| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.150281 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.117217 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.101235 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0882996 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0676578 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0621602 |
| ATP13A3 | ATPase type 13A3 | 0.0563029 |
| ZNF841 | zinc finger protein 841 | 0.0508018 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0420176 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.041768 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0388056 |
| CANX | calnexin | 0.0385784 |
| ADM | adrenomedullin | 0.0379118 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0376407 |
| NUP58 | nucleoporin 58 | 0.0375152 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0340145 |
| GOLGA4 | golgin A4 | 0.0337462 |
| CALR | calreticulin | 0.0331059 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0326531 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0302982 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0279612 |
| SMAD3 | SMAD family member 3 | 0.0279206 |
| SPAG9 | sperm associated antigen 9 | 0.0276832 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0275045 |
| PCBP2 | poly(rC) binding protein 2 | 0.0261799 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.02601 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0255365 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0244774 |
| TMF1 | TATA element modulatory factor 1 | 0.0237213 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0234687 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0226294 |
| FLNB | filamin B, beta | 0.022253 |
| SUCO | SUN domain containing ossification factor | 0.0218696 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0218316 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0211167 |
| TLN1 | talin 1 | 0.020912 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0205459 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0201144 |
| AFAP1 | actin filament associated protein 1 | 0.0196768 |
| ARRDC3 | arrestin domain containing 3 | 0.0196306 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0192546 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0191363 |
| JUN | jun proto-oncogene | 0.0188856 |
| PLK2 | polo-like kinase 2 | 0.0188232 |
| ANO6 | anoctamin 6 | 0.018633 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0185336 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0182207 |
| SET | SET nuclear proto-oncogene | 0.0181883 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0177948 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0175581 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0175254 |
| B2M | beta-2-microglobulin | 0.0174692 |
| ARF4 | ADP-ribosylation factor 4 | 0.017453 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0172164 |
| GOLGA2 | golgin A2 | 0.016945 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0168475 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.016806 |
| TPR | translocated promoter region, nuclear basket protein | 0.01673 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0166484 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0165985 |
| MKI67 | marker of proliferation Ki-67 | 0.0165927 |
| FLNA | filamin A, alpha | 0.0165806 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0165533 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0164474 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0163651 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0161773 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0159159 |
| SFTPA2 | surfactant protein A2 | 0.0158791 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0158048 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0157574 |
| COL5A1 | collagen, type V, alpha 1 | 0.0154251 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0153844 |
| TPM3 | tropomyosin 3 | 0.0153041 |
| ANXA1 | annexin A1 | 0.0152675 |
| SSR1 | signal sequence receptor, alpha | 0.0152532 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0151641 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0150981 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0150555 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0149491 |
| HMGB2 | high mobility group box 2 | 0.0149359 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0147825 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0147516 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0146611 |
| HELZ | helicase with zinc finger | 0.0145325 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0143659 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0143346 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0143131 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0140521 |
| RBM39 | RNA binding motif protein 39 | 0.0139704 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0139587 |
| KIF5B | kinesin family member 5B | 0.0138828 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0138764 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0138055 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0136353 |
| CCNL1 | cyclin L1 | 0.0134797 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0134102 |
| CDC73 | cell division cycle 73 | 0.0132871 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0132058 |
