Osimertinib (mesylate)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Osimertinib (mesylate) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Osimertinib (mesylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.304774
PTMA prothymosin, alpha 0.213788
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.072391
TMSB10 thymosin beta 10 0.0720485
RPL35A ribosomal protein L35a 0.0674046
EEF2 eukaryotic translation elongation factor 2 0.058311
S100P S100 calcium binding protein P 0.0533165
RPS3 ribosomal protein S3 0.0519832
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0465143
RPL23 ribosomal protein L23 0.0462095
RPL12 ribosomal protein L12 0.0457965
RPLP1 ribosomal protein, large, P1 0.0435177
RPL26 ribosomal protein L26 0.0423712
RPS19 ribosomal protein S19 0.0405405
RACK1 receptor for activated C kinase 1 0.0396191
DDIT4 DNA-damage-inducible transcript 4 0.0359402
TMSB4X thymosin beta 4, X-linked 0.0353663
RPL36 ribosomal protein L36 0.0346933
RPS27A ribosomal protein S27a 0.0343575
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0340359
XPO1 exportin 1 0.033575
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0324942
EIF1 eukaryotic translation initiation factor 1 0.0321133
FDPS farnesyl diphosphate synthase 0.0318329
GDF15 growth differentiation factor 15 0.031438
ATF4 activating transcription factor 4 0.0291344
FTL ferritin, light polypeptide 0.0286769
VCL vinculin 0.0281129
RPL34 ribosomal protein L34 0.0265434
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0260284
RPS8 ribosomal protein S8 0.0259128
RPL11 ribosomal protein L11 0.0255902
LOC102724023 ES1 protein homolog, mitochondrial 0.0254163
RPL37A ribosomal protein L37a 0.0254083
RPLP2 ribosomal protein, large, P2 0.025374
RPS14 ribosomal protein S14 0.0249262
RPS12 ribosomal protein S12 0.0248747
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0245996
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0245193
INSIG1 insulin induced gene 1 0.0244507
RPL13A ribosomal protein L13a 0.0224783
RPL18 ribosomal protein L18 0.0216262
EPCAM epithelial cell adhesion molecule 0.0211973
RNF145 ring finger protein 145 0.0208655
RPL31 ribosomal protein L31 0.0206814
AREG amphiregulin 0.0205511
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0202149
RPS17 ribosomal protein S17 0.0197048
RPS27 ribosomal protein S27 0.0196942
KDM3A lysine (K)-specific demethylase 3A 0.018761
TPI1 triosephosphate isomerase 1 0.0186426
EIF4B eukaryotic translation initiation factor 4B 0.0185403
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0184618
NUPR1 nuclear protein, transcriptional regulator, 1 0.0184445
OGA O-GlcNAcase 0.0178977
B2M beta-2-microglobulin 0.0176985
BHLHE40 basic helix-loop-helix family, member e40 0.0176322
RPS26 ribosomal protein S26 0.0172707
RPS4X ribosomal protein S4, X-linked 0.0172638
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0172425
PCBP2 poly(rC) binding protein 2 0.0171599
NACA nascent polypeptide-associated complex alpha subunit 0.0171406
YBX1 Y box binding protein 1 0.0171339
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0170872
RPS7 ribosomal protein S7 0.0170772
OAZ1 ornithine decarboxylase antizyme 1 0.0167508
SREBF1 sterol regulatory element binding transcription factor 1 0.0166717
S100A14 S100 calcium binding protein A14 0.0166503
CLIC1 chloride intracellular channel 1 0.0165409
RPL5 ribosomal protein L5 0.0162914
EIF3E eukaryotic translation initiation factor 3, subunit E 0.015853
GADD45A growth arrest and DNA-damage-inducible, alpha 0.015599
SFTPA2 surfactant protein A2 0.0155758
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.0155275
RPL9 ribosomal protein L9 0.0154723
YTHDC1 YTH domain containing 1 0.0154326
TXNIP thioredoxin interacting protein 0.015235
WDR43 WD repeat domain 43 0.0152087
CIB1 calcium and integrin binding 1 (calmyrin) 0.0151949
RPL37 ribosomal protein L37 0.015043
SRRM2 serine/arginine repetitive matrix 2 0.0150291
ISG15 ISG15 ubiquitin-like modifier 0.0149853
MSMO1 methylsterol monooxygenase 1 0.0149825
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0149604
HSPA4L heat shock 70kDa protein 4-like 0.0148008
PGK1 phosphoglycerate kinase 1 0.0147845
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0144257
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0144117
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0142522
RSL1D1 ribosomal L1 domain containing 1 0.013532
RPS29 ribosomal protein S29 0.0133566
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.013275
EEF1G eukaryotic translation elongation factor 1 gamma 0.0131567
TFF3 trefoil factor 3 (intestinal) 0.0130963
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0130815
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0126768
RPL35 ribosomal protein L35 0.0126412
RPL10A ribosomal protein L10a 0.0123817
EREG epiregulin 0.012224
CLDN4 claudin 4 0.0122155

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.250478
FAT1 FAT atypical cadherin 1 -0.11812
