Osimertinib (mesylate)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.17649
ELL2 elongation factor, RNA polymerase II, 2 0.142718
FAM13A family with sequence similarity 13, member A 0.104754
ERRFI1 ERBB receptor feedback inhibitor 1 0.0891758
SPAG9 sperm associated antigen 9 0.0718676
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658739
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0511999
ADM adrenomedullin 0.0486611
WDR45B WD repeat domain 45B 0.0478825
BHLHE40 basic helix-loop-helix family, member e40 0.0478505
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.046984
RNMT RNA (guanine-7-) methyltransferase 0.0466564
ZNF292 zinc finger protein 292 0.0466346
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0465703
USP3 ubiquitin specific peptidase 3 0.046218
NUP58 nucleoporin 58 0.0456611
ATP13A3 ATPase type 13A3 0.0448494
PTMA prothymosin, alpha 0.0437251
GOLGA4 golgin A4 0.0435979
NAMPT nicotinamide phosphoribosyltransferase 0.042512
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0404123
NGLY1 N-glycanase 1 0.0402213
RNF24 ring finger protein 24 0.03959
UBA6 ubiquitin-like modifier activating enzyme 6 0.0393165
HELZ helicase with zinc finger 0.0386728
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.038358
KDM3A lysine (K)-specific demethylase 3A 0.0383552
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0376031
CD109 CD109 molecule 0.0371962
RNF145 ring finger protein 145 0.0357985
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0352935
MYH9 myosin, heavy chain 9, non-muscle 0.0339617
DDIT4 DNA-damage-inducible transcript 4 0.0324588
HILPDA hypoxia inducible lipid droplet-associated 0.0324166
ARRDC3 arrestin domain containing 3 0.0320832
SETD5 SET domain containing 5 0.031602
INSIG2 insulin induced gene 2 0.0315999
CHD1 chromodomain helicase DNA binding protein 1 0.0313707
OGA O-GlcNAcase 0.0313447
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0313162
FTH1 ferritin, heavy polypeptide 1 0.0310688
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0309273
RLF rearranged L-myc fusion 0.0308016
NDRG1 N-myc downstream regulated 1 0.0306972
MIMS1 mitochondrial inner membrane scaffold 1 0.0299083
WAC WW domain containing adaptor with coiled-coil 0.0289324
FNDC3B fibronectin type III domain containing 3B 0.0285494
LCORL ligand dependent nuclear receptor corepressor-like 0.0283294
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0279384
TOP2B topoisomerase (DNA) II beta 180kDa 0.0277481
UBA2 ubiquitin-like modifier activating enzyme 2 0.0271079
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0261205
TXNIP thioredoxin interacting protein 0.0258822
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0254646
HOOK2 hook microtubule-tethering protein 2 0.0253119
RNF149 ring finger protein 149 0.0251798
RBM39 RNA binding motif protein 39 0.0250547
TAC4 tachykinin 4 (hemokinin) 0.0250343
FBXO42 F-box protein 42 0.0250078
KMT2E lysine (K)-specific methyltransferase 2E 0.0250016
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0248226
NPEPPS aminopeptidase puromycin sensitive 0.0245933
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241893
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0238875
STC1 stanniocalcin 1 0.0235664
RB1CC1 RB1-inducible coiled-coil 1 0.0235375
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0235307
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0235101
NECTIN2 nectin cell adhesion molecule 2 0.0233364
RICTOR RPTOR independent companion of MTOR, complex 2 0.0230295
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0230211
SEC24A SEC24 family member A 0.0227019
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0226808
AKAP10 A kinase (PRKA) anchor protein 10 0.0226293
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0225297
IGFBP3 insulin-like growth factor binding protein 3 0.0222184
ZNF148 zinc finger protein 148 0.02184
ADAM17 ADAM metallopeptidase domain 17 0.0218293
FLNB filamin B, beta 0.0217363
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0217232
SPRED1 sprouty-related, EVH1 domain containing 1 0.0213176
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0209837
FOXO3 forkhead box O3 0.0209237
MAP2K1 mitogen-activated protein kinase kinase 1 0.0208567
ZNF654 zinc finger protein 654 0.0207204
UGCG UDP-glucose ceramide glucosyltransferase 0.0206268
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0204285
CEP192 centrosomal protein 192kDa 0.020329
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0200202
CHSY1 chondroitin sulfate synthase 1 0.0199434
PGK1 phosphoglycerate kinase 1 0.01986
CKAP5 cytoskeleton associated protein 5 0.019533
KMT2C lysine (K)-specific methyltransferase 2C 0.0195265
DOT1L DOT1-like histone H3K79 methyltransferase 0.0193539
SEC23A Sec23 homolog A (S. cerevisiae) 0.0193171
TFG TRK-fused gene 0.0192929
SRP54 signal recognition particle 54kDa 0.0192891
RAB8B RAB8B, member RAS oncogene family 0.0191603
