| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.11435 |
| VEGFA | vascular endothelial growth factor A | 0.062822 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0382776 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0370732 |
| ARRDC3 | arrestin domain containing 3 | 0.0346222 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0331475 |
| ADM | adrenomedullin | 0.0307383 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0305885 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0305575 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0298501 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0294977 |
| CADM1 | cell adhesion molecule 1 | 0.0267726 |
| PTMA | prothymosin, alpha | 0.0255661 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0213708 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0210154 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0204017 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0199673 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.019877 |
| XPO1 | exportin 1 | 0.019788 |
| TMSB4X | thymosin beta 4, X-linked | 0.0195873 |
| B2M | beta-2-microglobulin | 0.019202 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0186623 |
| MT2A | metallothionein 2A | 0.0179792 |
| PCBP2 | poly(rC) binding protein 2 | 0.0177923 |
| FTL | ferritin, light polypeptide | 0.017766 |
| RPS2 | ribosomal protein S2 | 0.0170903 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0152756 |
| RACK1 | receptor for activated C kinase 1 | 0.0145216 |
| RPL3 | ribosomal protein L3 | 0.0143771 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.014373 |
| YBX1 | Y box binding protein 1 | 0.0142482 |
| RPS12 | ribosomal protein S12 | 0.0142066 |
| SQLE | squalene epoxidase | 0.0134941 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0134923 |
| RPS3 | ribosomal protein S3 | 0.0132976 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0125109 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | 0.0124128 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0121905 |
| FBXO32 | F-box protein 32 | 0.0121875 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.011839 |
| RYBP | RING1 and YY1 binding protein | 0.0117313 |
| SFTPA2 | surfactant protein A2 | 0.0116336 |
| ZNF292 | zinc finger protein 292 | 0.0115982 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0114801 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0111978 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0111495 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0109242 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0108745 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0107689 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0106347 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0105769 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0101588 |
| CTSB | cathepsin B | 0.0100326 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.00994521 |
| RNF150 | ring finger protein 150 | 0.00977074 |
| FOSL1 | FOS-like antigen 1 | 0.00971884 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.00961499 |
| QKI | QKI, KH domain containing, RNA binding | 0.00926503 |
| INSIG2 | insulin induced gene 2 | 0.0092374 |
| SDF4 | stromal cell derived factor 4 | 0.00918336 |
| INSIG1 | insulin induced gene 1 | 0.00893898 |
| CCNG2 | cyclin G2 | 0.00893212 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0089277 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.00884317 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.00879433 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.00878875 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.00865557 |
| G0S2 | G0/G1 switch 2 | 0.00865281 |
| TLN1 | talin 1 | 0.00861668 |
| STC2 | stanniocalcin 2 | 0.00861207 |
| HDGF | hepatoma-derived growth factor | 0.00860191 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.00859613 |
| ATF4 | activating transcription factor 4 | 0.00853401 |
| TNS1 | tensin 1 | 0.00852886 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.00852441 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00850476 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00846868 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.00835673 |
| RIOK3 | RIO kinase 3 | 0.00824073 |
| PPP1R18 | protein phosphatase 1, regulatory subunit 18 | 0.00820715 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | 0.00816162 |
| HPS3 | Hermansky-Pudlak syndrome 3 | 0.00815066 |
| HMGB2 | high mobility group box 2 | 0.00815019 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00814352 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.00807876 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.00805548 |
| SNX3 | sorting nexin 3 | 0.00805523 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.00805321 |
| FAR1 | fatty acyl CoA reductase 1 | 0.00804537 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0079261 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.00792285 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.00790824 |
| ANKRD33B | ankyrin repeat domain 33B | 0.00786032 |
| CCNL1 | cyclin L1 | 0.00783845 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.00763542 |
| USP3 | ubiquitin specific peptidase 3 | 0.0075765 |
| RPS18 | ribosomal protein S18 | 0.00757287 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.00754505 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.00749815 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.00748512 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.344089 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202835 |
