| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.237347 |
| PTMA | prothymosin, alpha | 0.0864455 |
| XPO1 | exportin 1 | 0.0690199 |
| B2M | beta-2-microglobulin | 0.0553774 |
| NDRG1 | N-myc downstream regulated 1 | 0.0493893 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0469476 |
| AHNAK | AHNAK nucleoprotein | 0.0414544 |
| RPS3 | ribosomal protein S3 | 0.0399362 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0367826 |
| RPS19 | ribosomal protein S19 | 0.0335009 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0331384 |
| MKI67 | marker of proliferation Ki-67 | 0.033123 |
| VEGFA | vascular endothelial growth factor A | 0.0326445 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0299791 |
| ARRDC3 | arrestin domain containing 3 | 0.0299418 |
| RPS12 | ribosomal protein S12 | 0.02994 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0293222 |
| CENPF | centromere protein F, 350/400kDa | 0.0290833 |
| HMGB2 | high mobility group box 2 | 0.0285458 |
| RPS8 | ribosomal protein S8 | 0.0270576 |
| PCBP2 | poly(rC) binding protein 2 | 0.0262497 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0255718 |
| RPS2 | ribosomal protein S2 | 0.0250296 |
| SET | SET nuclear proto-oncogene | 0.0243302 |
| RPL21 | ribosomal protein L21 | 0.0237331 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.023581 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.02306 |
| FRY | furry homolog (Drosophila) | 0.0221829 |
| RPL37A | ribosomal protein L37a | 0.0219126 |
| RPS17 | ribosomal protein S17 | 0.0218054 |
| TXNIP | thioredoxin interacting protein | 0.0215848 |
| FTL | ferritin, light polypeptide | 0.0214151 |
| OGA | O-GlcNAcase | 0.0202633 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0200366 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0199038 |
| ENO1 | enolase 1, (alpha) | 0.0197384 |
| ZFP36 | ZFP36 ring finger protein | 0.0192233 |
| PGK1 | phosphoglycerate kinase 1 | 0.0191589 |
| RPLP1 | ribosomal protein, large, P1 | 0.0190957 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0189556 |
| RPL18 | ribosomal protein L18 | 0.0189134 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0187893 |
| TPM3 | tropomyosin 3 | 0.01866 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0185644 |
| RPS27A | ribosomal protein S27a | 0.0185179 |
| TNS1 | tensin 1 | 0.0183358 |
| ZNF292 | zinc finger protein 292 | 0.0182658 |
| DENND4C | DENN/MADD domain containing 4C | 0.0181919 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0180389 |
| HDGF | hepatoma-derived growth factor | 0.0179983 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0179959 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0179789 |
| MMP7 | matrix metallopeptidase 7 | 0.0176795 |
| YBX1 | Y box binding protein 1 | 0.0176257 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0175785 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0174612 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0174355 |
| CXXC5 | CXXC finger protein 5 | 0.0171578 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0170986 |
| PKM | pyruvate kinase, muscle | 0.0169148 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0168724 |
| GOLGA4 | golgin A4 | 0.0166767 |
| APOL1 | apolipoprotein L, 1 | 0.0164755 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0163938 |
| HSPA4L | heat shock 70kDa protein 4-like | 0.0161254 |
| CCNG2 | cyclin G2 | 0.0161215 |
| ERBIN | erbb2 interacting protein | 0.0159625 |
| TMSB4X | thymosin beta 4, X-linked | 0.0157565 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0153726 |
| HOXB3 | homeobox B3 | 0.0150841 |
| SFTPA2 | surfactant protein A2 | 0.0149613 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0147296 |
| TPI1 | triosephosphate isomerase 1 | 0.0145868 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0145242 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0144153 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.014388 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0143604 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0142081 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0141791 |
| FAM13A | family with sequence similarity 13, member A | 0.0139982 |
| CEBPG | CCAAT/enhancer binding protein (C/EBP), gamma | 0.0139479 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0138956 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0138818 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0137284 |
| ANLN | anillin, actin binding protein | 0.013693 |
| KRT19 | keratin 19, type I | 0.0136292 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0136021 |
| ITGA1 | integrin, alpha 1 | 0.0135994 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0135368 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0134097 |
| RPL3 | ribosomal protein L3 | 0.0132536 |
| S100A6 | S100 calcium binding protein A6 | 0.0132279 |
| LCN2 | lipocalin 2 | 0.0130595 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0129662 |
| RPL23 | ribosomal protein L23 | 0.0128694 |
| PDE8A | phosphodiesterase 8A | 0.0128476 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0128325 |
| CDK19 | cyclin-dependent kinase 19 | 0.0128012 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0126832 |
| REPS1 | RALBP1 associated Eps domain containing 1 | 0.0126479 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | -0.144328 |