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.109246
GMDS GDP-mannose 4,6-dehydratase -0.108694
CEMIP cell migration inducing protein, hyaluronan binding -0.0982732
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0928592
ITGA6 integrin, alpha 6 -0.0892447
LMO7 LIM domain 7 -0.0813775
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0809274
ASPH aspartate beta-hydroxylase -0.0795122
GREB1L growth regulation by estrogen in breast cancer-like -0.0754935
NALF1 NALCN channel auxiliary factor 1 -0.0695289
ANTXR2 anthrax toxin receptor 2 -0.0658959
NDRG1 N-myc downstream regulated 1 -0.0655323
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0635476
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0633004
NPSR1 neuropeptide S receptor 1 -0.062027
SMYD3 SET and MYND domain containing 3 -0.0617025
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0616826
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0557105
ESYT2 extended synaptotagmin-like protein 2 -0.0555326
PARD3 par-3 family cell polarity regulator -0.0524059
EZR ezrin -0.0517683
JMJD1C jumonji domain containing 1C -0.0509037
ATXN1 ataxin 1 -0.0501148
SAMD5 sterile alpha motif domain containing 5 -0.0496285
NEBL nebulette -0.0491893
MYO1E myosin IE -0.0485029
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0476934
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0473792
FLNB filamin B, beta -0.0471456
PSD3 pleckstrin and Sec7 domain containing 3 -0.0455577
LPP LIM domain containing preferred translocation partner in lipoma -0.0453168
PPARG peroxisome proliferator-activated receptor gamma -0.0451943
SBF2 SET binding factor 2 -0.0451147
ARHGAP26 Rho GTPase activating protein 26 -0.0441293
ACTN4 actinin, alpha 4 -0.0440905
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0435055
PTPRK protein tyrosine phosphatase, receptor type, K -0.0429805
MED13 mediator complex subunit 13 -0.0425501
CADPS Ca++-dependent secretion activator -0.0417073
KDM7A lysine (K)-specific demethylase 7A -0.041353
KMT2C lysine (K)-specific methyltransferase 2C -0.0413437
USP34 ubiquitin specific peptidase 34 -0.0411846
PATJ PATJ crumbs cell polarity complex component -0.0409185
PRSS3 protease, serine, 3 -0.0407401
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0403611
PTEN phosphatase and tensin homolog -0.0403529
CLTC clathrin, heavy chain (Hc) -0.0402179
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0400252
DSG2 desmoglein 2 -0.0392196
TTC3 tetratricopeptide repeat domain 3 -0.0390117
KDM4C lysine (K)-specific demethylase 4C -0.0388786
CCSER1 coiled-coil serine-rich protein 1 -0.0387626
NFIA nuclear factor I/A -0.0387609
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0385536
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0381414
EXT1 exostosin glycosyltransferase 1 -0.037774
POTEF POTE ankyrin domain family, member F -0.0375687
DLG1 discs, large homolog 1 (Drosophila) -0.0372833
GOLGB1 golgin B1 -0.0368397
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0365324
DIAPH2 diaphanous-related formin 2 -0.0360905
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0360896
TPM4 tropomyosin 4 -0.0357071
ACTG1 actin gamma 1 -0.035668
TBC1D5 TBC1 domain family, member 5 -0.0355881
ZNF292 zinc finger protein 292 -0.0355792
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355207
FNDC3B fibronectin type III domain containing 3B -0.0355062
ZBTB20 zinc finger and BTB domain containing 20 -0.0351058
AKAP9 A kinase (PRKA) anchor protein 9 -0.035072
SH3D19 SH3 domain containing 19 -0.0349836
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0349616
PKM pyruvate kinase, muscle -0.034773
PRELID2 PRELI domain containing 2 -0.0341345
PDE4D phosphodiesterase 4D, cAMP-specific -0.0340514
FHIT fragile histidine triad -0.0339616
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0339608
ZFAND3 zinc finger, AN1-type domain 3 -0.0338869
FOXO1 forkhead box O1 -0.0338526
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0337901
PDIA3 protein disulfide isomerase family A, member 3 -0.0337152
ALCAM activated leukocyte cell adhesion molecule -0.0335176
TRIO trio Rho guanine nucleotide exchange factor -0.0333551
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.033304
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0332244
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0331506
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.033135
MUC17 mucin 17, cell surface associated -0.0330819
BTBD9 BTB (POZ) domain containing 9 -0.0329325
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0328132
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0323953
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0323764
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0323045
PARD3B par-3 family cell polarity regulator beta -0.0322444
ARHGAP32 Rho GTPase activating protein 32 -0.031931
ANKRD17 ankyrin repeat domain 17 -0.0314415
FOXP1 forkhead box P1 -0.031317
SVIL supervillin -0.0312533