| EXT1 | exostosin glycosyltransferase 1 | -0.168074 |
| COL1A1 | collagen, type I, alpha 1 | -0.161305 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.126412 |
| CD44 | CD44 molecule (Indian blood group) | -0.0960522 |
| CDH13 | cadherin 13 | -0.0942631 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0930004 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0878481 |
| GLIS3 | GLIS family zinc finger 3 | -0.0839738 |
| ASPH | aspartate beta-hydroxylase | -0.0824663 |
| HMGA2 | high mobility group AT-hook 2 | -0.0792717 |
| FNDC3B | fibronectin type III domain containing 3B | -0.076375 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0763066 |
| COL1A2 | collagen, type I, alpha 2 | -0.0756056 |
| FBN1 | fibrillin 1 | -0.0729833 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0702639 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0645959 |
| VIM | vimentin | -0.0635497 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.059307 |
| VCL | vinculin | -0.0578564 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0572905 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0563467 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0561818 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0548007 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0541255 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0531787 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.051065 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0505637 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.050433 |
| OSMR | oncostatin M receptor | -0.0463539 |
| IL6ST | interleukin 6 signal transducer | -0.0449817 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0446434 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0445013 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0421532 |
| ACTG1 | actin gamma 1 | -0.0417258 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.040228 |
| TPM4 | tropomyosin 4 | -0.0400939 |
| CALD1 | caldesmon 1 | -0.0398677 |
| DST | dystonin | -0.03985 |
| SMYD3 | SET and MYND domain containing 3 | -0.0382195 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0382048 |
| PALLD | palladin, cytoskeletal associated protein | -0.0380349 |
| ATXN1 | ataxin 1 | -0.0378621 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0377809 |
| VCAN | versican | -0.0372589 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0369419 |
| CNTN5 | contactin 5 | -0.0368735 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0368025 |
| NAV1 | neuron navigator 1 | -0.0364374 |
| MAP1B | microtubule-associated protein 1B | -0.0361394 |
| PTK2 | protein tyrosine kinase 2 | -0.0360841 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.035955 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0357064 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0354421 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.034399 |
| TMSB10 | thymosin beta 10 | -0.0343689 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0340338 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0337044 |
| ECE1 | endothelin converting enzyme 1 | -0.0333187 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0326492 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0320597 |
| LDHA | lactate dehydrogenase A | -0.0317972 |
| NRP1 | neuropilin 1 | -0.0316942 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0314866 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.031257 |
| AHNAK | AHNAK nucleoprotein | -0.0308321 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0307742 |
| LOXL2 | lysyl oxidase-like 2 | -0.0307385 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0306033 |
| RRBP1 | ribosome binding protein 1 | -0.0302257 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0301767 |
| RIGI | RNA sensor RIG-I | -0.0299614 |
| GOLGB1 | golgin B1 | -0.0292744 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0290968 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0288857 |
| SVIL | supervillin | -0.0286653 |
| LOX | lysyl oxidase | -0.0285137 |
| CLIC4 | chloride intracellular channel 4 | -0.0284965 |
| SDC2 | syndecan 2 | -0.0284337 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0282449 |
| PDE10A | phosphodiesterase 10A | -0.0281808 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0281244 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0279801 |
| EBF1 | early B-cell factor 1 | -0.0278041 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0276437 |
| STC1 | stanniocalcin 1 | -0.0272596 |
| PRELID2 | PRELI domain containing 2 | -0.0267607 |
| HLA-B | major histocompatibility complex, class I, B | -0.026716 |
| CPQ | carboxypeptidase Q | -0.0266621 |
| FRMD4A | FERM domain containing 4A | -0.0266562 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0263652 |
| EGR1 | early growth response 1 | -0.0263443 |
| FER | fer (fps/fes related) tyrosine kinase | -0.026129 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0261251 |
| ZNF644 | zinc finger protein 644 | -0.0259332 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0258766 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0257047 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0256078 |
| MAP4 | microtubule-associated protein 4 | -0.0255368 |
