | coatomer protein complex, subunit alpha | 0.0357359 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0353453 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.035141 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0350539 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0346741 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0346399 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0342207 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0339105 |
| RIOK3 | RIO kinase 3 | 0.0338677 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0338612 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0335161 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.033476 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0333062 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0330294 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0329411 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0329144 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0328957 |
| YTHDC1 | YTH domain containing 1 | 0.0327992 |
| RLF | rearranged L-myc fusion | 0.0327317 |
| TPR | translocated promoter region, nuclear basket protein | 0.0326247 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0326126 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0323256 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0323149 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0321322 |
| PCM1 | pericentriolar material 1 | 0.0320758 |
| SPAG9 | sperm associated antigen 9 | 0.0319721 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0319481 |
| TXNRD1 | thioredoxin reductase 1 | 0.0317959 |
| CDK19 | cyclin-dependent kinase 19 | 0.03144 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0314188 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0311316 |
| USP37 | ubiquitin specific peptidase 37 | 0.0307894 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0307095 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0306681 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0305152 |
| WDR26 | WD repeat domain 26 | 0.0302601 |
| INSIG2 | insulin induced gene 2 | 0.0300541 |
| SON | SON DNA binding protein | 0.0299627 |
| RNF24 | ring finger protein 24 | 0.0299315 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.029929 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0299216 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0297245 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0297172 |
| WDR45B | WD repeat domain 45B | 0.0295153 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0291393 |
| GOLGB1 | golgin B1 | 0.0291049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.217594 |
| PTMA | prothymosin, alpha | -0.158711 |
| FAT1 | FAT atypical cadherin 1 | -0.150939 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114236 |
| TMSB10 | thymosin beta 10 | -0.100384 |
| NDRG1 | N-myc downstream regulated 1 | -0.0816563 |
| POTEF | POTE ankyrin domain family, member F | -0.0779653 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0693633 |
| PKM | pyruvate kinase, muscle | -0.0678947 |
| RPS6 | ribosomal protein S6 | -0.0652408 |
| EGR1 | early growth response 1 | -0.0648934 |
| ACTG1 | actin gamma 1 | -0.0573611 |
| TUBA1B | tubulin, alpha 1b | -0.0554136 |
| RPS8 | ribosomal protein S8 | -0.0532041 |
| INTS6 | integrator complex subunit 6 | -0.0517103 |
| RPL35A | ribosomal protein L35a | -0.0485367 |
| EGFR | epidermal growth factor receptor | -0.0455487 |
| WWOX | WW domain containing oxidoreductase | -0.0430026 |
| RPS13 | ribosomal protein S13 | -0.0394843 |
| RPS25 | ribosomal protein S25 | -0.0393736 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0390444 |
| HMGA1 | high mobility group AT-hook 1 | -0.0390261 |
| HMGA2 | high mobility group AT-hook 2 | -0.0386708 |
| CCND1 | cyclin D1 | -0.0366968 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0356149 |
| RPLP1 | ribosomal protein, large, P1 | -0.0345729 |
| FHIT | fragile histidine triad | -0.0341751 |
| RPL31 | ribosomal protein L31 | -0.0326785 |
| RPLP2 | ribosomal protein, large, P2 | -0.0322753 |
| RPL37A | ribosomal protein L37a | -0.032062 |
| RPS23 | ribosomal protein S23 | -0.0315301 |
| LRRC23 | leucine rich repeat containing 23 | -0.0312968 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0310986 |
| RPS15 | ribosomal protein S15 | -0.0307565 |
| RPS10 | ribosomal protein S10 | -0.0297918 |
| RPL19 | ribosomal protein L19 | -0.0297458 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.029072 |
| S100A10 | S100 calcium binding protein A10 | -0.0289426 |
| CADPS | Ca++-dependent secretion activator | -0.0287534 |
| RPL34 | ribosomal protein L34 | -0.0282737 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.027333 |
| ITGB4 | integrin, beta 4 | -0.0273107 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0273049 |
| HMGB1 | high mobility group box 1 | -0.0272938 |
| RPS29 | ribosomal protein S29 | -0.0272008 |
| RPS24 | ribosomal protein S24 | -0.0271829 |
| RPS11 | ribosomal protein S11 | -0.0267001 |
| SERINC5 | serine incorporator 5 | -0.0262259 |
| MSI2 | musashi RNA-binding protein 2 | -0.026181 |
| RPS17 | ribosomal protein S17 | -0.0259271 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0257784 |
| MT2A | metallothionein 2A | -0.0256325 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0254839 |
| HLA-B | major histocompatibility complex, class I, B | -0.0254609 |
| RPL38 | ribosomal protein L38 | -0.0253289 |
| RPS19 | ribosomal protein S19 | -0.0249059 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0245194 |
| HLA-A | major histocompatibility complex, class I, A | -0.0244309 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0243576 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0242677 |
| PFN1 | profilin 1 | -0.0242289 |
| HELLS | helicase, lymphoid-specific | -0.0235555 |
| ASPH | aspartate beta-hydroxylase | -0.0235325 |
| RPL5 | ribosomal protein L5 | -0.0232421 |
| FUS | FUS RNA binding protein | -0.0229626 |
| RPL8 | ribosomal protein L8 | -0.0227753 |
| NOP56 | NOP56 ribonucleoprotein | -0.0225218 |
| LDHB | lactate dehydrogenase B | -0.0224645 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0222326 |
| KRT8 | keratin 8, type II | -0.0219023 |
| RCC1 | regulator of chromosome condensation 1 | -0.0216925 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0216181 |
| RPL37 | ribosomal protein L37 | -0.0215946 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0214353 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0210884 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.0209664 |
| TUBB | tubulin, beta class I | -0.020527 |
| CDCP1 | CUB domain containing protein 1 | -0.0205242 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0204889 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0203362 |
| FRMD5 | FERM domain containing 5 | -0.0202723 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0202342 |
| RPL9 | ribosomal protein L9 | -0.0201568 |
| RPS5 | ribosomal protein S5 | -0.0198865 |
| RPS21 | ribosomal protein S21 | -0.0197579 |
| EHBP1 | EH domain binding protein 1 | -0.0196865 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0194174 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0193754 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0193557 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0192419 |
| RPS27A | ribosomal protein S27a | -0.0189979 |
| S100A9 | S100 calcium binding protein A9 | -0.0189236 |
| KPNB1 | karyopherin (importin) beta 1 | -0.018782 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0185834 |
| KLHL29 | kelch-like family member 29 | -0.0185822 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0185457 |
| RPL28 | ribosomal protein L28 | -0.0183742 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0183481 |
| KRT18 | keratin 18, type I | -0.018335 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0182261 |
