| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.226977 |
| VIM | vimentin | 0.0924504 |
| TMSB10 | thymosin beta 10 | 0.075831 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0731654 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0730466 |
| PTMA | prothymosin, alpha | 0.0711302 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0652278 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0514052 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0443056 |
| CTSB | cathepsin B | 0.0411007 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.040079 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0400137 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0390945 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0381918 |
| NUP58 | nucleoporin 58 | 0.0376323 |
| ADM | adrenomedullin | 0.0359514 |
| RPS3 | ribosomal protein S3 | 0.0346783 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0339628 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0334939 |
| ATP13A3 | ATPase type 13A3 | 0.0321833 |
| RNF145 | ring finger protein 145 | 0.0319176 |
| RPL35A | ribosomal protein L35a | 0.0315803 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0306392 |
| SPAG9 | sperm associated antigen 9 | 0.0304585 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0300227 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0296252 |
| JUN | jun proto-oncogene | 0.0296091 |
| MT2A | metallothionein 2A | 0.0295769 |
| ANXA2 | annexin A2 | 0.029014 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0286606 |
| WDR43 | WD repeat domain 43 | 0.0285635 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0278521 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0276214 |
| H1-0 | H1.0 linker histone | 0.0273996 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0269091 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0267728 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0265038 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0246758 |
| CD109 | CD109 molecule | 0.0235433 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0233159 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0231383 |
| RACK1 | receptor for activated C kinase 1 | 0.0222284 |
| PCBP2 | poly(rC) binding protein 2 | 0.0221034 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0220537 |
| RPS19 | ribosomal protein S19 | 0.0211121 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0209931 |
| RPL12 | ribosomal protein L12 | 0.0206217 |
| RPS27A | ribosomal protein S27a | 0.0196986 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0196334 |
| QKI | QKI, KH domain containing, RNA binding | 0.0194374 |
| TPI1 | triosephosphate isomerase 1 | 0.0192819 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0191233 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0190172 |
| RPS12 | ribosomal protein S12 | 0.0189795 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0187402 |
| YBX1 | Y box binding protein 1 | 0.0183032 |
| RPL37A | ribosomal protein L37a | 0.0182907 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0182434 |
| RPS7 | ribosomal protein S7 | 0.0177827 |
| PGK1 | phosphoglycerate kinase 1 | 0.0173339 |
| ATF4 | activating transcription factor 4 | 0.0172303 |
| FLNA | filamin A, alpha | 0.0165371 |
| WDR45B | WD repeat domain 45B | 0.0163616 |
| PLIN2 | perilipin 2 | 0.0162387 |
| CLIC1 | chloride intracellular channel 1 | 0.016134 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0161291 |
| SFTPA2 | surfactant protein A2 | 0.0160498 |
| HDAC3 | histone deacetylase 3 | 0.0160037 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0159573 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0158897 |
| RAI1 | retinoic acid induced 1 | 0.0158359 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0157955 |
| RPL36 | ribosomal protein L36 | 0.0156586 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0152637 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0151864 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0145704 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0144761 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0142946 |
| RAB8B | RAB8B, member RAS oncogene family | 0.013917 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0136682 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0135667 |
| RPL11 | ribosomal protein L11 | 0.0134112 |
| ZNF292 | zinc finger protein 292 | 0.013267 |
| CCSAP | centriole, cilia and spindle-associated protein | 0.0131677 |
| RPL23 | ribosomal protein L23 | 0.0130536 |
| RPS14 | ribosomal protein S14 | 0.0130429 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0129814 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0127269 |
| MALT1 | MALT1 paracaspase | 0.0127153 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0125644 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0124707 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.0123658 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.012323 |
| TRIM33 | tripartite motif containing 33 | 0.0122435 |
| CSTB | cystatin B (stefin B) | 0.0122299 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0119224 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0118723 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0118052 |
| USP3 | ubiquitin specific peptidase 3 | 0.0116505 |
| ARRDC3 | arrestin domain containing 3 | 0.011646 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.505975 |
