Osimertinib (mesylate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.236213
B2M beta-2-microglobulin 0.145167
FTH1 ferritin, heavy polypeptide 1 0.142894
PTMA prothymosin, alpha 0.107585
MT2A metallothionein 2A 0.0896883
CLU clusterin 0.0849816
MSN moesin 0.0803068
TMSB4X thymosin beta 4, X-linked 0.0735591
MYH9 myosin, heavy chain 9, non-muscle 0.0703769
RPS6 ribosomal protein S6 0.0611573
KRT17 keratin 17, type I 0.0584518
RPS3 ribosomal protein S3 0.055023
ENO1 enolase 1, (alpha) 0.0547331
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0544068
RPS19 ribosomal protein S19 0.053695
PCDH1 protocadherin 1 0.0509511
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0505948
IFITM3 interferon induced transmembrane protein 3 0.0505371
SRRM2 serine/arginine repetitive matrix 2 0.0499246
IFITM1 interferon induced transmembrane protein 1 0.0484206
FTL ferritin, light polypeptide 0.0479373
TXNIP thioredoxin interacting protein 0.0475066
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0471712
RPS12 ribosomal protein S12 0.0463919
POTEF POTE ankyrin domain family, member F 0.045972
RPLP2 ribosomal protein, large, P2 0.0452538
EEF2 eukaryotic translation elongation factor 2 0.0446829
RPL11 ribosomal protein L11 0.0444748
PLS3 plastin 3 0.0431736
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0423261
RPS8 ribosomal protein S8 0.0420539
LMO7 LIM domain 7 0.0419417
TMSB10 thymosin beta 10 0.0417298
SFTPA2 surfactant protein A2 0.0416896
ARRDC3 arrestin domain containing 3 0.0409774
YBX1 Y box binding protein 1 0.04065
RPL12 ribosomal protein L12 0.0406364
PRRC2C proline-rich coiled-coil 2C 0.0406356
PGK1 phosphoglycerate kinase 1 0.0400631
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0392724
RPS13 ribosomal protein S13 0.0390584
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0389408
ALCAM activated leukocyte cell adhesion molecule 0.0383377
PCBP2 poly(rC) binding protein 2 0.0369744
HDGF hepatoma-derived growth factor 0.0358438
IFI6 interferon, alpha-inducible protein 6 0.0356776
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0353283
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0348276
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0347915
KTN1 kinectin 1 (kinesin receptor) 0.0337854
ZFP36L1 ZFP36 ring finger protein-like 1 0.0329816
TPM3 tropomyosin 3 0.0327473
S100A11 S100 calcium binding protein A11 0.0314531
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0314484
DHFR dihydrofolate reductase 0.0313585
RPL37 ribosomal protein L37 0.0312335
RPS2 ribosomal protein S2 0.03122
ENO2 enolase 2 (gamma, neuronal) 0.0311994
HLA-A major histocompatibility complex, class I, A 0.03072
EIF1 eukaryotic translation initiation factor 1 0.0304067
SLK STE20-like kinase 0.0301897
LDHA lactate dehydrogenase A 0.030015
ADM adrenomedullin 0.0297213
RPL21 ribosomal protein L21 0.0296323
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0294427
RCOR1 REST corepressor 1 0.0291826
CD9 CD9 molecule 0.0291473
CSTB cystatin B (stefin B) 0.0288429
TGM2 transglutaminase 2 0.0286933
CALB1 calbindin 1, 28kDa 0.0283312
IFI44L interferon-induced protein 44-like 0.0282407
RPS14 ribosomal protein S14 0.0281801
TPI1 triosephosphate isomerase 1 0.0281016
SET SET nuclear proto-oncogene 0.02772
XPO1 exportin 1 0.0271108
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0267648
IFI27 interferon, alpha-inducible protein 27 0.0264977
VEGFA vascular endothelial growth factor A 0.0259637
RPLP1 ribosomal protein, large, P1 0.0257238
RPL37A ribosomal protein L37a 0.0257086
RPL3 ribosomal protein L3 0.025552
RACK1 receptor for activated C kinase 1 0.0255506
GOLGA4 golgin A4 0.0253128
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0251995
CNRIP1 cannabinoid receptor interacting protein 1 0.0250208
RPL36 ribosomal protein L36 0.0248619
LUZP1 leucine zipper protein 1 0.0247533
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0246438
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.0245158
S100A9 S100 calcium binding protein A9 0.0244857
BHLHE40 basic helix-loop-helix family, member e40 0.0242745
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0241109
RPL31 ribosomal protein L31 0.0240229
CAV2 caveolin 2 0.0238709
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0238582
PICALM phosphatidylinositol binding clathrin assembly protein 0.0238537
APLP2 amyloid beta (A4) precursor-like protein 2 0.0236429
MKI67 marker of proliferation Ki-67 0.023541
CTSB cathepsin B 0.023473
MT1X metallothionein 1X 0.0231979

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.144801
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.130235
TRIO trio Rho guanine nucleotide exchange factor -0.0826691
PRELID2 PRELI domain containing 2 -0.0824861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0788024
