| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.117829 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0945755 |
| TMSB4X | thymosin beta 4, X-linked | 0.0925901 |
| LAMB3 | laminin, beta 3 | 0.0910462 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0838567 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0825905 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0719201 |
| B2M | beta-2-microglobulin | 0.0681244 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0679362 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0672644 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0633073 |
| APP | amyloid beta (A4) precursor protein | 0.0604974 |
| MATR3 | matrin 3 | 0.0564678 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0527136 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0477016 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0466207 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0448033 |
| PTMA | prothymosin, alpha | 0.0440121 |
| RACK1 | receptor for activated C kinase 1 | 0.0438189 |
| H1-0 | H1.0 linker histone | 0.0412248 |
| FLNA | filamin A, alpha | 0.040777 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.039045 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0373031 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.037146 |
| SET | SET nuclear proto-oncogene | 0.0370099 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0366905 |
| GOLGA4 | golgin A4 | 0.0366723 |
| RPS2 | ribosomal protein S2 | 0.0364571 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0357941 |
| SFTPA2 | surfactant protein A2 | 0.0355939 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0355914 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0334599 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0333466 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0323344 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0320077 |
| RNF145 | ring finger protein 145 | 0.0317596 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0311494 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.030908 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0308678 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0305479 |
| RPS3 | ribosomal protein S3 | 0.0302305 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0301592 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0301256 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.029496 |
| RPS7 | ribosomal protein S7 | 0.0287907 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0287053 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0282016 |
| TPR | translocated promoter region, nuclear basket protein | 0.0274959 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0274383 |
| KIF5B | kinesin family member 5B | 0.0271978 |
| CALR | calreticulin | 0.026962 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0269556 |
| CANX | calnexin | 0.0266669 |
| MKI67 | marker of proliferation Ki-67 | 0.0266307 |
| AFDN | afadin, adherens junction formation factor | 0.0264902 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0264854 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0262248 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0261217 |
| RPL3 | ribosomal protein L3 | 0.0259348 |
| PLEC | plectin | 0.0257597 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0257494 |
| WDR43 | WD repeat domain 43 | 0.0255481 |
| RPL13A | ribosomal protein L13a | 0.0254371 |
| RPL37A | ribosomal protein L37a | 0.0252232 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0252203 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.025212 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0250806 |
| PNN | pinin, desmosome associated protein | 0.0248026 |
| RPS3A | ribosomal protein S3A | 0.0247196 |
| ATF4 | activating transcription factor 4 | 0.0247069 |
| NCKAP1 | NCK-associated protein 1 | 0.0243261 |
| RPS27A | ribosomal protein S27a | 0.023984 |
| PCBP2 | poly(rC) binding protein 2 | 0.0237569 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0235873 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0235186 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0233673 |
| RANBP2 | RAN binding protein 2 | 0.0232766 |
| FNBP1L | formin binding protein 1-like | 0.0232156 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0229532 |
| CCDC93 | coiled-coil domain containing 93 | 0.0228905 |
| CCNL1 | cyclin L1 | 0.0228691 |
| KRT7 | keratin 7, type II | 0.0225185 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0224822 |
| CASC3 | cancer susceptibility candidate 3 | 0.0224409 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.022073 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0220638 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0216957 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.021672 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0215795 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0215312 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0212258 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0210661 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0208347 |
| BRD2 | bromodomain containing 2 | 0.0206589 |
| TEX10 | testis expressed 10 | 0.0205836 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0202949 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0201773 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0198694 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0196676 |
| RPL26 | ribosomal protein L26 | 0.0186939 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.37175 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.159597 |
| ACTG1 | actin gamma 1 | -0.107063 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0813557 |
| ASPH | aspartate beta-hydroxylase | -0.0785568 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.073108 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0681595 |
| FHIT | fragile histidine triad | -0.0679179 |
| POTEF | POTE ankyrin domain family, member F | -0.0659138 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0649634 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0571572 |
| BPTF | bromodomain PHD finger transcription factor | -0.0566234 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0551308 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0512737 |
| MACROD2 | MACRO domain containing 2 | -0.0512018 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0508343 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.049071 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0474 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0473405 |
| HMGA1 | high mobility group AT-hook 1 | -0.0471123 |
| NDRG1 | N-myc downstream regulated 1 | -0.0466385 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0453104 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0446491 |
| DIAPH3 | diaphanous-related formin 3 | -0.044307 |
| TUBA1B | tubulin, alpha 1b | -0.0442447 |
| RAD51B | RAD51 paralog B | -0.0438311 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.04297 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0414291 |
| PRELID2 | PRELI domain containing 2 | -0.0411801 |
| NF1 | neurofibromin 1 | -0.0399494 |
| ITGB8 | integrin, beta 8 | -0.0399398 |
| RPLP0 | ribosomal protein, large, P0 | -0.0398346 |
| S100A10 | S100 calcium binding protein A10 | -0.0395942 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0394359 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0393394 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0385358 |
| CD44 | CD44 molecule (Indian blood group) | -0.0382408 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.037382 |
| WWOX | WW domain containing oxidoreductase | -0.0369321 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0363721 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0362778 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0362439 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0362236 |
| TXNRD1 | thioredoxin reductase 1 | -0.0359092 |
| SVIL | supervillin | -0.0358668 |
| SMYD3 | SET and MYND domain containing 3 | -0.035753 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0352857 |
| FTL | ferritin, light polypeptide | -0.0344934 |
| TAOK1 | TAO kinase 1 | -0.0344553 |
| RPL32 | ribosomal protein L32 | -0.0344488 |
| VCL | vinculin | -0.0342414 |
| CDCP1 | CUB domain containing protein 1 | -0.0339295 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0333762 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0333344 |
| WWC1 | WW and C2 domain containing 1 | -0.0330942 |
| EXOC4 | exocyst complex component 4 | -0.0330193 |
| SBF2 | SET binding factor 2 | -0.0328293 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0326006 |
| UPP1 | uridine phosphorylase 1 | -0.0325708 |
| SUMF1 | sulfatase modifying factor 1 | -0.0317946 |
| BBX | bobby sox homolog (Drosophila) | -0.0315953 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0315634 |
| TPM4 | tropomyosin 4 | -0.0313501 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0305202 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0304076 |
| JMJD1C | jumonji domain containing 1C | -0.0300765 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0300406 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0297634 |
| CCND1 | cyclin D1 | -0.0292512 |
| DSG2 | desmoglein 2 | -0.028831 |
| CD2AP | CD2-associated protein | -0.0287536 |
| RPS11 | ribosomal protein S11 | -0.0286013 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0285199 |
| RPS6 | ribosomal protein S6 | -0.0285148 |
| TUBB | tubulin, beta class I | -0.0284289 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0281774 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0277972 |
| DEK | DEK proto-oncogene | -0.0275965 |
| PTK2 | protein tyrosine kinase 2 | -0.0274797 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0274137 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0268008 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0263129 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0262725 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0261124 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0260587 |
| RSF1 | remodeling and spacing factor 1 | -0.0260145 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.025875 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0258683 |
| SETD5 | SET domain containing 5 | -0.0257227 |
| ACTN4 | actinin, alpha 4 | -0.0256335 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0248383 |
| SEPTIN9 | septin 9 | -0.0248147 |
| PCED1B | PC-esterase domain containing 1B | -0.0247507 |
| CDK13 | cyclin-dependent kinase 13 | -0.024661 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0246235 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0244644 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0242684 |
| RPS10 | ribosomal protein S10 | -0.024248 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.024176 |
| BICC1 | BicC family RNA binding protein 1 | -0.0239895 |
