| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.372457 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.306643 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.188308 |
| C3 | complement component 3 | 0.132205 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0969034 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0573784 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0555435 |
| APOB | apolipoprotein B | 0.0541441 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0525708 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0522835 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0501944 |
| VEGFA | vascular endothelial growth factor A | 0.0487449 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0485147 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0484715 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0480729 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.042698 |
| CRLS1 | cardiolipin synthase 1 | 0.0412122 |
| HLF | hepatic leukemia factor | 0.0397579 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0392758 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.03718 |
| VCL | vinculin | 0.036878 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0365225 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0364703 |
| TOP1 | topoisomerase (DNA) I | 0.0346604 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0343521 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0342821 |
| JAG1 | jagged 1 | 0.0335872 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0318967 |
| SVIL | supervillin | 0.0307541 |
| MALT1 | MALT1 paracaspase | 0.0305869 |
| ANXA5 | annexin A5 | 0.0301178 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0291463 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0291207 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0289426 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0288651 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0287682 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0285017 |
| CPE | carboxypeptidase E | 0.0283963 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0281584 |
| MRTFA | myocardin related transcription factor A | 0.0279306 |
| RPL11 | ribosomal protein L11 | 0.0278151 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0277355 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0274697 |
| RTN4 | reticulon 4 | 0.027305 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0267978 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0260494 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0260079 |
| LCN2 | lipocalin 2 | 0.0258466 |
| TNS1 | tensin 1 | 0.0255109 |
| PCBP2 | poly(rC) binding protein 2 | 0.0254763 |
| DSPP | dentin sialophosphoprotein | 0.0254521 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0250351 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.025015 |
| MATR3 | matrin 3 | 0.0248089 |
| TXNIP | thioredoxin interacting protein | 0.0245042 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0244665 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0243716 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.024286 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0242 |
| NPTN | neuroplastin | 0.0241462 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0240039 |
| PRELID2 | PRELI domain containing 2 | 0.0238516 |
| GOLGA4 | golgin A4 | 0.0237994 |
| SMAD3 | SMAD family member 3 | 0.0236995 |
| FRK | fyn-related Src family tyrosine kinase | 0.0236318 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0234194 |
| FERMT2 | fermitin family member 2 | 0.023366 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0233254 |
| CFB | complement factor B | 0.0232884 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0232426 |
| GDF15 | growth differentiation factor 15 | 0.0228146 |
| RPL3 | ribosomal protein L3 | 0.0227072 |
| TRIM24 | tripartite motif containing 24 | 0.0226872 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.022398 |
| ANO6 | anoctamin 6 | 0.0223107 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0220649 |
| CHKA | choline kinase alpha | 0.0219721 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0219692 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0218903 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0218758 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0214509 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0214291 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0212574 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0211714 |
| DENND5A | DENN/MADD domain containing 5A | 0.0210947 |
| SMAD4 | SMAD family member 4 | 0.0210658 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0209059 |
| SIK3 | SIK family kinase 3 | 0.0208415 |
| DIAPH1 | diaphanous-related formin 1 | 0.0207282 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0206952 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0206491 |
| MT2A | metallothionein 2A | 0.0205864 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0204102 |
| CUL3 | cullin 3 | 0.0200056 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0199578 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0199117 |
| MCL1 | myeloid cell leukemia 1 | 0.0199007 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | 0.0197041 |
| MED13L | mediator complex subunit 13-like | 0.0196601 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0196429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.192126 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.148017 |
| EHBP1 | EH domain binding protein 1 | -0.136762 |
| CP | ceruloplasmin (ferroxidase) | -0.0994142 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0932135 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0787797 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0786982 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0750754 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0735435 |
| GPC6 | glypican 6 | -0.0721672 |
| AHSG | alpha-2-HS-glycoprotein | -0.0719707 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0706994 |
| PARD3 | par-3 family cell polarity regulator | -0.0645785 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0636379 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0605327 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0592411 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0592152 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0587435 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0582419 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.055953 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0549298 |
| TMEM123 | transmembrane protein 123 | -0.0517463 |
| TRIM26 | tripartite motif containing 26 | -0.0471751 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0464554 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.046392 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0463215 |
| NHSL1 | NHS-like 1 | -0.0459514 |
| FRMD5 | FERM domain containing 5 | -0.0454744 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0436116 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0433749 |
| RPS6 | ribosomal protein S6 | -0.0430076 |
| GPC3 | glypican 3 | -0.0428061 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0423269 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0422069 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0415698 |
| CNKSR3 | CNKSR family member 3 | -0.0413364 |
| RPS24 | ribosomal protein S24 | -0.0401273 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0396518 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0387284 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0383267 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0381046 |
| UTRN | utrophin | -0.0377514 |
| GNAS | GNAS complex locus | -0.037415 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0368084 |
| ZFHX3 | zinc finger homeobox 3 | -0.0364615 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0364061 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0363361 |
| IER3 | immediate early response 3 | -0.0361826 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0361031 |
| DST | dystonin | -0.0360256 |
| MAP4 | microtubule-associated protein 4 | -0.0346636 |
| APOA2 | apolipoprotein A-II | -0.0345286 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342769 |
| RBM39 | RNA binding motif protein 39 | -0.0342273 |
| APOE | apolipoprotein E | -0.0338694 |
| RRBP1 | ribosome binding protein 1 | -0.0332439 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0332361 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0330785 |
| SYN3 | synapsin III | -0.0323917 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0323481 |
| NPR2 | natriuretic peptide receptor 2 | -0.0313474 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0306041 |
| DOK6 | docking protein 6 | -0.0302048 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0294002 |
| CDK6 | cyclin-dependent kinase 6 | -0.0290811 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0288661 |
| ATP10A | ATPase, class V, type 10A | -0.0285989 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0281246 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0281218 |
| MAP1B | microtubule-associated protein 1B | -0.0280394 |
| TCF12 | transcription factor 12 | -0.0271842 |
| TPM4 | tropomyosin 4 | -0.0271387 |
| STK17A | serine/threonine kinase 17a | -0.0269414 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.02684 |
| RPS8 | ribosomal protein S8 | -0.0266206 |
| HMGA2 | high mobility group AT-hook 2 | -0.0265865 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0265757 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0261003 |
| MATN3 | matrilin 3 | -0.0259991 |
| A2M | alpha-2-macroglobulin | -0.0257798 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0257151 |
| FMNL2 | formin-like 2 | -0.0250709 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0248934 |
| HDLBP | high density lipoprotein binding protein | -0.0247784 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0245252 |
| PTCHD4 | patched domain containing 4 | -0.0244534 |
| PEG10 | paternally expressed 10 | -0.0244287 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0242271 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0239161 |
| CCNY | cyclin Y | -0.0233766 |
| ARF1 | ADP-ribosylation factor 1 | -0.0230248 |
| FTL | ferritin, light polypeptide | -0.0228829 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0227285 |
| TBC1D4 | TBC1 domain family, member 4 | -0.0227132 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.022654 |
| SELENOP | selenoprotein P | -0.0225434 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0224595 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0223001 |
| RPL34 | ribosomal protein L34 | -0.0222977 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.022237 |