| EXT1 | exostosin glycosyltransferase 1 | -0.100403 |
| ASPH | aspartate beta-hydroxylase | -0.100161 |
| ACTG1 | actin gamma 1 | -0.0949473 |
| EFNA5 | ephrin-A5 | -0.0794159 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0730821 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0618307 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0572403 |
| USP34 | ubiquitin specific peptidase 34 | -0.0568917 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0528236 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0498933 |
| GPC6 | glypican 6 | -0.0491891 |
| RPS6 | ribosomal protein S6 | -0.048343 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0468144 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0466753 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0445113 |
| CALD1 | caldesmon 1 | -0.0406085 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0404813 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0388724 |
| KIAA1217 | KIAA1217 | -0.038767 |
| RUNX1 | runt-related transcription factor 1 | -0.0383618 |
| CDK6 | cyclin-dependent kinase 6 | -0.0381074 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0375867 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0360644 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0355903 |
| PKM | pyruvate kinase, muscle | -0.0354411 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0349795 |
| NDRG1 | N-myc downstream regulated 1 | -0.0347633 |
| TXNRD1 | thioredoxin reductase 1 | -0.0336057 |
| NAV1 | neuron navigator 1 | -0.0324855 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0323698 |
| PTK2 | protein tyrosine kinase 2 | -0.0323509 |
| CDH13 | cadherin 13 | -0.0319739 |
| JMJD1C | jumonji domain containing 1C | -0.0316681 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0315986 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0313048 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0311769 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0310711 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0310135 |
| MSR1 | macrophage scavenger receptor 1 | -0.0309651 |
| KIAA1549L | KIAA1549-like | -0.0308194 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0305817 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0304929 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0304196 |
| GPHN | gephyrin | -0.0302345 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.030117 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0297344 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.029515 |
| SMYD3 | SET and MYND domain containing 3 | -0.0294745 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0290221 |
| HMGA2 | high mobility group AT-hook 2 | -0.0288789 |
| HDAC9 | histone deacetylase 9 | -0.0288522 |
| ANO6 | anoctamin 6 | -0.0284859 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0283712 |
| HMGA1 | high mobility group AT-hook 1 | -0.0283236 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0283226 |
| BPTF | bromodomain PHD finger transcription factor | -0.0281461 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0277094 |
| POTEF | POTE ankyrin domain family, member F | -0.0276254 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0270531 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0268579 |
| DTNA | dystrobrevin, alpha | -0.0264862 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0264403 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0263847 |
| NABP1 | nucleic acid binding protein 1 | -0.0262653 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0261067 |
| NF1 | neurofibromin 1 | -0.0259351 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0259214 |
| ZNF804A | zinc finger protein 804A | -0.0258052 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0256588 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0253348 |
| RTN4 | reticulon 4 | -0.0252647 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0251004 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0250962 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0249682 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0246362 |
| EXOC6B | exocyst complex component 6B | -0.0244598 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0242619 |
| RPS23 | ribosomal protein S23 | -0.0238343 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0237921 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0237738 |
| TAOK1 | TAO kinase 1 | -0.0236942 |
| CDK14 | cyclin-dependent kinase 14 | -0.0236622 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0235604 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0235471 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0233216 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0232356 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0228987 |
| ATXN1 | ataxin 1 | -0.0227549 |
| TLE4 | transducin-like enhancer of split 4 | -0.0227183 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0226974 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0225346 |
| VCL | vinculin | -0.0223477 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.021779 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.021622 |
| NBAS | neuroblastoma amplified sequence | -0.021523 |
| PCNX4 | pecanex 4 | -0.0215004 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0213909 |
| SBF2 | SET binding factor 2 | -0.0211954 |
| NTM | neurotrimin | -0.0211083 |