| LMO7 | LIM domain 7 | -0.119174 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.103441 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.101639 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0957386 |
| SMAD3 | SMAD family member 3 | -0.0931018 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0886279 |
| TJP1 | tight junction protein 1 | -0.0873028 |
| MYO1E | myosin IE | -0.082183 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0708408 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0669505 |
| VCL | vinculin | -0.0618162 |
| ATXN1 | ataxin 1 | -0.0611553 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0556298 |
| WWC1 | WW and C2 domain containing 1 | -0.0528028 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0515935 |
| ACTN4 | actinin, alpha 4 | -0.0494259 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0492958 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0481112 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0474409 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0467809 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0461304 |
| FLNB | filamin B, beta | -0.0452829 |
| CTBP2 | C-terminal binding protein 2 | -0.0449171 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0446594 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0446312 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0442315 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.044207 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0440977 |
| SEPTIN9 | septin 9 | -0.0436937 |
| TXNRD1 | thioredoxin reductase 1 | -0.0431606 |
| LAMA4 | laminin, alpha 4 | -0.0430322 |
| BCL2L1 | BCL2-like 1 | -0.0421927 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0420175 |
| TRIB1 | tribbles pseudokinase 1 | -0.041792 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.041592 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.041342 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0405407 |
| NF1 | neurofibromin 1 | -0.0401942 |
| HM13 | histocompatibility (minor) 13 | -0.0393755 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0390305 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0387468 |
| KRT20 | keratin 20, type I | -0.0383762 |
| GOLGB1 | golgin B1 | -0.0381008 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0380239 |
| EGR1 | early growth response 1 | -0.0378598 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0373961 |
| ANXA2 | annexin A2 | -0.0366079 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0363331 |
| RTN3 | reticulon 3 | -0.0355931 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0349639 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0348871 |
| HDLBP | high density lipoprotein binding protein | -0.0343368 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0343104 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0338984 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0338749 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0336274 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0335773 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0328269 |
| CD2AP | CD2-associated protein | -0.0324983 |
| POF1B | premature ovarian failure, 1B | -0.0322268 |
| FOXO1 | forkhead box O1 | -0.0321915 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.031576 |
| KRT8 | keratin 8, type II | -0.031442 |
| EXPH5 | exophilin 5 | -0.0313708 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0312277 |
| SETX | senataxin | -0.0308383 |
| AGR2 | anterior gradient 2 | -0.0307626 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0300748 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0299766 |
| NUP98 | nucleoporin 98kDa | -0.0298522 |
| DST | dystonin | -0.0295693 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0295474 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0294056 |
| EZR | ezrin | -0.0292825 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0290816 |
| TMEM65 | transmembrane protein 65 | -0.0290742 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0286308 |
| SGMS2 | sphingomyelin synthase 2 | -0.0285202 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0284397 |
| UTRN | utrophin | -0.0283782 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0282356 |
| INTS6 | integrator complex subunit 6 | -0.0280762 |
| JMJD1C | jumonji domain containing 1C | -0.0279813 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0278847 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0278543 |
| RAB1A | RAB1A, member RAS oncogene family | -0.027821 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0277616 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0275252 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.027458 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0271786 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.02712 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0270652 |
| STK24 | serine/threonine kinase 24 | -0.0269583 |
| NTN4 | netrin 4 | -0.0269211 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0266052 |
| TES | testin LIM domain protein | -0.0264909 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0262515 |
| RBM39 | RNA binding motif protein 39 | -0.0259984 |
| COG5 | component of oligomeric golgi complex 5 | -0.025979 |