RIN2 Ras and Rab interactor 2 -0.0764849
KIAA1217 KIAA1217 -0.0742511
FOXO1 forkhead box O1 -0.0692397
OSMR oncostatin M receptor -0.06706
DPYD dihydropyrimidine dehydrogenase -0.0630243
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0623618
CEMIP cell migration inducing protein, hyaluronan binding -0.0617066
MTSS1 metastasis suppressor 1 -0.0608029
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0591758
NRG1 neuregulin 1 -0.0585291
FLNB filamin B, beta -0.0579485
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0530195
NEK7 NIMA-related kinase 7 -0.0518898
FOXP1 forkhead box P1 -0.0516865
AOPEP aminopeptidase O (putative) -0.0508955
SMAD3 SMAD family member 3 -0.0488339
ASPH aspartate beta-hydroxylase -0.0462529
NDRG1 N-myc downstream regulated 1 -0.0450114
SEC31A SEC31 homolog A (S. cerevisiae) -0.0439889
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0432357
NAMPT nicotinamide phosphoribosyltransferase -0.0426961
MYOF myoferlin -0.0422845
ANKRD10 ankyrin repeat domain 10 -0.0421105
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0416106
BMAL2 basic helix-loop-helix ARNT like 2 -0.040483
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0400458
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0383326
RICTOR RPTOR independent companion of MTOR, complex 2 -0.037912
EMP1 epithelial membrane protein 1 -0.0372903
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0369457
NRCAM neuronal cell adhesion molecule -0.0362836
DOCK5 dedicator of cytokinesis 5 -0.0354616
NT5C2 5'-nucleotidase, cytosolic II -0.0348136
RBM39 RNA binding motif protein 39 -0.0344668
NDE1 nudE neurodevelopment protein 1 -0.0342193
AHNAK AHNAK nucleoprotein -0.0341539
ITCH itchy E3 ubiquitin protein ligase -0.0341352
NRIP1 nuclear receptor interacting protein 1 -0.0334986
COG5 component of oligomeric golgi complex 5 -0.0332512
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0332146
GRB10 growth factor receptor-bound protein 10 -0.0331834
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0328247
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0326467
MARCHF6 membrane associated ring-CH-type finger 6 -0.0323785
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0319731
DLG1 discs, large homolog 1 (Drosophila) -0.0316674
ARHGAP29 Rho GTPase activating protein 29 -0.0311975
EXOC6B exocyst complex component 6B -0.0307789
HSPG2 heparan sulfate proteoglycan 2 -0.0304825
HM13 histocompatibility (minor) 13 -0.0299725
SMYD3 SET and MYND domain containing 3 -0.0298694
CAV1 caveolin 1, caveolae protein, 22kDa -0.0290086
PTK2 protein tyrosine kinase 2 -0.0283744
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0282972
OSBPL3 oxysterol binding protein-like 3 -0.0282408
OGA O-GlcNAcase -0.0282012
ARF1 ADP-ribosylation factor 1 -0.0280538
MBNL2 muscleblind-like splicing regulator 2 -0.0275695
MBD5 methyl-CpG binding domain protein 5 -0.0273986
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0273905
LOC112694756 uncharaterized LOC112694756 -0.0273201
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0270293
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269426
SBF2 SET binding factor 2 -0.0269423
GNAS GNAS complex locus -0.0269167
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0264888
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.026386
NIBAN2 niban apoptosis regulator 2 -0.0261908
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -0.0259452
DOCK9 dedicator of cytokinesis 9 -0.0256585
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0255992
RPS24 ribosomal protein S24 -0.0252301
NBAS neuroblastoma amplified sequence -0.0249991
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0248733
ZNF217 zinc finger protein 217 -0.0247125
SEC24D SEC24 family member D -0.0242985
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0242419
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0241908
ZNFX1 zinc finger, NFX1-type containing 1 -0.02367
TMEM263 transmembrane protein 263 -0.0235738
LOXL2 lysyl oxidase-like 2 -0.0235201
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0234721
CD44 CD44 molecule (Indian blood group) -0.0233755
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0231351
IER3 immediate early response 3 -0.0230623
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0229416
NFIA nuclear factor I/A -0.0227142
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0225759
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.022439
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0223943
PDE4D phosphodiesterase 4D, cAMP-specific -0.0223183
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0222143
BZW1 basic leucine zipper and W2 domains 1 -0.0221892
SDCBP syndecan binding protein (syntenin) -0.0219984
EFNA5 ephrin-A5 -0.021951