| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Osimertinib (mesylate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Osimertinib (mesylate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0712432 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0493319 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.035298 |
| PTMA | prothymosin, alpha | 0.0352741 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0318491 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0249878 |
| XPO1 | exportin 1 | 0.024367 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0238062 |
| PCBP2 | poly(rC) binding protein 2 | 0.0237999 |
| GOLGA4 | golgin A4 | 0.0231866 |
| MLEC | malectin | 0.0215739 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0210251 |
| RPS7 | ribosomal protein S7 | 0.0198535 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0183486 |
| RACK1 | receptor for activated C kinase 1 | 0.0182815 |
| YBX1 | Y box binding protein 1 | 0.0179117 |
| RPL3 | ribosomal protein L3 | 0.0177944 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0169471 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0168145 |
| ATF4 | activating transcription factor 4 | 0.0159626 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0152742 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0151986 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.0151363 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0150323 |
| NRN1 | neuritin 1 | 0.0143348 |
| ARRDC3 | arrestin domain containing 3 | 0.0140942 |
| BRD2 | bromodomain containing 2 | 0.0136661 |
| RPS3 | ribosomal protein S3 | 0.0127873 |
| HMGB2 | high mobility group box 2 | 0.012762 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.012561 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0123846 |
| KIF5B | kinesin family member 5B | 0.0120698 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0120602 |
| HDGF | hepatoma-derived growth factor | 0.0112435 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0102233 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0100743 |
| RPS3A | ribosomal protein S3A | 0.0100344 |
| TMF1 | TATA element modulatory factor 1 | 0.00988172 |
| ADM | adrenomedullin | 0.00981894 |
| S100A14 | S100 calcium binding protein A14 | 0.00977839 |
| RPL23 | ribosomal protein L23 | 0.0097664 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.00947989 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.00924452 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.00919807 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.00916857 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.00915198 |
| VEGFA | vascular endothelial growth factor A | 0.00890323 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.00876007 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.00869911 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.00863188 |
| UST | uronyl-2-sulfotransferase | 0.00862789 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.00823529 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.00817255 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.00807197 |
| PLBD1 | phospholipase B domain containing 1 | 0.00787623 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.00784319 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.00773409 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.00772185 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.00761899 |
| ANO10 | anoctamin 10 | 0.00760532 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 0.00758333 |
| JUN | jun proto-oncogene | 0.00755307 |
| TPI1 | triosephosphate isomerase 1 | 0.00754254 |
| ZNF622 | zinc finger protein 622 | 0.00738921 |
| RBM17 | RNA binding motif protein 17 | 0.00734727 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00732191 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.00725289 |
| GDF15 | growth differentiation factor 15 | 0.00722601 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0071917 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00719089 |
| TRIP10 | thyroid hormone receptor interactor 10 | 0.00718465 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00718439 |
| LRRC23 | leucine rich repeat containing 23 | 0.00706318 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00702566 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.00699596 |
| YTHDC1 | YTH domain containing 1 | 0.0069479 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.00693692 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0069368 |
| ZFP36 | ZFP36 ring finger protein | 0.00690675 |
| HOXA3 | homeobox A3 | 0.006805 |
| RPS2 | ribosomal protein S2 | 0.00672643 |
| GTF2F1 | general transcription factor IIF, polypeptide 1, 74kDa | 0.00666811 |
| FLNA | filamin A, alpha | 0.00662947 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.00658883 |
| CANX | calnexin | 0.0065614 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.00656076 |
| PHRF1 | PHD and ring finger domains 1 | 0.00650082 |
| MORF4L2 | mortality factor 4 like 2 | 0.00641149 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00631664 |
| OGA | O-GlcNAcase | 0.00628571 |
| IMPDH2 | IMP (inosine 5'-monophosphate) dehydrogenase 2 | 0.00627489 |
| AKAP17A | A kinase (PRKA) anchor protein 17A | 0.00614987 |
| RPS26 | ribosomal protein S26 | 0.00611311 |
| GOLGA2 | golgin A2 | 0.00606991 |
| PSMA5 | proteasome (prosome, macropain) subunit, alpha type, 5 | 0.00603665 |
| GATAD1 | GATA zinc finger domain containing 1 | 0.00602912 |