| RLF | rearranged L-myc fusion | 0.0131919 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0131283 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.168928 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.129335 |
| FN1 | fibronectin 1 | -0.125561 |
| HLA-B | major histocompatibility complex, class I, B | -0.125338 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.092034 |
| FTL | ferritin, light polypeptide | -0.069685 |
| MT2A | metallothionein 2A | -0.0663935 |
| ACTG1 | actin gamma 1 | -0.0627252 |
| POTEF | POTE ankyrin domain family, member F | -0.0573199 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0535857 |
| NDRG1 | N-myc downstream regulated 1 | -0.0528789 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0493802 |
| VIM | vimentin | -0.048745 |
| EXT1 | exostosin glycosyltransferase 1 | -0.045133 |
| DEK | DEK proto-oncogene | -0.0419015 |
| TMSB10 | thymosin beta 10 | -0.0384467 |
| GLIS3 | GLIS family zinc finger 3 | -0.0379883 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0375601 |
| RPS6 | ribosomal protein S6 | -0.0359723 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0358966 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0344159 |
| ASPH | aspartate beta-hydroxylase | -0.0342466 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0342322 |
| HLA-A | major histocompatibility complex, class I, A | -0.0335773 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0335094 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0324064 |
| CTSD | cathepsin D | -0.0322427 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0305615 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0302074 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0299946 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0298026 |
| ERBIN | erbb2 interacting protein | -0.0287207 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0287197 |
| FHIT | fragile histidine triad | -0.0277668 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0275583 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.027291 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0268519 |
| PKM | pyruvate kinase, muscle | -0.0267896 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0264692 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0255573 |
| TUBA1B | tubulin, alpha 1b | -0.0251699 |
| DIAPH3 | diaphanous-related formin 3 | -0.0251544 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0251047 |
| ZNF804A | zinc finger protein 804A | -0.0246295 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0242455 |
| MT1X | metallothionein 1X | -0.0240657 |
| PFN1 | profilin 1 | -0.0239468 |
| TUBB | tubulin, beta class I | -0.0235922 |
| FOXP1 | forkhead box P1 | -0.023414 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0228807 |
| RAD51B | RAD51 paralog B | -0.0227682 |
| TENM3 | teneurin transmembrane protein 3 | -0.022492 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.022422 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0214981 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0212824 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0209121 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0203668 |
| S100A10 | S100 calcium binding protein A10 | -0.0203412 |
| HMGB1 | high mobility group box 1 | -0.0202426 |
| RPL35A | ribosomal protein L35a | -0.02023 |
| MAP4 | microtubule-associated protein 4 | -0.0199481 |
| MAP1B | microtubule-associated protein 1B | -0.0198461 |
| CUX1 | cut-like homeobox 1 | -0.0197025 |
| RASAL2 | RAS protein activator like 2 | -0.0196282 |
| CAVIN1 | caveolae associated protein 1 | -0.0195628 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0193634 |
| GNAS | GNAS complex locus | -0.01908 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0187936 |
| EXOC4 | exocyst complex component 4 | -0.018476 |
| SMYD3 | SET and MYND domain containing 3 | -0.0183469 |
| WNT5B | wingless-type MMTV integration site family, member 5B | -0.0183202 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.018156 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0180882 |
| KRT7 | keratin 7, type II | -0.0180857 |
| MMP12 | matrix metallopeptidase 12 | -0.0178829 |
| PLSCR1 | phospholipid scramblase 1 | -0.0178339 |
| BPTF | bromodomain PHD finger transcription factor | -0.0178191 |
| OSMR | oncostatin M receptor | -0.0177501 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.017647 |
| CCND1 | cyclin D1 | -0.0175867 |
| RPS24 | ribosomal protein S24 | -0.0175837 |
| INTS6 | integrator complex subunit 6 | -0.017435 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.017433 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0174276 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0173799 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0172542 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0172246 |
| TPM4 | tropomyosin 4 | -0.0169321 |
| KLF12 | Kruppel-like factor 12 | -0.0167634 |
| RPLP1 | ribosomal protein, large, P1 | -0.0163436 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0162751 |
| RPS13 | ribosomal protein S13 | -0.0162145 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0162033 |
| CCDC80 | coiled-coil domain containing 80 | -0.0161906 |
| HDAC9 | histone deacetylase 9 | -0.0161159 |
| HMGA1 | high mobility group AT-hook 1 | -0.0160424 |
| S100A6 | S100 calcium binding protein A6 | -0.0160064 |
| CDK6 | cyclin-dependent kinase 6 | -0.0160005 |
| RPL27A | ribosomal protein L27a | -0.0159293 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0159081 |