SUCO SUN domain containing ossification factor 0.0191574
RASA3 RAS p21 protein activator 3 0.0190286

decreased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.232354
HMGA2 high mobility group AT-hook 2 -0.212647
CDH13 cadherin 13 -0.173413
COL5A1 collagen, type V, alpha 1 -0.157191
EXT1 exostosin glycosyltransferase 1 -0.151
ASPH aspartate beta-hydroxylase -0.138664
NAV1 neuron navigator 1 -0.134618
VIM vimentin -0.100547
MYO10 myosin X -0.090102
GLIS3 GLIS family zinc finger 3 -0.086506
RAI14 retinoic acid induced 14 -0.0847497
NALF1 NALCN channel auxiliary factor 1 -0.0790663
AHNAK AHNAK nucleoprotein -0.0758846
MAML3 mastermind-like 3 (Drosophila) -0.0720856
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.070156
ACTG1 actin gamma 1 -0.0687772
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0683703
COL6A3 collagen, type VI, alpha 3 -0.0678198
ZBTB20 zinc finger and BTB domain containing 20 -0.0651374
AFF3 AF4/FMR2 family, member 3 -0.0601052
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0597259
CLMP CXADR-like membrane protein -0.0595787
FMN1 formin 1 -0.0593328
TMSB10 thymosin beta 10 -0.0587597
FN1 fibronectin 1 -0.0576288
DST dystonin -0.0554729
COL6A1 collagen, type VI, alpha 1 -0.055175
VCL vinculin -0.0551228
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0547742
IGF2 insulin-like growth factor 2 -0.0541959
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0516566
ATXN1 ataxin 1 -0.0510333
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0507599
LPP LIM domain containing preferred translocation partner in lipoma -0.0497581
ARHGAP22 Rho GTPase activating protein 22 -0.0492826
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0492116
FRMD4A FERM domain containing 4A -0.0486861
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0474739
DIAPH2 diaphanous-related formin 2 -0.0473883
RPS6 ribosomal protein S6 -0.0472597
TPT1 tumor protein, translationally-controlled 1 -0.046594
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0461854
SMYD3 SET and MYND domain containing 3 -0.0460327
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0456565
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0451097
PRKCA protein kinase C, alpha -0.0447803
EFNA5 ephrin-A5 -0.0444589
CUX1 cut-like homeobox 1 -0.0440459
INTS6 integrator complex subunit 6 -0.0421486
RAD51B RAD51 paralog B -0.0419149
TAS2R14 taste receptor, type 2, member 14 -0.0415322
EGFR epidermal growth factor receptor -0.0412554
PRELID2 PRELI domain containing 2 -0.0408073
MBD5 methyl-CpG binding domain protein 5 -0.0403506
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.03983
ZBTB38 zinc finger and BTB domain containing 38 -0.0390443
PRSS23 protease, serine, 23 -0.0388003
BPTF bromodomain PHD finger transcription factor -0.0380273
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0378373
BICD1 bicaudal D homolog 1 (Drosophila) -0.0368646
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0363535
FER fer (fps/fes related) tyrosine kinase -0.0362196
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0360111
CCND1 cyclin D1 -0.0354102
ANTXR1 anthrax toxin receptor 1 -0.0350135
TPM1 tropomyosin 1 (alpha) -0.0349224
COL6A2 collagen, type VI, alpha 2 -0.0334767
AEBP2 AE binding protein 2 -0.0331507
CCDC91 coiled-coil domain containing 91 -0.0327939
RIN2 Ras and Rab interactor 2 -0.0323917
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0323648
PCBP3 poly(rC) binding protein 3 -0.0322214
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.032189
INHBA inhibin, beta A -0.0317124
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0316983
EXOC4 exocyst complex component 4 -0.031679
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0315804
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0315515
MYO9A myosin IXA -0.0315199
CDK6 cyclin-dependent kinase 6 -0.0313113
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.031272
KIAA1549L KIAA1549-like -0.0308319
NABP1 nucleic acid binding protein 1 -0.0307328
ENO1 enolase 1, (alpha) -0.0304367
FBXL7 F-box and leucine-rich repeat protein 7 -0.030279
F3 coagulation factor III (thromboplastin, tissue factor) -0.0301914
BBS9 Bardet-Biedl syndrome 9 -0.030085
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0299907
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0298695
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0297213
WWOX WW domain containing oxidoreductase -0.0293641
PRH1 proline-rich protein HaeIII subfamily 1 -0.0288938
ATG7 autophagy related 7 -0.0288164
LRMDA leucine rich melanocyte differentiation associated -0.0281012
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0280007
IGF1R insulin-like growth factor 1 receptor -0.0276849
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0272859
SAMD4A sterile alpha motif domain containing 4A -0.0271614
CDK14 cyclin-dependent kinase 14 -0.0270323
CAPN2 calpain 2, (m/II) large subunit -0.0269711