| RPL35A | ribosomal protein L35a | 0.00602636 |
| ASS1 | argininosuccinate synthase 1 | 0.00598325 |
| SAFB2 | scaffold attachment factor B2 | 0.00598199 |
| AFTPH | aftiphilin | 0.00592078 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.214025 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.158326 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.135701 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.131295 |
| LMO7 | LIM domain 7 | -0.131032 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.122886 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.109741 |
| MYO1E | myosin IE | -0.109547 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0970702 |
| FLNB | filamin B, beta | -0.0843131 |
| TXNRD1 | thioredoxin reductase 1 | -0.0800462 |
| RPS23 | ribosomal protein S23 | -0.0727062 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0701439 |
| PRSS3 | protease, serine, 3 | -0.0657446 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0608125 |
| FOXO1 | forkhead box O1 | -0.0606796 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0606175 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0594406 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0592364 |
| ITGA6 | integrin, alpha 6 | -0.0589187 |
| PKP2 | plakophilin 2 | -0.0544231 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0535726 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0533308 |
| RPLP1 | ribosomal protein, large, P1 | -0.0526632 |
| RPLP0 | ribosomal protein, large, P0 | -0.0522642 |
| ACTG1 | actin gamma 1 | -0.0521914 |
| FAT1 | FAT atypical cadherin 1 | -0.0520457 |
| WWC1 | WW and C2 domain containing 1 | -0.051333 |
| VCL | vinculin | -0.0510799 |
| PKM | pyruvate kinase, muscle | -0.0509737 |
| ANXA2 | annexin A2 | -0.0507445 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0502366 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0496842 |
| JMJD1C | jumonji domain containing 1C | -0.0495783 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.049471 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0486447 |
| HLA-B | major histocompatibility complex, class I, B | -0.0473249 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0468233 |
| FOXP1 | forkhead box P1 | -0.0462729 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0461269 |
| MUC13 | mucin 13, cell surface associated | -0.04573 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0450238 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.044842 |
| ASPH | aspartate beta-hydroxylase | -0.0438511 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0434948 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0434553 |
| RPS25 | ribosomal protein S25 | -0.0433016 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.042978 |
| SHROOM3 | shroom family member 3 | -0.0429335 |
| RPS29 | ribosomal protein S29 | -0.0420639 |
| TJP1 | tight junction protein 1 | -0.0419121 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0414592 |
| RPLP2 | ribosomal protein, large, P2 | -0.0414569 |
| RPS21 | ribosomal protein S21 | -0.0413007 |
| ACTN4 | actinin, alpha 4 | -0.0411228 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0410469 |
| MX1 | MX dynamin-like GTPase 1 | -0.0403237 |
| CUX1 | cut-like homeobox 1 | -0.0395926 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0394295 |
| TCF12 | transcription factor 12 | -0.0393435 |
| RIGI | RNA sensor RIG-I | -0.0391419 |
| RPS13 | ribosomal protein S13 | -0.0389899 |
| SMYD3 | SET and MYND domain containing 3 | -0.038905 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0388218 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0381027 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0378132 |
| RNF213 | ring finger protein 213 | -0.0375939 |
| EZR | ezrin | -0.0374231 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0372788 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0371616 |
| RPS24 | ribosomal protein S24 | -0.0370344 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0366267 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0364708 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0363523 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0360837 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.035962 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0353148 |
| DSG2 | desmoglein 2 | -0.0352733 |
| KRT8 | keratin 8, type II | -0.0350902 |
| ATXN1 | ataxin 1 | -0.0350791 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0348949 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0348323 |
| ABHD17C | abhydrolase domain containing 17C | -0.0345351 |
| FRMD5 | FERM domain containing 5 | -0.0345335 |
| TMEM45B | transmembrane protein 45B | -0.0336408 |
| DSG3 | desmoglein 3 | -0.0336059 |
| RPS11 | ribosomal protein S11 | -0.0334752 |
| MYO1D | myosin ID | -0.0333043 |
| RPS15 | ribosomal protein S15 | -0.0333012 |
| EGFR | epidermal growth factor receptor | -0.033056 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0329057 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0328967 |
| KRT18 | keratin 18, type I | -0.0328873 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0328354 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0327999 |
| SEPTIN10 | septin 10 | -0.032771 |
| COG5 | component of oligomeric golgi complex 5 | -0.0325769 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0325201 |
| RPS6 | ribosomal protein S6 | -0.0324951 |
| PARD3B | par-3 family cell polarity regulator beta | -0.032495 |
